Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 19 of 19 for “"anti-cancer therapeutics"”.
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Development of exosome-based anti-cancer therapeutics
… (HCC) exosomes are found to be responsible for cancer progression, metastasis, and angiogenesis via cellular communications. However, studying cancer derived exosomes in vitro is limited, due to the way cell lines are grown in medium supplemented with foetal bovine serum (FBS) that contains …
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Defining the regulatory determinants in substrate catalysis by biochemical, biophysical, and kinetic studies for the development of specific small-molecule inhibitors of ubiquitin specific proteases 7 and 17
… of USPs has been implicated in many types of cancers where patients show significant elevation in cellular levels of specific USPs. This suggests that targeting specific upregulated members of the USP family in specific disease states would be ideal for the development of personalized …
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Enhanced Delivery of Gold Nanoparticles with Therapeutic Potential for Targeting Human Brain Tumors
… to the advancement and application of systemic anti-cancer therapeutics into the central nervous system. The structural and physiological delivery constraints of the BBB significantly limit the effectiveness of conventional chemotherapy, thereby making systemic administration a non-viable option …
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Investigating the cellular mechanisms that determine RNMT dependency in breast cancer cells
Breast cancer is the leading cause of cancer death in women worldwide. Although significant advances have been made in the treatment of breast cancer, new therapeutic approaches are required. Protein synthesis is often found to be deregulated in cancer and there has been significant effort into …
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NQO1-Bioactivatable Drugs at the Interface of Cancer Metabolism and the DNA Damage Response
… species (ROS) have been observed in multiple cancer types, where they are crucial for tumor biology. Concomitantly, tumor cells also have enhanced expression of antioxidant pathway proteins to detoxify excess ROS. Thus, a challenge for anti-cancer therapeutics is to fine-tune this delicate …
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The Molecular Mechanisms Underlying the Cancer Killing Effect of Interleukin-24
… cytokine that also displays specific anti-tumor effects across many cancer cell types. The tumor suppressor activities of IL-24 include inhibition of angiogenesis, metastasis, toxic autophagy, cancer-specific apoptosis, and sensitization to traditional cancer treatments like …
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Elucidation of the Proteases Responsible for and the Form of Soluble, Monomeric EphrinA1 Released From Cancer Cells
… months. Therefore, there is great need for novel therapeutics with the ability to target GBM cells and spare normal brain tissue. In a search for novel tumor-specific targets, ephA2 was identified as an up-regulated gene in GBM patients. Further analysis demonstrated the overexpression of the …
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Synthesis and Coordination Studies of Novel Heteroaryl Tetrazoles
… and their potential application as anti-cancer therapeutics are discussed. Carboxylate functionalised pyridyl tetrazole ligands were also synthesised and characterised. These ligands were examined for their potential to form coordination polymers. These investigations have been …
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Synthetic Degradable Polymer Systems for Drug Delivery
… tissues and minimize the side effects of new therapeutics; however, challenges remain due to the rapid clearance of drugs from the joint. Chapter 2 describes the study of a thermo-responsive injectable hydrogel for the controlled release of GSK3787, a potential disease-modifying therapeutic …
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BAD and Mcl-1 Regulation in Prostate Cancer
… the PKA, EGF, and PI3K/Akt pathways in prostate cancer cells. Upon phosphorylation of these residues, BAD becomes unable to bind to and inactivate the anti-apoptotic Bcl-2 subfamily, including Bcl-2 and Bcl-xL, allowing these proteins to carry out their pro-survival function. Treatment of C42 …
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The therapeutic/anti-carcinogenic effect of cord blood stem cells-derived exosomes in malignant melanoma
Malignant melanoma is an invasive type of skin cancer with high mortality rates, if not detected promptly. The mortality trends are generally linked to multiple dysplastic nevi, positive family history, genetic susceptibility and phenotypic features including fair skin, freckles, numerous atypical …
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The therapeutic/anti-carcinogenic effect of cord blood stem cells-derived exosomes in malignant melanoma
Malignant melanoma is an invasive type of skin cancer with high mortality rates, if not detected promptly. The mortality trends are generally linked to multiple dysplastic nevi, positive family history, genetic susceptibility and phenotypic features including fair skin, freckles, numerous atypical …
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Novel Insights into the Role of the Smoothened Cysteine Rich Domain in Hedgehog Signalling
… Hh signalling is associated with numerous cancer and tumor conditions. The Smoothened (Smo) G protein coupled receptor (GPCR) functions as the signal transducer of the Hh pathway and is the most attractive drug target of the pathway. The structure of the Smo receptor includes seven membrane …
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Investigation into ubiquitin signalling in response to cisplatin
Cisplatin is an anti-cancer drug that acts by introducing toxic DNA interstrand crosslinks into proliferating cells, causing both cytostatic and cytotoxic effects. Although various models of the interstrand crosslink (ICL) response have been proposed, none of them are complete and much still …
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Mechanical manipulation and visualization of single biomolecules using fluorescence spectroscopy
… GQs are widely studied as negative regulators of cancer-associated physiological machinery. Using our single molecule force-FRET assay, we demonstrated unprecedented heterogeneity in GQs, with at least six interconvertible species which differ in mechanical responses, but are largely resistant to …
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Achieving Cell-Specific Delivery of Multiple Oligonucleotide Therapeutics with Aptamer Chimeras
<p>Current standard cancer treatments such as chemotherapeutics, and radiation therapy are nearly as likely to kill the patient as cure the cancer. Therapies that have such a narrow window of efficacy are necessary for the treatment of aggressive diseases, but safer alternatives must be created. By …
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Cryo-EM as a Tool to Study the Diverse Interactome of Ku 70/80 in NHEJ and Beyond
… avenue for specifically targeting NHEJ in a cancer setting. Despite strong biochemical and cellular evidence of these interactions, there is limited information on their structural arrangement. Benefiting from the “resolution revolution” of cryo-electron microscopy (cryo-EM) (15), during my …
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Approaches for Microfluidics-Enabled, Bacterial, Single-Cell Synthetic Biology
… applications ranging from medicine (e.g. living anti-cancer therapeutics) to the transportation industry (e.g. antifouling agent-producing bacteria living on submerged hulls of ships). In these complex environments, engineered cells’ success or failure is defined by their individual as well as …
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Engineering kinetics of immunotherapies and vaccines
… and/or TLR-8, are of great interest as potential anti-cancer therapeutics due to their ability to activate innate immune cells. Nevertheless, safe and effective systemic administration of these compounds in the clinic is an unsolved challenge due to dose-limiting toxicities, poor bioavailability, …