Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"anti-proliferation activity"”.
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Identification and functional study of the antimicrobial peptide, QUB- 1985, from the skin secretion of the large odorous frog, Odorrana livida
Nowadays, antimicrobial resistance is one of the most serious health threats around the world. Therefore, novel antimicrobial agents are urgently needed to alleviate the pressure on conventional antibiotics. Antimicrobial peptides (AMPs) are widely known for their potent activity towards a broad …
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A bioactive peptide from the defensive skin secretion of <i>Odorrana versabilis</i>
… of QUB-1966 was synthesised and the biological activity of this synthetic peptide was further evaluated through multiple biological assays. These found that QUB-1966 exhibited moderate antimicrobial effects against the Gram-negative bacterium, Escherichia coli (E. coli), the Gram-positive …
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A Structure-Activity Relationship Study of Dihydroajoenes as Anti-Cancer Agents
… garlic is known to possess in vitro and in vivo anticancer activity based on the presence of a vinyl disulfide as its pharmacophore. This thesis reports on the synthesis of dihydroajoenes, a novel set of ajoene analogues, containing a saturated double bond, in which the intention was to study the …
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QUB-1904: A Bioactive Peptide from the Frog Skin Secretion of Pelophylax esculentus
… functions, such as for suppress cancer cell proliferation and decrease inflammatory responses, etc. Recent developments in the field of BBIs have led to a renewed interest in amphibian skin-derived BBIs which have a much shorter chain and remarkable inhibitory effect. <br/><br/>In this study, …
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Identification and functional study of a bioactive peptide QUB-2558 from the skin secretion of the Wuyi torrent frog, Amolops wuyiensis
… of their unique habitats and metabolic pathways. Antimicrobial peptides (AMPs), one of the natural products from amphibians, have become the research hotspot as new substitutes for antibiotics. This paper mainly focuses on analysing the structural characteristics and the biological activity of …
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Identification, molecular cloning and modification of skin-derived bioactive peptides from selected Hylidae and Ranidae
… researchers in recent years. Many peptides show antimicrobial activity to different extents and are less prone to induce bacterial resistance. However, during the evaluation of therapeutic potential, the unfavorable factors of peptides were revealed like modest MIC values relative to conventional …
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Characterisation of a novel bioactive complex polysaccharide from a marine invertebrate with potent anticancer and antimalarial activities
… mammalian GAG and investigates their biological activity in relation to cancer and malaria. Glycans from marine sources are unique in terms of their structure and function. They work as an alternative natural source to provide effective treatment for several types of cancer, especially triple …
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Identification and functional study of a bioactive peptide QUB-2007 from the skin secretion of the bicolour tree-frog Phyllomedusa bicolor
Antimicrobial peptides secreted in amphibian skin secretions have many important bioactivities and act as the first line of defence against invading microorganisms. In this thesis, QUB-2007, a peptide belonging to the Phylloseptin family of the Dermaseptin superfamily, was derived from the skin …
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Design, Synthesis and Biological Screening of Novel Cucsinspired Estrone Analogues Towards Treatment of Hepatocellular Carcinoma
… with different biological activities, such as anti-inflammatory, hepatoprotective and anti-cancer. Hepatocellular carcinoma (HCC) is the third leading cause of death worldwide. Previous reports have shown the ability of CUCS to inhibit the growth of hepatocellular carcinoma cell lines (HepG-2) …