Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"anti-cancer therapy"”.
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Discovery and Characterization of Novel Chemical Inhibitors of Wnt Ligand Production with Implications for Anti-Cancer Therapy
… has been uncovered in adult stem cell niches and cancers arising from associated tissues. Consequently, interest has shifted towards achieving chemically based control over aberrant pathway responses, with the ultimate goal of creating therapeutic utility. To this end our laboratory screened a …
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Development of in vivo tumour models for non-invasive proof-of-principle investigation of novel therapeutic agents. Engineering and characterisation of bioluminescent cell reporter systems for in vivo analysis of anti-cancer therapy pharmacodynamics.
Despite significant advances in cancer treatment, clinical response remains suboptimal and there is a continued requirement for improved chemotherapeutics. The attrition rate for new therapies is high, due principally to lack of in vivo efficacy and poor pharmacodynamics. Consequently better …
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OPTICAL COHERENCE TOMOGRAPHY FOR NEUROSURGEY AND CANCER RESEARCH
… and novel imaging algorithms for monitoring anti-cancer therapy have been pursued in this work. A forward-imaging needle-type OCT probe was developed which can fit into minimally invasive tools (I.D. ~ 1mm), detect the at-risk blood vessels, and identify tissue micro-landmarks. This promising …
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Synthesis of Biologically Active Cytoprotective and Anticancer Small Molecules
Cancer is the most common cause of disease-related fatalities in the United States of America. It is estimated that more then half a million people per year will die from various forms of cancer. One of the defining characteristics of cancer is an uncontrollable growth of cells. Regardless of its …
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The Endoplasmic Reticulum Udpase ENTPD5 Promotes Cancer Cell Growth and Survival in the PI3K/PTEN
… activating AKT are commonly observed in human cancers. Activation of AKT and downstream PI3 Kinase signaling promotes protein translation, resulting in increased protein flux into ER; this will lead to decreased efficiency of protein folding and accumulation of unfolded proteins in the ER and …
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Development of Hif-1Α/Hif-1Β Heterodimerization Inhibitors Using A Novel Bioluminescence Reporter Assay System For In Vitro High Throughput Screening and In Vivo Imaging
… inhibitors may provide a novel approach to anti-cancer therapy. To this end, a novel approach for imaging HIF-1α/β heterodimerization <em>in vitro </em>and<em> in vivo </em>was developed in this study<em>.</em> Using this screening platform, we identified a promising lead candidate and …
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rRNA transcription as potential therapeutic target in triple negative breast cancers
Cancer has been identified as a group of diseases characterized by abnormal cell growth. In eukaryotic cells, the nucleolus is the region of the nucleus where initial stages of ribosome production occur. These stages include synthesis of ribosomal RNAs by RNA Polymerase 1 (RNAP1) followed by its …
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Attachment of polyelectrolyte multilayers to cells and the implications on cell behavior
… of using these cell backpacks as a targeted, anti-cancer therapy was evaluated by studying the effects on mouse monocytes. Finally, thin films containing maleimide groups were developed for the cell backpacks to covalently attach these polymeric patches to cell surfaces. Former cell surface …
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Mechanisms of Reversible Sorafenib Resistance in Hepatocellular Carcinoma
… a stable and heritable phenotype due largely to cancer cell acquisition of genetic alterations. Thus, most cancer agents are given as sequential lines of therapy since continued use of the same agent is considered futile after disease progression. The anti-angiogenic tyrosine kinase inhibitor …
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Glutamine Antagonism and Its Utlity [sic] as a Therapeutic Modality in Cancer
Glutamine metabolism is important in cancer as it fuels the TCA cycle, plays a role in redox homeostasis, and contributes to the production of nucleotides, amino acids, and lipids for survival, making glutamine metabolism a promising target in cancer therapy. The work outlined in this dissertation …
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Microrna Regulation of Prostate Cancer Stem/Progenitor Cells and Prostate Cancer Development
… of cells with stem cell properties, called cancer stem cells (CSCs), which are believed to be responsible for tumor establishment, metastasis, and resistance to clinical therapy. It’s crucial to understand the regulatory mechanisms unique to CSCs, so that we may design CSC-specific …
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Investigating the Role of RNA-Binding Proteins in Tumor Response to DNA Damage-Inducing Chemotherapy
… in the biological understanding and treatment of cancer over the past several decades, cancer remains a leading cause of mortality worldwide. Even with the emergence of molecularly-targeted therapies and immunotherapy, cytotoxic agents that induce DNA damage remain first-line drugs in the clinic. …
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Development and application of a general method for somatic cell genetics
… screens across many more cell lines and cancer types. Overall, these studies revealed a large set of common essential genes involved in housekeeping processes but, interestingly, also pinpointed differences specific to each cell line that reflected its developmental origin, oncogenic …
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The Role of Nutrient Availability in Therapeutic Response of Leukemia
<p>Tumor environment influences the response to anti-cancer therapy, but which extracellular nutrients impact drug sensitivity is largely unknown. In this work, we used functional genomics to identify metabolic modifiers of the response to L-asparaginase (ASNase), a therapy that depletes plasma …
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PORPHYRIN DERIVATIVES AS VERSATILE PROTEASOME MODULATORS
… has become a pharmacological target for cancer and neurodegenerative diseases where opposite effects are desirable, inhibition and activation respectively. Interestingly, accumulation of the ubiquitin-conjugated proteins, which have been tagged for degradation, but not efficiently …
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Role of CD47 In Red Cell Apoptosis (Eryptosis)
… Moreover, CD47 is reported to be upregulated in cancer cells allowing them to escape immune surveillance by binding to SIRP alpha on macrophages. The aims of this thesis were to evaluate and to confirm the presence of CD47 isoforms in erythroid and erythroleukemic cells, identify new CD47 binding …
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The therapeutic/anti-carcinogenic effect of cord blood stem cells-derived exosomes in malignant melanoma
Malignant melanoma is an invasive type of skin cancer with high mortality rates, if not detected promptly. The mortality trends are generally linked to multiple dysplastic nevi, positive family history, genetic susceptibility and phenotypic features including fair skin, freckles, numerous atypical …
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The therapeutic/anti-carcinogenic effect of cord blood stem cells-derived exosomes in malignant melanoma
Malignant melanoma is an invasive type of skin cancer with high mortality rates, if not detected promptly. The mortality trends are generally linked to multiple dysplastic nevi, positive family history, genetic susceptibility and phenotypic features including fair skin, freckles, numerous atypical …
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Evaluation of indigenous Namibian mushrooms and plants for antimalarial properties
… are non-degradable in nature. The current antimalarial drugs are also facing the specter of parasite resistance, hence the need to discover novel drugs from natural products. The overall objective of the study was to perform bioassay-guided fractionation and determine the antiplasmodial …
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The discovery and characterization of anticancer procaspase activating compounds
One key hallmark of cancer is its ability to evade apoptotic cell death. In normal cells, the apoptotic intrinsic and extrinsic pathways converge on the activation of executioner cysteine aspartate proteases caspases-3 and -7. However, cancer cells are able to escape apoptosis through mutations …
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