Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"antibacterial resistance"”.
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Molecular Mechanisms of Antibacterial Resistance Among Pseudomonas aeruginosa: Multi-Drug Efflux Pumps and Their Interactions with Other Resistance Mechanisms
… of multi-drug efflux pumps belonging to the Resistance-Nodulation- Division family of exporters has been shown to contribute to both intrinsic and acquired resistance among Pseudomonas aeruginosa. These pumps are able to recognize and export diverse compounds including several classes of …
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Structure-activity relationships of niclosamide to overcome colistin resistance
Antibacterial resistance poses a significant threat to global healthcare systems, particularly against Gram-negative bacteria (GNB). Addressing this challenge requires urgent development of new therapies, especially given the emergence of resistance even to last-resort antibiotics like colistin. …
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Chemical Synthesis of Novel Calcium-Dependent Lipopeptide Antibiotics
Antibacterial resistance represents one of the greatest challenges facing humanity. Infections caused by untreatable multi-drug resistant pathogens continue to rise resulting in as many as 700,000 deaths per year worldwide. Antimicrobial peptides (AMPs) have emerged as a rich yet underexplored …
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Mathematical Modeling and Disease Related Applications: A New Method of Estimating Bacterial Mutation Rates, Dynamics of Killer Yeast in a Chemostat, and Other Problems
… the devolopment of <i>Pseudomonas aeruginosa</i> antibacterial resistance in the Cystic Fibrosis patients. Current methods for determining mutation rate are quite involved mathematically or complicated experimentally. A new method for estimating mutation rate is discussed and compared with two …
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Mathematical Modeling and Disease Related Applications: A New Method of Estimating Bacterial Mutation Rates, Dynamics of Killer Yeast in a Chemostat, and Other Problems
… the devolopment of <i>Pseudomonas aeruginosa</i> antibacterial resistance in the Cystic Fibrosis patients. Current methods for determining mutation rate are quite involved mathematically or complicated experimentally. A new method for estimating mutation rate is discussed and compared with two …
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Investigation of the molecular basis of PAMP-induced resistance
… showed that these compounds are dispensable for antibacterial resistance triggered by the bacterial PAMP flagellin (flg22). In addition, as an unbiased approach, I performed a novel genetic screen aimed at identifying molecular components required for induced resistance to Pto DC3000. For this, I …
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Investigation of bioactive scaffolds as antimicrobials
… task. An additional approach to overcoming antibacterial resistance is the identification of antibiotic adjuvants. When co-administered with an antibiotic, such compounds can restore the biological activity of an antibiotic towards a resistant bacterial strain. In the Copp group, ongoing …
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Urinary tract infection in small children: aspects of bacteriology, vesicoureteral reflux and renal damage
… out of knowledge of the present antimicrobial resistance situation. Vesicoureteral reflux (VUR) is a well-known risk factor for UTI in children. Besides acute discomfort of UTI, long-term consequences associated with renal damage may occur. Research questions: What is the relation between UTI, …
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Investigation into the antimicrobial activity of cationic antibacterials.
… addressed by the 2011 WHOs World Health Day was antibacterial resistance. This action served to highlight the serious problem bacterial resistance now presents to healthcare professionals globally. This investigation focussed on the action of four cationic antimicrobial agents against E. coli, S. …
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Synthesis of FtsZ inhibitors : potential antibiotic agents
… (WHO) acknowledged the immediate threat of antibacterial resistance and the impact it will have on modern medicine. The greatest concern noted was that the development of novel antibacterial compounds was occurring at a slower rate than the development of resistance. One method identified to …
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Antibiotic-free PHA-based antibacterial materials for bone regeneration
The current world problem of antibacterial resistance to antibiotics has driven the need to develop new therapeutics as alternatives to antibiotic to prevent and fight infections. In the biomedical field, bone regeneration is one of the applications with the highest risk of infection. Therefore, …
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Metabolomics and chemical library screening for antibacterial drug discovery
… compound drug libraries to identify novel antibacterial activities against MRSA by increasing the dimensionality of the screening effort. One dimension involved generating and screening a human liver microsome metabolized drug library in parallel with the original library to identify …
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GLYCOMIMETIC LIGANDS TARGETING BACTERIAL LECTINS: RATIONAL DESIGN, SYNTHESIS AND BIOPHYSICAL EVALUATION
… increasingly difficult to treat due to rising antibacterial resistance. In this context, anti-adhesion therapy (AAT) is emerging as a complementary approach to traditional antibiotics. AAT aims to inhibit the adhesion of pathogens to host cells, which is one of the initial and essential steps …
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Interaction of fluroquinolone antibiotics with nanophase metal oxide photocatalysts and soil minerals
… This study focuses on a select group of antibacterial agents, fluoroquinolones (FQ). They are important from the therapeutic standpoint as they are often our last line of defense against highly resilient bacterial infections. Dissemination of fluoroquinolones in the environment has raised …
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Innovation in antimicrobial resistance: development of new antimicrobials and coadjutants to successfully treat bacterial infections [Innovazione nella resistenza antimicrobica: sviluppo di nuovi antimicrobici e coadiuvanti per trattare in modo efficace le infezioni batteriche]
L’aumento della resistenza dei patogeni batterici agli agenti antimicrobici costituisce una grave minaccia per la salute pubblica, determinando un incremento dei tassi di malattia e morte. I ceppi di batteri Gram-positivi e Gram-negativi resistenti ai farmaci stanno diventando sempre più difficili …