Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"anti-proliferation"”.
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Anti-proliferation safeguard system for General Electric's PRISM reactor plant
The proliferation resistance of a nuclear power plant has become an increasingly important issue due to the political climate of nuclear power at the present. Any new power plant that is constructed must be proliferation resistant and meet international standards set by the International Atomic …
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Identification and functional study of the antimicrobial peptide, QUB- 1985, from the skin secretion of the large odorous frog, Odorrana livida
Nowadays, antimicrobial resistance is one of the most serious health threats around the world. Therefore, novel antimicrobial agents are urgently needed to alleviate the pressure on conventional antibiotics. Antimicrobial peptides (AMPs) are widely known for their potent activity towards a broad …
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Subcultures, the Media and the Law: The Creation and Mystification of the Rave Scene
… promoters through passing of the Illicit Drug Anti-Proliferation Act
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Platforms for Biological Control
… is the only DNA screening concept to prioritize anti-proliferation of pathogen genomes, and the first to employ modern cryptography to secure a global screening system that can keep up with anticipated exponential growth of the DNA synthesis market. For each platform developed, a software …
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Sythesis and Biological Screening of a Series of Novel Chemokine Receptor CCR5 Antagonists
… indication of its CCR5 receptor antagonism. The anti-proliferation assay was performed to measure the ability of these new compounds to inhibit the proliferation of prostate cancer cell lines, PC-3 and M12. A new lead compound has been identified which showed micromolar level of inhibition to …
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SYNTHESIS AND BIOLOGICAL EVALUATION OF SECOND GENERATION ANIBAMINE ANALOGUES AS NOVEL ANTI-PROSTATE CANCER AGENTS
… in 2004, has been found to have significant anti-prostate cancer activity at micromolar level. To optimize this compound and also discover a novel pharmacophore, exploration of the original structure was carried out. Significant modifications were made to the side chain in the original …
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A bioactive peptide from the defensive skin secretion of <i>Odorrana versabilis</i>
… These found that QUB-1966 exhibited moderate antimicrobial effects against the Gram-negative bacterium, Escherichia coli (E. coli), the Gram-positive bacterium, Staphylococcus aureus (S. aureus) and the yeast, Candida albicans (C. albicans) with minimal inhibitory concentrations of 128 μM, 64 …
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Containment building : architecture between the city and advanced nuclear reactors
… increasing fuel prices, carbon emissions, and anti-proliferation movements have brought the discussion of clean, safe nuclear power to the forefront of American energy policy; it is no longer tolerable or sustainable to rely on a uranium (U) nuclear network. The architectural typology of …
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Characterisation of a novel bioactive complex polysaccharide from a marine invertebrate with potent anticancer and antimalarial activities
… for its biological activity on cancer growth. Anti-proliferation activity on several cancer cells, including pulmonary adenocarcinoma A459, the MCF-7 ER-positive cell line, overexpression of protein HER2- SKBR3 cell line, the hepatoblastoma-derived cell line (Hep G2), chronic myelogenous …
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Characterization of Mycochemicals and Bioactivities of a New Zealand Native Mushroom Hericium novae-zealandiae
… method was subsequently applied for the quantification of the identified compounds. In addition, the bioactivities of the extracts and the compounds were evaluated in relation to anti-proliferation of three prostate cancer (PCa) cell lines (DU145, LNCaP, and PC3), AChE inhibition and …
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A Structure-Activity Relationship Study of Dihydroajoenes as Anti-Cancer Agents
… garlic is known to possess in vitro and in vivo anticancer activity based on the presence of a vinyl disulfide as its pharmacophore. This thesis reports on the synthesis of dihydroajoenes, a novel set of ajoene analogues, containing a saturated double bond, in which the intention was to study the …
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Self-protection analysis of denatured thorium-plutonium fuel
… capabilities of this fuel type, for anti-proliferation purposes. In particular, there were two proliferation-resistance methods that were analyzed. First, this study examined the time-dependant dose-rate of the spent fuel caused by the decay of the isotope uranium-232, which releases …
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Identification and functional study of a bioactive peptide QUB-2558 from the skin secretion of the Wuyi torrent frog, Amolops wuyiensis
… of their unique habitats and metabolic pathways. Antimicrobial peptides (AMPs), one of the natural products from amphibians, have become the research hotspot as new substitutes for antibiotics. This paper mainly focuses on analysing the structural characteristics and the biological activity of …
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QUB-1904: A Bioactive Peptide from the Frog Skin Secretion of Pelophylax esculentus
… functions, such as for suppress cancer cell proliferation and decrease inflammatory responses, etc. Recent developments in the field of BBIs have led to a renewed interest in amphibian skin-derived BBIs which have a much shorter chain and remarkable inhibitory effect. <br/><br/>In this study, …
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Bioactivity evaluation and structural modification of Bowman-Birk type protease inhibitory peptides from amphibian skin secretions
… trypsin and tryptase inhibitory activity and antimicrobial activity. When the lysine residue at P1 site was replaced by phenylalanine, the forming peptide F8-BBI-PPF exhibited strong chymotrypsin inhibitory activity but totally lost the trypsin inhibitory activity. In Chapter 4, pLR-HR, which …
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Identification, molecular cloning and modification of skin-derived bioactive peptides from selected Hylidae and Ranidae
… researchers in recent years. Many peptides show antimicrobial activity to different extents and are less prone to induce bacterial resistance. However, during the evaluation of therapeutic potential, the unfavorable factors of peptides were revealed like modest MIC values relative to conventional …
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Investigation of porcupine bezoar extract (Hystrix Brachyuran) on hela cell combined with electroporation method
… for pulse duration, where it inhibits the lowest proliferation rate percentage of HeLa cell. For the natural resource compound or extract which is available in Malaysia Porcupine Bezoar (Hystrix Brachyuran) were used. This extract has the potential as an anti-proliferation agent, which is useful …
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Study of low voltage electroporation technique on hela cell treated with neolamarckia cadamba extracts daing
… was proven by the reduction in the percentage of anti proliferation of HeLa cell where with electroporation 30.08% cell can survive and by combining electroporation and extact of Neolamarckia Cadamba leaves only 2.12% HeLa cell can survive.
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DEVELOPMENT OF ANTAGONISTS TARGETING CHEMOKINE RECEPTOR CCR5 AND THE CHEMOKINE RECEPTOR CCR5 – MU OPIOID RECEPTOR HETERODIMER
… were tested for their CCR5 antagonism and their anti-proliferative effects in several prostate cancer cell lines. The data from both the calcium mobilization studies and the anti-proliferation studies suggests that the compounds synthesized have activity as CCR5 antagonists and as …
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Investigation of S1P and S1P Signaling in Adipocytes and Adipocyte-Breast Cancer Cell Interaction
… product of sphingolipid metabolism, affecting proliferation, apoptosis, inflammation, and angiogenesis. Common therapeutic strategies for targeting S1P in cancers showed little successful progress. In contrast, data have shown the pro-apoptotic and anti-proliferation effect of S1P on breast …
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