Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"anti-phage defense"”.
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Anti-phage defense as a driver of molecular innovation
Bacteriophages, or phages for short, pose a near-constant threat to the bacteria they infect. Billions of years of conflict has been a catalyzing force for the creation of bacterial defense systems and corresponding phage evasion strategies. To counter phage predation, bacteria have developed a …
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Conflict between bacteriophages and a mobile genetic element in bacterial immunity
Bacteriophages (phages) are the most abundant biological entities on the planet. They are ubiquitous and numerous across the many environments bacteria are found. To combat phage predation, bacteria have evolved numerous immune strategies, so-called anti-phage defense systems. Likewise, phages …
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Ancient Immune Systems: Sensing and Signaling in Bacterial-Phage Conflict
… life on Earth. In the microbial world, bacteriophages (phage) are bacterial viruses and drive a continuous evolutionary arms race that has led to an extraordinary diversity of bacterial defense mechanisms [1]. These systems are thought to have provided the evolutionary foundation for numerous …
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Recombination and Excision: DNA Repair Proteins in Prokaryotic Host-Virus Conflicts
<p>Bacteriophages, or simply phages, are viruses that infect bacteria. They are the most abundant biological entity on our planet and outnumber bacteria 10:1 in the ocean. In response to this threat, bacteria have evolved a diverse battery of immune systems that prevent infection, which in turn has …
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Evolution and engineering of protein-protein interactions
… to inform the design of protein binders to toxin-antitoxin systems. These binders are selective in their interactions with toxin homologs, and inhibit toxin-antitoxin-mediated bacterial anti-phage defense activity, suggesting their potential use in clinical phage therapy applications. Taken …
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Mechanisms and applications of anti-phage defenses in staphylococci
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-05-01
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Restriction-Modification and CRISPR-Cas Systems: Cooperation Between Innate and Adaptive Immunity in Prokaryotes
… the constant assault of viruses (called bacteriophages, or simply phages) that can infect and kill them. Restriction-modification (RM) systems represent one such strategy. Generally, these systems provide defense by coordinating the activities of two distinct enzymes: a restriction endonuclease …
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Roles of non-Cas nucleases in Type III-A CRISPR-Cas immunity
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-08-01