Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 149 for “"anti-proliferative"”.
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Anti-proliferative effect of methyl gallate isolated from mangifera pajang kosterman in selected cancer cell lines
… extract of the M. pajang and determine the anti-proliferative potential of aromatic ester, methyl gallate which induce the cell cycle arrest and killing mechanism via apoptosis in selected cancer cell line. Chromatography methods were used in this study to isolate methyl gallate (C8H8O5) …
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Investigation of the Anti-Proliferative and Pro-Apoptotic Effects of Rosemary (Rosmarinus officinalis) Extract on Androgen Independent Prostate Cancer Cells
… constituents have been shown to have anticancer properties, but the exact effects and mechanisms of action are not known. The purpose of the present study was to investigate the potential pro-apoptotic and anti-proliferative effects of rosemary (Rosmarinus officinalis) extract (RE) on …
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Investigation on donkey milk protein fractions: in vitro antimicrobial, antiviral and anti-proliferative activities and casein separation by cation exchange chromatography
… asina, con particolare riguardo alle proprietà antimicrobiche, antivirali e anti-proliferative delle sue frazioni proteiche. Nel primo Capitolo si introduce il latte di asina e se ne descrivono la composizione ed i relativi aspetti igienico-sanitari. Inoltre, il suo utilizzo nell’alimentazione …
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The Role and Mechanism of The Homeobox Gene Dlx4 In Transforming Growth Factor-B Resistance In Cancer
… homeostasis. In normal cells, TGF-b exerts an anti-proliferative effect. TGF-b inhibits cell growth by controlling a cytostatic program that includes activation of the cyclin-dependent kinase inhibitors p15<sup>Ink4B</sup> and p21<sup>WAF1/Cip1</sup> and repression of c-myc. In contrast to …
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Investigation of the Effects of Genistein and Fenretinide on Ovarian Cancer Cells
… Unlike low doses of fenretinide, genistein had anti-proliferative effects on both cell lines. There were no additive or synergistic effects of the two compounds. Higher dose treatments induced anti-proliferative effects and apoptotic cell death in both A2780s and A2780cp cells, with a greater …
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Characterization of Mycochemicals and Bioactivities of a New Zealand Native Mushroom Hericium novae-zealandiae
… method was subsequently applied for the quantification of the identified compounds. In addition, the bioactivities of the extracts and the compounds were evaluated in relation to anti-proliferation of three prostate cancer (PCa) cell lines (DU145, LNCaP, and PC3), AChE inhibition and …
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Optimisation of the anti-cancer efficacy of various tocotrienol isomers by entrapment in tumour-targeted vesicles
… as part of vitamin E. Although known for its anti-cancer activity, its therapeutic use is hampered by its limited ability to specifically reach tumours after intravenous administration. Recently, we demonstrated that tocotrienol-rich fraction entrapped in transferrin-bearing vesicles led to an …
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Host-defence peptides from frog skin secretions: identification and bioactivity evaluation and optimisation
With the rapid development of antibiotic resistance, new types of antimicrobial drugs are urgently needed. A novel AMP, Brevinin-1H, was isolated from skin secretion of Amolops hainanensis (A. hainanensis) with broad spectrum antimicrobial activity, anti-proliferative activity, and strong …
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An investigation into the anti-cancer mechanism of garlic-related organosulfur compounds
… showed a positive correlation between the anti-proliferative-IC50 of disulfides and the relative stability of their anion leaving groups, as assessed through resonance and quantified by predictive pKa-values.
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Functional and structural uncoupling of the angiogenic and enzymatic inhibitory activity of TIMPs : loop 6 of TIMP-2 is a novel inhibitor of angiogenesis
… were conducted to identify and characterize the anti-angiogenic domains of TIMP-2, the endogenous MMP inhibitor that uniquely inhibits capillary endothelial cell (EC) proliferation and angiogenesis in vivo. Only the carboxy-terminal domain of TIMP-2 (T2C) and not the MMP-inhibitory N-terminal …
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SOX7 is downregulated and functions as a tumor suppressive transcription factor in breast cancer
… tumor suppressor function and, consequently, an anti-proliferative cellular state.
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The Cellular and Molecular Properties of Flavinoids in Prostate Cancer Chemoprevention
… thesis describes the identification of novel anti-proliferative flavonoids, their molecular effects on cell cycle and related proliferation and survival pathways, and their chemopreventive properties in a murine model of prostate carcinogenesis. We identified several novel flavonoids with …
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Chemical, Biological, and Preliminary In Vitro Studies of Novel Vanadium(IV) Complexes with Schiff Bases and Thiosemicarbazone Ligands
… were observed to exhibit anti-proliferative activity against three colon cancer cell lines, HTC-116, Caco-2, and HT-29. When the anti-proliferative effects were compared with that of non-cancerous colonic myofibroblasts, less inhibition was observed. The results obtained …
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Effects of modified bioactive pectins on colon cancer cells in vitro
… with pH, heat or enzymes, has been shown to have anti-cancer activity in several cancer cell lines. The galactan chains of MP are postulated to be essential for bioactivity due to their ability to bind and inhibit the pro-metastatic protein galectin-3 (Gal3) on cancer cells. However, the …
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Synthesis and biological evaluation of potential anti-cancer agents
… used to prepare a large number of compounds of anti-cancer screening. A library of caffeic acid derivatives has been prepared by the Knoevenagel condensation of aldehyde and active methylene reagents. These products have been screened against two murine adenocarcinoma cell lines (MAC) which are …
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Molecular mechanisms involved in the anticancer activity of BISPMB in oesophageal cancer cells
… siRNA mediated knock-down of CHOP abolished the anti-proliferative effect of bisPMB in WHCO1 cells. However, inhibition of JNK and p38 MAPK by chemical inhibitors, SP600125 and SB 203580 respectively, had no effect on bisPMB antiproliferative activity against WHCO1 cells. On the other hand, …
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An investigation into the role of TBX3 in breast carcinogenesis and its regulation by the TGF-?1 signalling pathway
… signalling pathway mediates the TGF-β1-regulated anti-proliferative and pro-migratory effects. Furthermore, this study demonstrates that TBX3 mediates the anti-proliferative function of TGF-β1 through repressing transcription of its homologue, TBX2, which allows for the de-repression of p21 and a …
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