Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 85 for “"anti-diabetic"”.
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Anti-diabetic properties of GUH
Objective: To investigate anti-diabetic properties of the plant extract known as GUH in comparison to commercially available drugs metformin and rosiglitazone. Methods: Male Wistar rats were fed a maintenance diet (MD) with tap water or a high fat diet (HFD) with sucrose solution for a period of …
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Ranolazine: a Potential Anti-diabetic Drug
… hematoxylin and eosin or stained with insulin antibody for islet mass evaluation. INS1-832/13 cells and human islets were further used to evaluate the effect of ranalozine on beta-cell survival and related signaling pathway. Fasting blood glucose levels after the fourth week of STZ injections …
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Baicalein, a novel anti-diabetic compound
… claimed beneficial effects on health, such as anti-oxidant, anti-viral, anti-thrombotic, and anti-inflammatory effects. However, it is unclear whether it exerts an anti-diabetic action. Here, we present evidence that baicalein may be a novel anti-diabetic agent. Specifically, dietary intake of …
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Synthesis of sulfonylthioureas as anti-diabetic drugs
… and sulfonylthiourea can potentially be used as anti-diabetic agents.
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The anti-diabetic mechanisms by isoflavone genistein
… animals and humans. However, the potential anti-diabetic mechanisms of genistein are unclear. In the present study, we first investigated the effect of genistein on β-cell insulin secretion and proliferation and cellular signaling related to these effects in vitro and in vivo. We then …
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Synthesis of Glitazone Analogues as Anti-Diabetic Drugs
… synthesized compounds, 36f exhibited excellent antidiabetic activities against α-glucosidase. Compounds 36a, 36b, 36i and 36j also displayed good activities and have potential to be further investigated whereas compounds 36c, 36e, 36g and 36h exhibited moderated activities against α-glucosidase. …
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Chemical strategies for improving anti-diabetic glucagon therapy
… to the patient as and when needed in the right quantities, similar to how pancreas delivers the hormones naturally. Many studies have shown that such automated systems better maintain the health of the patient. In this work, two chemical approaches are taken to engineer glucagon to have ideal …
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Investigating the potential anti-diabetic effect of sulforaphane
Type 2 diabetes (T2D) is a major public health issue worldwide and it currently affects nearly 26 million people in the United States. It is estimated that one third of Americans will have diabetes by 2050. T2D is a result of chronic insulin resistance and loss of beta-cell mass and function. Both …
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Intestinal absorption and metabolism of bush tea major phenolic compounds exhibiting anti-diabetic activity.
Athrixia phylicoides (A. phylicoides), popularly known as ‘bush tea’, is an indigenous aromatic shrub found in mountainous and grassland areas of the northern and eastern parts of Southern Africa. The plant is traditionally used for the treatment of several ailments, including coughing, treating …
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Effects of Ultrasonication on the Antioxidant and Anti-diabetic Properties of Hydrolyzed Oat Proteins
… proteases produced hydrolysates with notable antidiabetic activity (DPP-4 and alpha-amylase inhibition) but this was not influenced by the difference in polypeptide compositions.
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Anti-Diabetic and Anti-Obesity Activities of Cocoa (Theobroma cacao) via Physiological Enzyme Inhibition
… levels caused by processing affect cocoa's anti-diabetic and anti-obesity bioactivities, such as inhibition of certain enzymes in the body. Polyphenol profiles, protein-binding abilities, presence of compounds termed oxidative polymers, and abilities to inhibit α-glucosidase, pancreatic …
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Identification of a Dual-Action Small Molecule with Potent Anti-diabetic and Anti-obesity Activity
… less than one in four patients treated with anti-diabetic drugs achieved the glycemic target. Thus, identifying more effective anti-diabetic drugs is still needed for improving glycemic control in T2D patients. Incretins are gut hormones that possess potent insulinotropic action, which have …
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The Design, Synthesis, and Evaluation of (I) Arylpiperazines and (II) Pyrazolopyrimidinones as potential anti-diabetic agents
… of heterocyclic compounds that have potential as anti-diabetic agents. We postulated that an anti-diabetic effect might be achieved through the inhibition of complex I of the electron transport chain, which would make oxidative phosphorylation less efficient, and therefore require increased …
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Isolation and characterisation of anti-diabetic pharmacological activities of phytoestrogens and components of Moringa peregrina (Forssk) Fiori
… members of the Moringa family have recorded anti-diabetic family and Moringa peregrina was chosen for investigation in this work with the aim of characterising anti-diabetic activity from its leaves. Six extracts were prepared using solvents water, methanol, butanol, ethyl acetate, chloroform …
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Prevalence of Anti-diabetic and Antilipidemic Medications in Children and Adolescents treated with Atypical Antipsychotics in a Virginia Medicaid Population
Objective: To determine if the prevalence of anti-diabetic and antilipidemic medication use among children treated with atypical antipsychotics is higher than those not treated with antipsychotics. Methods: Virginia Medicaid beneficiaries (2-17 years) continuously enrolled from August 1, 2010 to …
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A systematic review of interventions to improve adherence to anti-diabetic medications in patients with type 2 diabetes in sub-Saharan Africa
… a systematic review that aims to undertake a quantitative review of interventions to improve adherence to anti-diabetic medications for adults with type 2 diabetes in subSaharan Africa, and the impact of these interventions in achieving good glycaemic control. For the evaluation of these …
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In-vivo and in-vitro study of mechanism of action of 4 hydroxyisoleucine as an amino acid derived from fenugreek seed with anti-diabetic and properties
… used in South Asia and Europe, are known to have anti-diabetic properties. In 1979, Hardman identified an unusual amino acid (2S, 3R, 4S) 4-hydroxyisoleucine (4HO-Ile) in a fenugreek seed extract as an active compound in fenugreek seed. It was so far found only in fenugreek seed, which is …
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