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Showing 1 to 12 of 12 for “"anti-sigma"”.
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Regulated intramembrane proteolysis in the control of the Bacillus subtilis anti-sigma factor RsiW.
… activity of the extracytoplasmic function (ECF)-sigma factor SigW of the Gram-positive soil bacterium Bacillus subtilis is modulated by a specific membrane-bound anti-sigma factor (RsiW). Initiated most likely by cell wall stress, RsiW is degraded by the mechanism of regulated intramembrane …
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Structural Analysis of an RNA Polymerase Sigma Factor and Its Anti-sigma: sigma28/FLGM
<p>Eubacterial sigma (σ) factors are required during the initiation of transcription, where they play key roles in promoter recognition, melting, and transcriptional regulation, sigma is a dissociable subunit of RNA polymerase (RNAP), and sequence-specifically recognizes promoters, but only after …
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Étude in vitro de la régulation post-traductionnelle du facteur sigma F de mycobacterium tuberculosis
… en 1998, contiendrait les gènes de 13 facteurs [sigma], de même que de plusieurs facteurs anti-, et anti-anti-[sigma] présumés. Au cours des travaux présentés dans cette thèse, nous nous sommes donc intéressés particulièrement au facteur [sigma[indice supérieurF]] et à sa régulation …
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THE ROLE OF THE PARTNER SWITCHING MECHANISM IN REGULATION OF THE CHLAMYDIAL DEVELOPMENTAL CYCLE
… into phenotypic changes via regulation of sigma28. The putative chlamydial PSM is composed of two sensor phosphatases (SPs: RsbU and CTL0852), two anti-anti-sigma factors (AASFs: RsbV1 and RsbV2), an anti-sigma factor (ASF: RsbW), and sigma28. Using the Bacterial Adenylate Cyclase Two …
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A study of the C-terminus in prestin by designing cleavable constructs
… as the STAS domain (Sulfate Transporters and Anti-Sigma factor antagonist), whose function re- mains unknown. In this work, we engineered prestin by inserting three types of short peptides, flexible, rigid and cleavable linkers, into different positions in the C- terminus and tested prestin’s …
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Allosteric activation of periplasmic HtrA proteases
… protease, cleaves RseA, a transmembrane anti-sigma factor, causing downstream release of the [sgima]E sigma factor and transcription of stress-response genes. Each subunit of the DegS trimer contains a trypsin-like protease domain and a PDZ domain. In the absence of stress, autoinhibitory …
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Alternative regulation of the alginate algD operon by an activated AlgB in nonmucoid Pseudomonas aeruginosa is dependent on Sigma 54
… major regulators in association with the ECF sigma factor, σ22, in mucoid strains that are typically defective in anti-sigma factor, MucA. One such algD regulator is AlgB, a member of the NtrC family of two-component systems, which typically utilize σ54. However, neither σ54 nor the cognate …
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Development Of Peptide Inhibitors Targeting Clostridium Difficile Toxins A/b And Characterizing The Regulatory Role Of A Putative Negative Regulator Tcdc In Clostridium Difficile Toxin Gene Expression
… <p>diseases often associated with broad-spectrum antibiotic usage. TcdA and TcdB</p> <p>are the key virulence factors involved in major patho-physiology. While standard</p> <p>antibiotics provide some respite, due to the high relapse rates and the emergence of more</p> <p>severe disease …
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A model for sigma factor competition in bacterial cells
… several stress-specific molecules such as sigma factors. They reversibly bind the RNA polymerase to form the so-called holoenzyme and direct it towards the appropriate stress response genes. In exponentially growing E. coli cells, the majority of the transcriptional activity is carried out …
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IN VITRO AND IN VIVO ACTIVITY OF DINB: ROLE IN MUCOID CONVERSION OF PSEUDOMONAS AERUGINOSA
… protects against reactive oxygen species, antibiotics and host immune cells. The majority of the mucoid variants that emerge from CF patients have mutations in mucA, which encodes an anti-sigma factor and this mutation allows for the biosynthesis of alginate. The mechanisms leading to the …
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Structural Characterization of the C-terminus of the Cochlear Motor Protein Prestin: Intrinsic Disorder Linked to Voltage Sensor Function
… loop partitions the sulfate transporter and anti-sigma factor (STAS) domain in the C-terminus. To investigate the structural and functional role of the ‘loop’ (residues 571-635), the sequence was deleted (Δ) from prestin cDNA and transfected into HEK 293T cells. Whole-cell voltage clamp …
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Untersuchungen zur Regulation Motilitäts-assoziierter Gene in Helicobacter pylori
… deren Transkription von den beiden alternativen Sigma-Faktoren Sigma28 und Sigma54 kontrolliert wird. Um die transkriptionelle Regulation der beiden Gene in zwei unterschiedlichen Flagellenregulons zu untersuchen, wurde die Genexpression von flaA und flaB abhängig von der Wachstumsphase …