Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"anti-drug antibodies"”.
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Interactions of Lysergic Acid Diethylamide and a Lysergyl Metabolic Derivative With Anti-Drug Antibodies
Made available in DSpace on 2014-12-11T18:16:56Z (GMT). No. of bitstreams: 1 7500360.pdf: 4655618 bytes, checksum: ad15fd165f98af6f38333c073497eca2 (MD5) Previous issue date: 1974
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Optimisation of analytical methods for monitoring monoclonal antibody therapy in Inflammatory Bowel Disease
… can be successfully treated with the monoclonal antibody therapies Infliximab and adalimumab. However, low drug levels and immunogenicity (development of anti-drug antibodies) are associated with treatment failure. Therapeutic drug monitoring, using drug and anti-drug antibody measurements …
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Therapeutic drug monitoring of anti-TNF biologics in patients with Crohn's disease at Groote Schuur Hospital, Cape Town, South Africa
Monoclonal antibodies targeting Tumour Necrosis Factor-α (TNF α) have revolutionised the management of Inflammatory Bowel Disease (IBD) and have proved highly effective in both inducing and maintaining remission in both ulcerative colitis (UC) and Crohn's disease (CD). The advent of Therapeutic …
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Development of immunogenicity models in mice for improved risk assessment of biopharmaceuticals
The development of anti-drug-antibodies (ADA) to biopharmaceuticals, e.g. recombinant proteins including monoclonal antibodies (mAb) can lead to adverse events and clinical complications. These include reduced effect of the drug and autoimmune conditions if the administered drug is analogous to …
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The Development of Methods to Account for Physiologic Dynamic Changes and Their Effects on the Pharmacokinetics of Therapeutic Monoclonal Antibodies and other Therapeutics
… an immune response to a therapeutic monoclonal antibody (mAb). Several approaches can be used to limit or capture the changes in the pharmacokinetics of a medication caused by ontogeny and immune reactivity related dynamic changes. Three approaches were investigated in this dissertation: 1) …