Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"anti-tumor agents"”.
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Synthesis of Novel Sulfonamide-Based Calpain Inhibitors and Their Potential as Anti-Tumor Agents
… are therefore of interest as therapeutic agents and as biomedical tools.</p> <p>Several potent calpain inhibitors isolated from natural sources as well as synthesized in the laboratory have been reported (Chapter 1.4). Unfortunately, most of the inhibitors show poor calpain selectivity, …
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Selective Elimination of Malignant Melanoma Using The Novel Anti-Tumor Agents, Osw-1 and Peitc
… Herein, we investigated the mechanims of anticancer activity and therapeutic selectivity of two novel agents, 3β, 16β, 17α-trihydroxycholest-5-en-22-one 16-<em>O</em>-[2-<em>O</em>-4-methoxybenzoyl-β-D-xylopyranosyl]- [1→3]-2-<em>O</em>-acetyl-α-l-arabinopyranoside (OSW-1) and …
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IMPROVED SYNTHESIS OF 3-ARYL-ISOXAZOLES AS INTERMEDIATES FOR NOVEL G-QUADRUPLEX BINDING ANTI-TUMOR AGENTS
… scientific community. Current chemotherapeutic agents exhibit broad toxicity to patients; G4 has the potential to be selectively targeted by novel chemotherapeutic agents that exhibit toxicity specific towards cancer cells. Anthracenyl isoxazolyl amides (AIMs) have shown potent anti-tumor …
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IMPROVED SYNTHESIS OF 3-ARYL-ISOXAZOLES AS INTERMEDIATES FOR NOVEL G-QUADRUPLEX BINDING ANTI-TUMOR AGENTS
… scientific community. Current chemotherapeutic agents exhibit broad toxicity to patients; G4 has the potential to be selectively targeted by novel chemotherapeutic agents that exhibit toxicity specific towards cancer cells. Anthracenyl isoxazolyl amides (AIMs) have shown potent anti-tumor …
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Synthesis of novel 5-substituted pyrrolo[2,3-d]pyrimidine antifolates as selective and potent anti-tumor agents
… several compounds are successfully being used as anticancer agents. Methotrexate (MTX), pemetrexed (PMX), raltitrexed (RTX): are a few examples of classical antifolates that are currently in clinical use. Although these compounds are widely used, all of them show dose limiting toxicity due to …
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The Synthesis, Characterization, Spectroscopic and Biological Activity Studies of Pt(Ii) and Pd(Ii) Cyanoximates
… and palladium (Pd) compounds are established anticancer inorganice pharmaceuticals. Substantial biological activity (growth regulation, antimicrobial, pesticide detoxifying) was also found during the last two decases of investigations of cyanoximes. An attempt has been made to combine useful …
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In vitro permeability studies of antitumor compounds, thioxanthones across two model barriers, and their availability in vivo
<p>One of the reasons for poor response of tumors is their three dimensional structure (micro-environment), which forms a penetration barrier to anti-tumor agents. A drug has to cross the interstitial space of tumors and many layers of cells to reach the interior of a tumor. The main objective of …
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Proposed Route to Cyclopenta[c]thiophenes via Activated Methylene
… are potential organic semiconductors and anti-tumor agents. The research presented shows the successful and novel conversion of 3,4-bis(chloromethyl)-2,5-dimethylthiophene and 3,4-bis(bromomethyl)-2,5-dimethylthiophene to a fused 5,5'-fused membered ring which is the precursor to …
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The Substituted Pyrrole JB-03-14 Induces Autophagic Cell Death and Growth Arrest in Breast Tumor Cells
… the demand for better chemotherapeutic agents that are more potent at destroying tumor cell populations and more selective for the specific tumor versus normal host tissues. This project is directed at discovering new anti-tumor agents that are effective against breast cancer based on …
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Enantioselective total syntheses of acylfulvene, irofulven, and the agelastatins
I. Enantioselective Total Synthesis of (-)-Acylfulvene, and (-)-Irofulven We report the enantioselective total synthesis of (-)-acylfulvene and (-)-irofulven, which features metathesis reactions for the rapid assembly of the molecular framework of these anti tumor agents. We discuss (1) the …
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Crystallographic studies on enzymatic halogenation of natural products
… common and serve roles as hormones, pesticides, antibiotics, and anti-tumor agents. The incorporation of a halogen atom into an organic scaffold can tune the molecule's potency and selectivity, making halogenation an important tailoring reaction. To understand the mechanisms of enzymatic …
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Induction And Regulation Of Autophagy By Novel Prenylation Inhibitors In Sts-26t Malignant Peripheral Nerve Sheath Tumor (mpnst) Cells
… there is still an urgent need of effective agents of this class of anti-tumor therapeutics. In this dissertation, I sought to delve into this issue by characterizing our novel prenylation inhibitors and their potential as anti-tumor agents. Novel compounds, GGTI-2Z and FTI-1, were used in …
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Improved delivery of molecularly targeted agents upon modulation of multidrug resistance efflux proteins at mouse blood brain barrier
Recurrent brain tumors are one of the most lethal forms of solid tumors with poor prognosis. Molecularly targeted therapy, inhibiting the tyrosine kinase domain of epidermal growth factor receptor (EGFR), platelet derived growth factor receptor (PDGFR) and vascular endothelial growth factor …
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Mechanistic investigation of anticancer agents that damage DNA and interact with the estrogen receptor
… goals of cancer chemotherapy is the design of antitumor agents that achieve selective targeting of tumor cells while minimizing toxicity to normal tissues. We have synthesized a series of DNA damaging agents that are designed to disrupt selectively the DNA repair and signaling pathways in tumor …
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Roles of Cytoplasmic Deacetylase Hdac6 in Oncogenic Tumorigenesis
… cells and therefore appear to be promising anti-tumor agents. While transcriptional deregulation is thought to be the main mechanism underlying their therapeutic effects, the exact mechanisms and targets by which HDAC inhibitors, which are mostly non-specific, achieve their anti-tumor …
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Photochemistry and Photophysics of Octahedral Ruthenium Complexes
… in the absence of light, indicating potential as anti-tumor agents for use in photodynamic therapy (PDT). cis-[Ru(tpy)(AN)<sub>2</sub>Cl]<sup>+</sup> has a higher quantum yield of ligand substitution and a lower energy metal to ligand charge transfer (MLCT) transition showing binding to DNA when …
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Investigating Novel Inhibitors of Epithelial - Mesenchymal Transition (EMT) and Cancer Stem Cells (CSCs) in Pancreatic Cancer
… Various efforts have been made to develop anti-tumor agents through modulation of important signaling pathways involved in EMT and CSCs. However, there has not been a clinical success in a specific inhibitor to CSCs, or the EMT process. Extracts from medicinal plants have been rich sources …