Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"anti-proliferative activity"”.
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Host-defence peptides from frog skin secretions: identification and bioactivity evaluation and optimisation
With the rapid development of antibiotic resistance, new types of antimicrobial drugs are urgently needed. A novel AMP, Brevinin-1H, was isolated from skin secretion of Amolops hainanensis (A. hainanensis) with broad spectrum antimicrobial activity, anti-proliferative activity, and strong …
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Anti-proliferative effect of methyl gallate isolated from mangifera pajang kosterman in selected cancer cell lines
… extract of the M. pajang and determine the anti-proliferative potential of aromatic ester, methyl gallate which induce the cell cycle arrest and killing mechanism via apoptosis in selected cancer cell line. Chromatography methods were used in this study to isolate methyl gallate (C8H8O5) …
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A bioactivity peptide QUB2852 from the frog skin secretion of pelophylax nigromaculata
Due to the resistance of antibiotics, antimicrobial peptides (AMPs) become research hotspot. Majority of AMPs can disrupt the cell membrane of microorganisms, leading to the death of microorganisms. In this study, the AMP QUB-2852 was identified from the skin secretion of pelophylax nigromaculata …
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Drug repurposing against the store-operated calcium entry (SOCE) pathway and subsequent exploration of SOCE in oligodendrocyte progenitor cells
… of those lung cancer cells. Interestingly, the anti-proliferative activity of most of the selected drugs were observed at concentrations at which they could significantly inhibit SOCE identified in those lung cancer cells. Although the possible contribution of the inhibition of the known targets …
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Characterization of Mycochemicals and Bioactivities of a New Zealand Native Mushroom Hericium novae-zealandiae
… method was subsequently applied for the quantification of the identified compounds. In addition, the bioactivities of the extracts and the compounds were evaluated in relation to anti-proliferation of three prostate cancer (PCa) cell lines (DU145, LNCaP, and PC3), AChE inhibition and …
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Functional and structural uncoupling of the angiogenic and enzymatic inhibitory activity of TIMPs : loop 6 of TIMP-2 is a novel inhibitor of angiogenesis
… to inhibit matrix metalloproteinase (MMP) activity. To address these differences, structure-function studies were conducted to identify and characterize the anti-angiogenic domains of TIMP-2, the endogenous MMP inhibitor that uniquely inhibits capillary endothelial cell (EC) proliferation …
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Investigation of anthracycline based topoisomerase II inhibitors in triple negative breast cancer
… to free MTX. KP71 exhibited significant anti-proliferative activity in BCa cell lines (MDA-MB-231, MDA-MB-468, and MCF7) using the 3-[4, 5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide and resazurin assay. The results of KP71 demonstrated DNA damage through Western blotting, …
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Optimisation of the anti-cancer efficacy of various tocotrienol isomers by entrapment in tumour-targeted vesicles
… as part of vitamin E. Although known for its anti-cancer activity, its therapeutic use is hampered by its limited ability to specifically reach tumours after intravenous administration. Recently, we demonstrated that tocotrienol-rich fraction entrapped in transferrin-bearing vesicles led to an …
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Identification and evaluation of bioactive peptides from amphibian skin and rational design of new analogues
Human demand for novel antimicrobials has increased due to the rapid development of antibiotic-resistant bacteria. Because of their remarkable antimicrobial capacity, antimicrobial peptides are at the forefront of new antibacterial drugs. In our research, we are working with the isolation and …
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Chemical, Biological, and Preliminary In Vitro Studies of Novel Vanadium(IV) Complexes with Schiff Bases and Thiosemicarbazone Ligands
… were observed to exhibit anti-proliferative activity against three colon cancer cell lines, HTC-116, Caco-2, and HT-29. When the anti-proliferative effects were compared with that of non-cancerous colonic myofibroblasts, less inhibition was observed. The results obtained …
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Development of Non-Atp Competitive, Plk1-Selective Inhibitors
… discovery strategy called REPLACE uses structure activity relationships of peptide inhibitors to generate a pharmaceutically acceptable lead molecule by replacing individual amino acid residues with non-peptide fragments. REPLACE was used to identify fragment mimetics for determinants from the …
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Interactions between skimmed bovine milk and tea infusions under an acidulous environment: a thesis submitted in partial fulfilment of the requirements for the Degree of Doctor of Philosophy at Lincoln University
… were measured by texture analyser, and the antioxidant capacity of the gels was determined through four assays - Total phenolic content (TPC) by Folin-Ciocalteu assay, free radical scavenging ability by DPPH assay along with ABTS assay and FRAP assay. The cellular antioxidant activity and …
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Effects of modified bioactive pectins on colon cancer cells in vitro
… with pH, heat or enzymes, has been shown to have anti-cancer activity in several cancer cell lines. The galactan chains of MP are postulated to be essential for bioactivity due to their ability to bind and inhibit the pro-metastatic protein galectin-3 (Gal3) on cancer cells. However, the …
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Functional genomic study of the parotoid secretion from Bufo gargarizans
… proteins, which were reported to have large quantities in parotoid secretion have not been widely studied. <br/>Here, we focused on the proteins and peptides derived from the parotoid secretion of Bufo gargarizans. A comprehensive technology, RNA-Seq, was performed to obtain the whole …
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Evaluation of Glycogen Synthase Kinase 3 as a drug target in African trypanosomes
… TbGSK3 short. In particular two series showed anti-proliferative activity against the parasite. GSK3 07 series was further investigated by the Drug Discovery Unit with a phenotypic approach for its off-target effects, and GSK3 09 series was further validated to act “on target”. The latter …
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URSOLIC ACID INHIBITED PROLIFERATION AND INVASION OF MDA-MB-231 HUMAN BREAST CANCER CELLS VIA REGULATING CELLULAR SIGNAL TRANSDUCTION PATHWAYS
… herbs, and spices, has been reported to have anti-cancer activities. However, its mechanism of actions against breast cancer remain unclear. The hypothesis of this study is that UA inhibits proliferation and invasion of MDA-MB-231 human breast cancer cells via regulating cellular signal …
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Approaches Towards the Inhibition of Anti-Apoptotic Proteins
Anti-apoptotic proteins play a fundamental role in cell survival. Under physiological conditions, such proteins trigger apoptosis in defective or damaged cells only; under pathological conditions, however, they can be dysregulated allowing the cells to survive despite being harmful. Considering the …
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Identification and rational design of Bowman-Birk type protease inhibitory peptides derived from Ranidae frogs
… by Ile in P2’ enhanced the trypsin inhibitory activity of QUB1801 more than parent QUB1875 and both could inhibit the up-regulation of pro-inflammatory cytokines induced by lipopolysaccharide (LPS) in THP-1 (TNF-α, IL-6 and IL-1β) and RAW264.7 cells (TNF-α and IL-6). At the same time, a …
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Development of Novel anti-estrogens for endocrine resistant Breast Cancer
… of estrogen receptor. ER mediates strong anti-inflammatory signaling in ER+ tissues. Once activated with estradiol (E2), ER inhibits inflammatory gene expression via protein-protein interactions that block NF-kappa B transcriptional activity. Importantly, NF-kappa B is a primary mediator …
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Anti-breast cancer activity of Coptidis Rhizoma-Euodiae Fructus formulae
… both herbs have been widely reported including anti-cancer activity. Dual herbal formulae combined with Coptis and Euodia with different ratio have been clinically used to treat multiple digestive system disorders. The aims of this research are to evaluate the anti-breast cancer potential of …
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