Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 76 for “"anti-cancer drug"”.
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Functional Interrogation Of Anti-Cancer Drug Resistance
… to achieve a precise map of each individual cancer’s genomic lesions, providing insights into the best strategies for treatment. However, these approaches will be undermined by cancer’s ability to resist upfront target inhibition (intrinsic resistance) as well as, in cases where tumors are …
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SERS & efficacy assessment of anti-cancer drug-nanoparticle conjugates
Non-small cell lung cancer (NSCLC) is the result of tumour development from genetically-mutated epithelial cells lining the surface of the lung. Clinical response to treatments is generally gauged by comparing tumour sizes pre- and posttreatment on computerised tomography. If no response is …
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Stable Polymer Micelle Systems as Anti-cancer Drug Delivery Carriers
… that might be used as ultrasonic-activated drug delivery carriers were synthesized and investigated. These polymeric micelle systems were Plurogel®, Tetronic®, poly(ethylene oxide)-b-poly(N-isopropylacrylamide) and poly(ethylene oxide)-b-poly(N-isopropylacrylamide-co-2-hydroxyethyl …
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REDOX-RESPONSIVE POLYMER DELIVERY SYSTEMS FOR ANTI-CANCER DRUG AND IMAGING
Cancer is one of the major human killers. Delivery systems for anti-cancer drugs and imaging agents play important roles in cancer treatment and diagnosis. For development of safe and efficient delivery systems, stimuli-responsive polymers which undergo significant physical or chemical properties …
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Synthesis of a Water Soluble Resveratrol Derivative as a Potential Anti-Cancer Drug.
<p>Research on development of water soluble anti-cancer drugs is one of the great challenges of modern medicinal chemistry. Resveratrol (Res) is one of the many phytoalexins producing stilbenoids present in several medicinal plants, grape skin, peanuts, and red wine. It has been found to exhibit …
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Development of Bioelectronic Technologies for the Investigation of Extracellular Vesicle Function and Anti-Cancer Drug Discovery
… in a field severely lacking in efficacious anti-metastasis treatments. Research into EV biology and function has seen a boom over the last decade owing to their unique features and potential clinical utility, and the demand for new and robust tools to study their functional activity has …
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!Development of small molecule therapeutics against anti-infectious and anti-cancer drug resistance via structure-based drug design
<p>!Drug discovery typically involves structure-based drug design based on three-dimensional protein structures and hit/lead compound identification and optimization. Herein, this technique was used to overcome several obstacles associated with the developing of antibiotics, anticancer agents, and …
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Peptide Targeting of Platinum Anti-Cancer Drug and Synthesis of Water Soluble Monofunctional Pt(II) Complexes Useful for Biological Labeling
… agent with various applications such as anti cancer agents. Several new targeted Pt(II) conjugates were synthesized having the NGR and LHRH targeting motif. The platinum conjugates bearing the NGR motif revealed selective delivery and destruction of cancer cells that had CD13 receptors …
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Development of a Human Lung Cancer Cytochrome C-GFP Reporter Cell Line to Study Anti-cancer Drug Responses in Apoptosis Pathways
… radiotherapy are the most popular methods for cancer treatments after surgery, but lack of specificity and are thus toxic to the healthy human cells. Studies have shown that targeted therapies have been linked to activation of apoptosis signal pathways (cascade of caspases) in cancer cells …
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Analysis of anti-cancer drug penetration through multicell layers in vitro. The development and evaluation of an in vitro model for assessing the impact of convective fluid flow on drug penetration through avascular cancer tissues.
… (IFP) in tumours is recognized as a barrier to drug delivery resulting in reduced efficacy. High IFP impedes the normal process of convective fluid flow (CFF) from blood vessels into the interstitium. The aim of this study was to develop an in vitro model that could be used to measure CFF and to …
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Nuclear Factor Kappa B Pathway and human cancer therapeutics
Cancer is one of the major causes of morbidity in the world. Although the overall survival of cancer has been significantly improved by chemotherapy in the last three decades, the success of cancer chemotherapy is still severely limited by the lack of selectivity of anti-cancer drugs to malignant …
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Biomimetic and vascularized 3-d liver cancer model
Anti-angiogenic drugs have failed to show significant extended mortality, except when co-administered with chemotherapy drugs in clinical trials. This should be predicted by in vitro models, and yet 2D in vitro models of liver cancer co-administered with these two types of drugs show increased cell …
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Studies on the anti-cancer potential of sesquiterpene lactone parthenolide
… This compound has long been known to have potent anti-inflammatory properties. However, its anti-cancer properties are less studied. Thus, the main objective of this study is to systematically investigate the anti-cancer properties of parthenolide in vitro and in vivo. The results from current …
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An ensemble based approach for drug sensitivity prediction
Drug sensitivity prediction based on genomic characterization remains a significant challenge in the area of systems medicine. Multiple approaches have been proposed for mapping genomic characterization to drug sensitivity and among them ensemble based learning techniques such as random forests …
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Selective therapy with minor groove binders
… of Strathclyde has developed extremely potent anti-bacterial molecules known as minor groove binding agents (MGB) which intrinsic helicity allows binding to the minor groove of DNA. These molecules were effective in vivo, non-toxic and showed activity and selectivity against Gram positive …
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Ameliorating the toxic side-effects of cisplatin by systematically modulating its metabolism in human plasma with chemoprotective agents
… investigated on the metabolism of the Pt-based anti-cancer drug cis-platin (CP) in human blood plasma in vitro. All three sulfur compounds resulted in the formation of Pt-S complexes independent of their order of addition to plasma while concomitantly reducing the plasma protein binding of …
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Design of Functional Polymeric Micelles as a Carrier for Anticancer Drug Delivery
… nanoparticles are frequently utilized as drug delivery carriers due to their particular core/shell structure, ease of functionalization, sustained circulation in the blood and its ability to passively accumulate in leaky tumor tissues. Two important factors that should be considered in the …
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GENERATION AND ANALYSES OF krasV12 TRANSGENIC ZEBRAFISH TO STUDY INTESTINE TUMORIGENESIS
Mutations in KRAS contribute to 40% of colorectal cancer cases. To explore the mechanism of krasV12 oncogene in intestine cancer we generated a novel inducible model in zebrafish. The stable transgenic zebrafish expressed krasV12 under a gut specific promoter and the EGFPkrasV12 enabled live …
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