Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"anti-coagulation"”.
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Designing Allosteric Inhibitors of Thrombin
Thrombin is a key enzyme of the coagulation cascade exhibiting important roles in both pro-coagulation and anti-coagulation processes. Most clinically used anticoagulant drugs, including polymeric heparin, warfarin, hirudin, argatroban and the recently approved dabigatran, aim to reduce thrombin …
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Human ceruloplasmin gene and cDNA
… include copper transport, serum and tissue anti-oxidant and anti-coagulation modulation. The cDNA of ceruloplasmin sharehomology with the cDNAs of factors V and VIII of the blood coagulation cascade,suggesting that the three genes evolved from a common ancestral gene. Thereare two …
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Microfluidic Approaches to Thrombosis and Hemostasis: Towards a Patient-Specific Test of Antiplatelet Therapeutics and the Assessment of Coagulopathy in Hemophilic and Trauma Patients
… for the study of platelet deposition and coagulation using minimum volumes of human whole blood. This dissertation describes the application of microfluidic assays, the manipulation of surface-patterned procoagulant and sub-endothelial proteins, anti-coagulation, and flow conditions to …
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Differential gene expression and immune regulatory mechanisms in parasite-resistant hair and susceptible wool sheep infected with the parasitic nematode, Haemonchus contortus
… survival, endosome function, gut motility, and anti-coagulation pathways are important in abomasal and lymph node tissues during H. contortus infection. Immune genes, including IL-4, IL-4 Ra, IL-12 Rb1, and IL-12 Rb2, are also highly represented in abomasal or lymph node tissue of infected …
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INVESTIGATION OF THE MIALOME OF IXODES SCAPULARIS REPLETE TICKS AND UNDERSTANDING THE POPULATION GENOMIC STRUCTURE OF IXODES PACIFICUS TICKS
… analyses. Immunization of hosts with targeted anti-tick vaccines would ideally lead to a reduction in tick numbers and prevent transmission of tick-borne pathogens. Vaccines using cattle tick antigens (anti-tick vaccine) have proven to be cost-effective and environmentally friendly for the …
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Audit of the quality and cost of acute inpatient stroke care in the general medical wards at Groote Schuur Hospital
… with ischaemic stroke received inpatient antiplatelet or anti - coagulation therapy, not all risk factors were adequately addressed on discharge. The median cost of a stroke admission was R19,072.07 (IQR R10,899.85 to R27,789.43 ). The strongest correlation with cost 12 was with length of …
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Application of passive flow control to mitigate the thromboembolic potential of bileaflet mechanical heart valves: an in-vitro study
… risk of thromboembolic complications despite anti-coagulation therapy. Mechanical heart valves have been the gold standard in valve heart replacement since the 1950s with BMHVs currently still being the valve of choice for younger patients. Given that a large body of literature points to …