Global ETD Search
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Showing 1 to 5 of 5 for “"anti-prion"”.
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Development of A High-Throughput System For Screening of Anti-Prion Molecules
<p>The misfolded prion protein causes and transmits disease in both humans and animals. As other infectious agents, prions display strain variation, which can generate different pathological outcomes in affected individuals. Unfortunately, there are no known therapies for these diseases, which at …
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Prions Propagate as Dynamic Strain Mixtures
Prions are the agent responsible for a group of transmissible and inevitably fatal neurodegenerative disease in humans and other mammals. Prion disease is caused by the misfolding of a host encoded protein, PrPC, into the infectious conformation PrPSc. Phenotypic differences in disease (i.e., …
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Use of the Protein Misfolding Cyclic Amplification for food safety and drug discovery
<p>Prion diseases are fatal neurodegenerative disorders caused by the misfolding of the normal prion protein (PrP<sup>C</sup>) into its infectious form (PrP<sup>Sc</sup>). While the zoonotic potential of chronic wasting disease (CWD) remains uncertain, the presence of prions in food products raises …
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Doxycyclin bei der sporadischen Creutzfeldt-Jakob-Krankheit
… neurodegenerative Erkrankung aus der Gruppe der Prionerkrankungen. Als zentraler pathophysiologischer Mechanismus wird die Ablagerung von pathologischem Prionprotein (PrPSc) angenommen, die zu Funktionsausfall und Zelltod im zentralen Nervensystem führt. Charakteristisch sind eine rasch …
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A genetic platform for the study of protein perturbation and prion-based inheritance
… output, the signal from yTRAP is readily quantifiable. The combination of these desirable properties enables many kinds of previously-impossible studies. Furthermore, because of its exquisite sensitivity, yTRAP can be used to broadly screen for protein perturbation beyond the context of …