Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"anti-viral therapy"”.
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Inhibiting HIV-1 entry : utilizing a transient intermediate of viral membrane fusion as a target for drug discovery
… The first step of this process is the fusion of viral and cellular membranes, which allows the release of the viral contents into the cell. An envelope glycoprotein on the surface of the virus is responsible for fusion. It is usually composed of two subunits, a surface subunit that attaches the …
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T-lymphocyte senescence and hepatitis C virus infection
… length predicted a failure to respond to anti-viral treatment for HCV infection. Unexpectedly, subjects with non-viraemic HCV had short CD8+ telomere length. Liver biopsy tissue from a cohort of subjects with non-viraemic HCV was studied and demonstrated significant inflammation or …
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Characterizing the epidemiology of ranavirus in North American chelonians: diagnosis, surveillance, pathogenesis, and treatment
… less well understood. In this dissertation, a quantitative PCR was developed that was 100% efficient in detecting the 54 bp segment of the major capsid protein of frog virus 3 (FV3) (Genus: Ranavirus; Family: Iridoviridae). This assay was used to estimate the prevalence of ranavirus infections in …
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Peripheral Generation of Regulatory T Cells in Health and Disease
… patients and their depletion in-vitro increases anti HCV responses when measured by a sensitive CFSE-based flow cytometric proliferation assay. The CFSE-based assay, developed and validated by my laboratory, has a greater ability to detect low frequency and low avidity type T cell responses in …
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Regulation of The Escrt Function of Alix
… body) sorting, cytokinetic abscission and retroviral budding. Previous studies have demonstrated that ALIX involvement in these ESCRT-mediated processes requires ALIX interaction with the ESCRT-III component CHMP4 as well as a cargo protein. However, the native form of ALIX contains a default …
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Understanding and Targeting Clearance of Persistent HPV Infections
… regression. Persistent infected cells form a viral reservoir, causing disease occurrence and are particularly problematic during carcinogenesis development for high-risk types; therefore, understanding HPV-mediated epithelial homeostasis is essential for understanding disease progression. In …
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ENDOGENOUS ANTIVIRAL PROPERTIES OF RED BLOOD CELL-DERIVED EXTRACELLULAR VESICLES AND THEIR AUGMENTATION OF ANTIVIRAL OLIGONUCLEOTIDE THERAPY
… the urgent need for effective and accessible antiviral therapies. We explored the intrinsic antiviral activity of red blood cell-derived extracellular vesicles (RBCEVs) against SARS-CoV-2 and their use as delivery vehicles for antisense oligonucleotides (ASOs). RBCEVs inhibited both …