Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"antibacterial targets"”.
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Suitability of RelBE and MazEF toxin-antitoxin systems as antibacterial targets
… revealed. The exploitation of TA systems as an antibacterial strategy via artificial activation of the toxin has been proposed and has considerable potential; however, efforts in this area remain in the early stages and several major questions remain. This thesis research investigated the …
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Investigation of the YefM-YoeBSa toxin-antitoxin systems as novel antibacterial targets
… the continued discovery and development of new antibacterial compounds. Bacterial toxin-antitoxin (TA) systems consist of a toxin capable of arresting cell growth and an antitoxin that binds to and inhibits the toxin under normal circumstances. Cellular stress causes a shift in the …
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Investigation of Narrow Spectrum Targets in Antibacterial Drug Discovery
… are associated with the use of broad-spectrum antibacterial agents, including collateral eradication of beneficial bacteria from the human microbiome, the onset of antibacterial-associated infections, and continued emergence of antibacterial drug resistance. As such, a critical need for novel …
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The evolution of AroA and MurA enzymes from Bacillus
MurA and AroA are important antibacterial targets due to their essentiality in microorganisms and the absence of their respective pathways within mammals. Although much research has focussed on these enzymes, little is known about the evolution of AroA and MurA. Ancestral sequence reconstruction …
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The glyoxylate shunt as a target for antibacterial intervention in Pseudomonas aeruginosa
… The glyoxylate shunt has potential as a new antibacterial target in P. aeruginosa as there is evidence to support that, besides carbon fixation, the glyoxylate shunt is implicated in virulence and is essential for establishing pulmonary infections. In this dissertation, the glyoxylate shunt …
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Assessment of potential antibacterial drug targets
The alarming increase in antibacterial drug resistance indicates an urgent need to develop new drugs. This project aimed to assess and select potential antibacterial targets and carry out initial biochemical characterisation concentrating on enzymes from biowarfare agents <i>Bacillus anthracis</i>, …