Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"anti-fungal"”.
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The anti-fungal and anti-oxidant properties of polyphenols extracted from the resurrection plant, Myrothamnus flabellifolia
In this study the effects of M. flabellifolia polyphenols on growth of S. cerevisiae yeast strains was investigated. This study showed that M flabellifolia polyphenols inhibited growth of both the wild type and the Δhsp 12 yeast strains largely by binding protein in the growth medium. A decreased …
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Establishment of hedgehog pathway overexpression in osteosarcoma cell lines leading to an anti-apoptotic genotype which can be inhibited by the common anti-fungal and hedgehog pathway inhibitor, itraconazole
… and animals and leads to overexpression of anti-apoptotic proteins including Bcl-2 and c-FLIP. This produces an anti-apoptotic genotype by influencing both the intrinsic and extrinsic arms of the apoptotic pathway. Itraconazole is an antifungal agent that has been found to inhibit Smoothened …
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Deciphering The C-Type Lectin Receptor Signaling Pathway In Macrophages In Response to Candida Albicans
<p><em>Candida albicans </em>causes opportunistic fungal infections in humans and is a significant cause of mortality and morbidity in immune-compromised individuals. Dectin-2, a C-type lectin receptor, is required for recognition of <em>C. albicans </em>by innate immune cells and is required for …
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PHARMACOKINETICS AND ORAL DELIVERY OF POLYMETHOXYLATED FLAVONES
… spectrum of pharmacological activities such as anti-inflammatory, anti-cancer, anti-diabetic, anti-bacterial, anti-fungal, blood thinning and neuro-protective effects have been reported extensively. To further evaluate the medicinal potentials of three polymethylated flavones, namely tangeretin …
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Investigating physiological collaborations between a lower termite and its symbionts
… and immunity. My efforts focused on 1) quantifying the role of bacteria in wood digestion within the termite gut, 2) evaluating the role of symbionts in protection against pathogens, and 3) identifying gene products that bacterial symbionts contribute to naïve and pathogen-challenged …
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Selective Borylations of Carbon-Carbon pi-Bonds
… this dissertation will cover the preliminary anti-fungal activity of a novel oxaborole scaffold. We investigated the borylation of the electron withdrawing allenoate scaffold. Reports in the literature were scarce and limited in the scope of the work or required the use of less available …
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Evolution of a salivary mucin, MUC7
… in saliva in placental mammals; (iii) the anti-fungal domain of the protein was remodified under positive selection in the primate lineage; and (iv) MUC7 PTS-repeats have evolved recurrently and under adaptive constraints. Our results establish MUC7 as a major player in salivary adaptation, …
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Herstellung, Expression und Charakterisierung von rekombinanten Antikörpern und Immuntoxinen gegen Phoma lingam, Sclerotinia sclerotiorum und Verticillium dahliae
… been accompanied by the increased incidence of fungal pathogens that attack rapeseed and other crop species. These include Phoma lingam, Sclerotinia sclerotiorum and Verticillium dahliae. Current methods for controlling these pathogens are limited to prophylactic use of fungicides. Current …
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Synthetic and computational investigations into reaction pathways towards complex heterocyclic ring systems
… (a promising anti-fungal agent) from the irradiation of 2,3a,4,6a-tetraphenyl-3,3a,4,5,6,6a hexahydropyrrolo-[2,3-d]-1,2,3-triazole. One of our main aims was to synthesise novel 1,2,3,5-tetrazocines that possessed three phenyl and one methyl group(s) attached to …
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Cellular Copper Import Mechanisms via Secreted Cuproproteins: Exploring Metal Homeostasis in Pseudogymnoascus destructans
… investigates the metal stress response of the fungal pathogen Pseudogymnoascus destructans (Pd), which causes White-Nose Syndrome in bats. Special emphasis is placed on understanding how cellular metal status effects Bim1-like Proteins (BLPs) and high-affinity copper transporters (CTR proteins) …
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An Analysis of the Response of Aspergillus fumigatus and Candida albicans to Caspofungin
… patients. Caspofungin is a recently introduced antifungal compound that has good efficacy against these fungi with minimal side effects. The aim of the work presented here was to characterise the response of A. fumigatus and C. albicans to caspofungin. The results obtained demonstrated that …
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A functional genomics approach: Characterisation of two Non-ribosomal peptide synthetase genes, and investigation of an adaptive response towards alkylating DNA damage in Aspergillus fumigatus.
… to encode a structural peptide necessary for fungal recognition by the innate immune system; deletion of pes3 resulted in hypervirulence in both insect (p < 0.001) and murine (p = 0.02) models of invasive aspergillosis, and increased susceptibility to voriconazole (p < 0.001). The NRP …
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Identification and evaluation of bioactive peptides from amphibian skin and rational design of new analogues
Human demand for novel antimicrobials has increased due to the rapid development of antibiotic-resistant bacteria. Because of their remarkable antimicrobial capacity, antimicrobial peptides are at the forefront of new antibacterial drugs. In our research, we are working with the isolation and …
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Synthetic Study Of Karlotoxins And Investigation Of Alpha-Diaminoboryl Carbanion Chemistry
… activities such as hemolytic, cytotoxic, and anti-fungal activities. Recently, the Hamann group successfully assigned the absolute configurations of KmTx2, the first complete structure elucidation among the congeners. In a structural sense, karlotoxins are a family of linear polyketides with …
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Functional Genomic Analysis of Natural Product Biosynthesis and Secretion in Aspergillus fumigatus
… either pes1 or sidD significantly improved fungal tolerance to anti-fungal drugs (amphotericin B and voriconazole, respectively) which strongly suggests that either gene may play a role in mediating drug resistance/tolerance in patients. It was found that under oxidative stress conditions …
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Virulence and Biofilm Formation In Candida Albicans Are Inhibited By Short Peptide Subunits of Entv
… albicans</em>, the most clinically significant fungal pathogen, commonly causes topical mucosal infections such as oral cavity and urogenital tract infections. It also less frequently causes severe invasive and bloodstream infections. Invasive infections are most prevalent amongst patients with …
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Analysis of the effect of atorvastatin on the virulence of Fungal Pathogens
Fungal pathogens of humans cause harmful infections and can cause diverse diseases in humans which range from superficial skin infections to life-threatening diseases. The opportunistic pathogen Candida albicans causes a wide range of diseases primarily in immunocompromised individuals. Aspergillus …
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Characterising the response to gliotoxin exposure in Aspergillus fumigatus ΔgliT and ΔgliZ
The non-ribosomal peptide gliotoxin, is a toxic fungal secondary metabolite produced by the filamentous fungus Aspergillus fumigatus. Previous work has implicated its potent anti-fungal properties and importance as a virulence factor in human infection. Availability of the A. fumigatus genome has …
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Changes in litter inputs and decomposition in headwater streams during a mountain pine beetle infestation of whitebark pine
… headwater streams. To test these predictions I quantified the mode of transport and rate of litter inputs to headwater streams in the GYE within ten streams distributed between two basins of differing levels WbP mortality and surveyed benthic invertebrate populations within those streams to …
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