Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"anti-virulence"”.
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Studies Toward the Syntheses of Antiarrythmic, Anti-Virulence, and Anticancer Small Molecules
… of three projects: a) the development of antiarrythmic analogs of 17(R),18(S)-epoxyeicosatetraenoic acid for the treatment of atrial fibrillation, b) the development of potent inhibitors of QseC mediated virulence gene expression, and c) studies toward a biomimetic total synthesis of …
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Anti-candida and Anti-virulence Activity of Essential Oils and Their Components
… and so there is an urgent need to discover novel antifungals. Rather than killing the fungal cells, which requires quite high specificity and can lead to the emergence of further resistance, inhibiting growth and virulence factors in fungal cells represents a good alternative for the development …
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Characterization of the grvA and grvB Anti -Virulence Genes Encoded by the Gifsy-2 and Gifsy -1 Bacteriophages of Salmonella Typhimurium
… contribute significantly to S. typhimurium virulence. We have been studying biology of these phage to determine the effects of Gifsy-1 and Gifsy-2 on the virulence of S. typhimurium. The Gifsy-2 phage carries the periplasmic superoxide dismutase gene, sodCI. Using the IVET system, we …
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Molecular Engineering Approaches against Germs, Spores and Biofilm Formation
… the possible new routes and targets for future anti-virulence small molecules against biofilm formation. This dissertation is thus divided into these three sections accordingly: Traditional zwitterionic polymers have been widely accepted and routinely applied because of their biocompatibility …
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Head-to-head terpene synthases: Mechanism of action and inhibition
… a carotenoid pigment, and a major virulence factor in S. aureus. Inhibitors targeting CrtM and staphyloxanthin biosynthesis are therefore of interest as “anti-virulence” based therapy for treating S. aureus infection. I studied the structure-activity-relationship of …
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Quorum Sensing and Virulence Regulation in Commensal and Pathogenic Bacteria
… including genetic competence, biofilm formation, virulence, and horizontal gene transfer. In streptococci, QS commonly occurs through the ComABCDE and ComRS signaling pathways, which coordinate transcriptional responses through competence-associated regulators such as ComX. Although canonical …
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Analysis of the streptococcal cpsa protein in dna-binding and regulation of capsule and cell wall maintenance
… pathogen GBS, and how this regulation affects virulence in in-vitro, ex-vivo, and in-vivo models of pathogenesis. We have determined that the membrane topology of the CpsA protein consists of a small cytoplasmic N-terminus, and a large extracellular C-terminus that contains the conserved …
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Structural and Functional Characterization of SPOA Domains in Salmonella Typhimurium Type III Secretion Systems
… optimistically believed to be a relic of the pre-antibiotic era, bacterial pathogens remain a substantial threat to human health, and the growing epidemic of antibiotic resistance has raised concerns for the long term prospects of antimicrobial therapy. By understanding the mechanisms used by …
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Understanding protease-mediated host-pathogen interactions in <i style="">Proteus mirabilis</i>
… all nosocomial infections. ZapA is an important virulence factor that contributes to the evasion of <i>P. mirabilis</i> from innate immunity via the hydrolysis of host structural proteins such as cytoskeletal and extracellular matrix components, and immunoproteins such as immunoglobulins, …
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Post-translational modification of proteins secreted by Pseudomonas aeruginosa and its role in bacterial physiology
… is the secretion of an extensive arsenal of virulence factors. These virulence factors cause considerable tissue damage and are also involved in attenuation of the host immune response, as well as inter-kingdom defences. Maintaining control over the production, secretion and activity of these …
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Analysis of Small Molecule Inhibitors Aimed at Bacterial Virulence
<p>The emergence of antibiotic-resistant bacterial pathogens and the discovery of new bacterial pathogens have motivated the development of novel antibacterials. One recently proposed strategy is to target pathogenic bacteria specifically by inhibiting virulence mechanisms as opposed to killing …
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Investigating novel treatment approaches to combat Clostridioides difficile
… Clostridioides difficile is the leading cause of antibiotic-induced diarrhea and colitis in hospitals and communities worldwide. The enteric pathogen, classified to be an "urgent threat" by the United States Center for Disease Control and Prevention (CDC), capitalizes on disrupted intestinal …
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Interaction of skin cells with skin microbiota
… NCTC 11047 supernatant on the biofilm formation, virulence factors production, and quorum sensing network of P. aeruginosa strains NCTC 10662 and PAO1 was investigated using a range of colorimetric assays and RT-qPCR. Also, the effect of S. epidermidis supernatant on the viability, migration, and …
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Rational Development of Small Molecules Targeting Virulence of Pseudomonas aeruginosa
… as a critical priority pathogen in need of new antibiotics by the World Health Organisation. Its large genome allows it to adapt to a vast range of ecological niches meaning it is found almost ubiquitously in the environment, but as an opportunistic pathogen it poses almost no threat unless an …
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The Type IV Pilus Assembly ATPase PilB as a Regulator of Biofilm Formation and an Antivirulence Target
… in motility and biofilm formation, T4P are key virulence factors in many significant human pathogens. Antivirulence chemotherapeutics are considered to be a promising alternative to antibiotics, as they target disease processes rather than bacterial viability. Because PilB is essential for T4P …
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Rational development of novel small molecule leads against the transcriptional activator protein ExsA of Pseudomonas aeruginosa
… drugs. Besides acquiring resistance mutations to antibiotic targets, the pathogen also possesses a suite of efflux pumps capable of exporting a wide range of antibiotics. P. aeruginosa has two distinct virulent lifestyles which correspond to acute and chronic infections. P. aeruginosa’s type three …
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Sortases: Keystones to Virulence and Targets for Anti-Infective Therapy
… many existing therapies. Thus, novel targets for antimicrobial development are urgently needed. An attractive candidate for a new class of anti-virulence chemotherapeutics is the sortase class of enzymes. Sortases are extracellular transpeptidases unique to Gram-positive bacteria. Their function …
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Investigation of Biofilm Development by Antibiotic Resistant Urinary Tract Infection Pathogens and Evaluation of the Antimicrobial Activity of Natural Products on Carbapenem-Resistant Escherichia coli IMP and Klebsiella pneumoniae NDM-1.
… Moreover, understanding the efficacy of known antimicrobials against drug-resistant bacteria associated with such common infections as UTIs may result in the discovery of existing therapeutics that are able to impact, at least partially, the bacterial biofilm. Aims The aim of the study is to …