Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"antiandrogen"”.
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Effects of the Antiandrogen Cyproterone Acetate on Maturing Male Mice.
Antiandrogens are defined as substances capable of selectively suppressing the biological activity of androgens at their target sites (Dorfman, 1970). In the last two decades, extensive use has been made of antiandrogens, both clinically and as a research tool. They have been used for hirsutism and …
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Various aspects of reproductive control in freshwater fishes
… testosterone, cyproterone acetate (CA) (an antiandrogen) or a combination of the two steroids to determine effects on behavior, coloration, and gametogenesis. The antiandrogen did not fully block the effects of endogenous or exogenous testosterone in enhancing male sexual behavior and …
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Targeting DNA Repair in Prostate Cancer: Therapeutic Combinations & Disease Models
… defects, when combined with standard-of-care antiandrogen therapies. However, the dominant molecular mechanisms underlying tumour cell responses to DNA repair and antiandrogen combination treatment remain unascertained. Within this thesis, I review the rationale supporting the clinical utility …
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Antiandrogens and Development of the Male Rat Reproductive Tract
Di(n-butyl) phthalate (DBP) is an antiandrogen with known human exposure. The objectives of this thesis were to investigate the development of male reproductive tract malformations secondary to in utero DBP exposure from the fetus to the adult, to characterize the effects of DBP on fetal testicular …
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Role of 11-ketotestosterone, testosterone, and prolactin in the expression of reproductive behaviors by male bluegill
… the effect of exogenously added 11KT, T, or an antiandrogen--cyproterone acetate (CYA) on such behaviors was investigated through observations and underwater tests of treated male bluegill. Finally, the third study investigated the involvement of prolactin (PRL), a protein hormone associated …
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Androgen receptor signaling mechanisms in bone
… trabecular but not cortical bone mass. Since antiandrogens are frequently used in the treatment of men with prostate cancer, we investigated the possible skeletal side effects of the recently approved antiandrogen drug enzalutamide (Paper II). Although this drug effectively reduced the weights …
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Investigation of the role of Col4a1 and Itga11 in enzalutamide resistance of prostate cancer cells
… and Itga11 in the development of resistance to antiandrogen Enzalutamide in murine prostate cancer bone metastasis cell line Myc-CaP Bo 6943, which is susceptible to treatment. It also aimed to determine the potential effect of tumour cell-derived matrix (CDM) on macrophage polarization. Myc-Cap …
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Nanotherapies for Treating Prostate Cancer
… prostate cancer. The effect of bicalutamide (antiandrogen) and embelin (XIAP inhibitor) on the growth of prostate cancer cells in vitro and in vivo was first examined. Embelin induced caspase 3 and 9 activation in LNCaP and C4-2 cells by decreasing XIAP expression and was more potent than …
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Second-site inhibitors of the estrogen and androgen hormone receptors
… has an activity profile similar to MDV3100, an antiandrogen currently in phase III clinical trials, and demonstrates no toxicity at any of the assayed concentrations. Based on this initial success, a focused library containing cyclobutanes with one or two-atom substituents on the pyrimidine …