Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"anti-angiogenic therapy"”.
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Targeting Metabolic Adaptations to Anti-Angiogenic Therapy In Ovarian Cancer
… Despite modest clinical improvements with anti-VEGF antibody (AVA) therapy, adaptive resistance is nearly ubiquitous and additional therapeutic options are limited. A dependence on glutamine metabolism, <em>via </em>the enzyme glutaminase (GLS), is a known mechanism of adaptive …
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Dynamics of vascular normalization during anti-angiogenic therapy : implications for combination therapy
… blood vessels for growth, and the goal of anti-angiogenic therapy is to destroy the tumor vasculature. Recent findings suggest that anti-angiogenic therapy enhances radiation and chemotherapy responses. These findings seem paradoxical, since anti-angiogenic therapy prunes tumor vasculature …
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Isolation of Therapeutic Antibodies Against Microseminoprotien to Potentially Overcome Resistance to Anti-Angiogenic Therapy
… tumors. To combat the formation of tumors, an anti-VEGF drug, bevacizumab, is used to starve tumors of blood that provide essential nutrients. While platinum-taxane doublet therapy in addition to cytoreductive surgery has been the gold standard treatment for patients with ovarian cancer, …
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Exploring vasculogenic mimicry and anti-angiogenic therapy resistance within breast cancer patient-derived tissue xenograft models
… targeting tumour neovascularisation with anti-angiogenic therapy (AAT) holds much promise to halt tumour growth and inhibit metastasis, however AAT trials have not delivered the predicted clinical success in a large amount of the cancer types tested, including breast cancer. It has become …
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Anti-Angiogenic Therapy in Non-Small Cell Lung Cancer: Characterizing a New Therapy and Investigating Potential Mechanisms of Resistance
… Genentech/Roche), a humanized monoclonal antibody that recognizes human VEGF and blocks VEGF from binding to VEGF receptor (VEGFR) 1 and 2, was the first anti-angiogenic drug approved by the United States Food and Drug Administration for the treatment of cancer and remains the gold …
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Hypoxia Activated Prodrug and Anti-Angiogenic Therapy Cooperate to Treat Pancreatic Cancer But Elicit Immune Suppressive G-Mdsc Infiltration
… of the tumor vasculature to hypoxia reduction therapy, as well as the downstream consequences of hypoxia reduction on the cellular composition of the tumor microenvironment and the responsiveness to immunotherapy. Here, we used a Kras+/G12DTP53+/R172HPdx1-Cre (KPC) derived model of pancreatic …
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Elucidating how αvβ3-integrin regulates neuropilin-1’s role in tumour angiogenesis in order to improve anti-angiogenic therapy
… However, its initial promise as a target in anti-angiogenic therapy has wavered since the αvβ3-integrin antagonist cilengitide did not meet its end point in Phase III clinical trials for the treatment of glioblastoma. This failure corresponds with the enhanced tumour growth and angiogenesis …
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A novel nanodelivery system for combination tumor therapy
Anti-angiogenic therapy offers many benefits over traditional cytotoxic chemotherapy including fewer toxic side effects and the reduced development of drug resistance. Anti-angiogenics alone have not proven effective in inducing tumor regression in the clinic due to both the cytostatic nature of …
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Platelets and Anti-Angiogenic Resistance In Ovarian Carcinoma
<p>Background: Resistance to targeted anti-angiogenic therapy is a growing clinical concern given the disappointing clinical impact of anti-angiogenic. Platelets represent a component of the tumor microenvironment that are implicated in metastasis and represent a significant reservoir of angiogenic …
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MOLECULAR ASPECTS OF ENDOTHELIAL CELL FUNCTION AND HYPOXIA-DEPENDENT TUMOR ANGIOGENESIS
… importance, and has led to the development of anti-angiogenic therapy in the treatment of cancer patients. Anti-angiogenic drugs targeting the vascular endothelial growth factor (VEGF) pathway may prolong progression-free survival and overall survival in some patients. However, the results are …
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Culture of dimethylhydrazine induced murine angiosarcoma and an evaluation of anti-angiogenic therapy of primary tumor and of tumor metastasisLa mise en culture d'angiosarcomes murins induits par le diméthylhydrazine et l'évaluation du traitement anti-angiogénique de tumeurs primaires et métastasiques
… La seconde partie se rapporte à la thérapie anti-angiogénique des tumeurs primaires et métastasiques. Partie 1: Cancérogénèse induite par le DMH et culture de cellules endothéliales d'origine tumorale. La recherche sur le traitement et l'étiologie du sarcome de Kaposi associé au SIDA (SK …
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Targeted Inhibition of Sp1 Transcription Factor and Anti-Angiogenesis of Human Pancreatic Cancer
… role of Sp1 in angiogenesis, the impact of anti-angiogenic therapy on the Sp1/ VEGF signaling and the Sp1 signaling alteration on the anti-angiogenic therapy effect are unclear. The understanding of Sp1 regulation on VEGF and their interactions has significant clinical implications. Sp1 and …
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Dynamic Digital Optical Tomography for Cancer Imaging and Therapy Monitoring
… study monitoring early tumor response to anti-angiogenic therapy; and a clinical study monitoring individual patient response to neoadjuvant chemotherapy. These studies show that diffuse optical tomography is a valuable imaging modality that can play an important role in cancer detection …
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A novel in vivo tumor oxygen profiling assay: Combining functional and molecular imaging with multivariate mathematical modeling
… a novel high spatio-temporal in vivo assay to quantify tumor oxygenation and hypoxia. The assay implements a biophysical model of oxygen transport to fuse parameters acquired from in vivo functional and molecular imaging modalities. ^ Introduction: Tumor hypoxia plays an important role in …
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Elucidating the role of endothelial αvβ3-integrin in tumour growth and angiogenesis
… αvβ3-integrin seemingly poses an ideal anti-angiogenic target. Its expression is vastly up-regulated in neo-angiogenic vessels, while its expression in quiescent vasculature is minimal. However, anti-angiogenic therapy targeting αvβ3-integrin has proven somewhat disappointing. In part, …
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On the Role of Polyamines and Microvesicles in Tumour Development. Regulation by Hypoxia and Implications for Therapeutic Intervention of Cancer.
… heparan sulphate proteoglycans (HSPGs) by anti-HS antibodies inhibits the bioavailability of exogenous polyamines, and that combined targeting of polyamine biosynthesis by α-difluoromethylornithine (DFMO) and HSPG-dependent uptake by a HIV-1 trans-activator of transcription (TAT) peptide, …
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Mechanistic Studies On the Role of Polyamines and Microvesicles in Tumor Growth and Hypoxia-mediated Angiogenesis
… into the hallmarks of cancer. Accordingly, anti-angiogenic therapy was developed for the treatment of cancer patients; however, clinical studies have shown benefit only for a small group of patients, thus challenging the preceding expectations on anti-angiogenic targeting of tumors and …
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Targeting Vasculogenic Mimicry in Cancer
… angiogenesis an attractive target for cancer therapy, but disappointingly, anti-angiogenic drugs often times show limited efficacy in the context of cancer, with benefits only being transient followed by relapse and resistance. In retrospect, this is not surprising because it is now …
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Ionizing Radiation and Endostatin Gene Therapy Against Lung Tumor
<p>Although many advances have been made in radiotherapy, tumor radioresistance and normal tissue damage continue to always be important issues for radiation oncologists. Numerous reports have also documented that radiation exposure increases the risk for malignancy and suppresses immune …