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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 6 of 6 for “"anti-cancer drug target"”.

  1. Studies on cell growth promoting AKT signaling pathway – a promising anti-cancer drug target

    Mäemets-Allas, Kristina2016

    tartu

  2. The role of the transcription factor TBX2 in breast cancer and melanoma and its regulation by the UV-induced DNA damage pathway.

    Wansleben, Sabina MariaDepartment of Human Biology2013

    … factors that have gained prominence in cancer biology. For example, endogenous TBX2 is overexpressed in a growing list of cancers and when ectopically overexpressed it can bypass senescence and the tetraploidy checkpoints that protect against cancer. When the current study was initiated …

    cape-town Repository record

  3. Part 1 Design, Synthesis and Bioactivity of a Phosphorylated Prodrug for the Inhibition of Pin1; Part 2 Conformational Specificity of Cdc25c Substrate for Cdc2 Kinase using LC-MS/MS

    Zhao, SongVirginia Tech2007

    … observed to be overexpressed in a variety of cancer cell lines, and the inhibitors of Pin1 showed antiproliferative activities towards these cancer cells. These results implied that Pin1 might serve as a potential anti-cancer drug target. Besides, Pin1 has an important neuroprotective function …

    vt Repository record

  4. Design, Syntheses, and Bioactivities of Conformationally Locked Pin1 Ground State Inhibitors

    Wang, XiaodongVirginia Tech2005

    … isomerase involved in mitosis. As a potential anti-cancer drug target, Pin1 interacts and regulates the activity of an increasing number of cell cycle enzymes by an unknown mechanism. These cell cycle enzymes include Cdc25, Cdc27, Cyclin D1, Myt1, Wee1, NIMA, Cdc2, Plk1 and c-Myc. Recent …

    vt Repository record

  5. The Bca2 And Ampk Paradigm: Unraveling The Cancer Connection

    (buac) Ventro, Daniela2013

    … <strong>THE BCA2 & AMPK PARADIGM: UNRAVELING THE CANCER CONNECTION</strong> </p> <p>By</p> <p> <strong>DANIELA (BUAC) VENTRO</strong> </p> <p>December 2013</p> <p>Advisor: Dr. Q Ping Dou and Angelika M. Burger (deceased)</p> <p>Major: Cancer Biology</p> <p>Degree: Doctor of Philosophy</p> …

    wayne-thes Repository record

  6. Pin1 Inhibitors: Towards Understanding the Enzymatic Mechanism

    Xu, GuoyanVirginia Tech2010

    … with cyclin D1 levels, which contributes to cancer cell transformation. Overexpression of Pin1 promotes tumor growth, while its inhibition causes tumor cell apoptosis. Because Pin1 is overexpressed in many human cancer tissues, including breast, prostate, and lung cancer tissues, it plays an …

    vt Repository record