Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"anti-angiogenic therapies"”.
-
Effects of Combined Bevacizumab and Paclitaxel On Tumor Interstitial Fluid Pressure In A Preclinical Breast Cancer Model
… attention, is the inefficient transport of anticancer drugs into tumor tissue. These impaired transports of chemotherapy into the tumor have been attributed to abnormal microvasculature and to pathologically increased tumor hypertension also called: interstitial fluid pressure (IFP). The …
-
Peptide inhibitors of angiogenesis in endometriosis and the female reproductive system
… The inhibition of blood vessel growth by anti-angiogenic agents is a potential strategy to manage endometriosis disease progression. This thesis investigated angiogenesis of endometriosis lesions, and evaluated a novel anti-angiogenic peptide as a potential therapeutic to manage …
-
Anti-VEGF Therapy Modulates Immune Cell Infiltration and Function in Multiple Breast Cancer Models
… target for tumor therapy. Many of the current anti-angiogenic therapies target vascular endothelial growth factor-A (VEGF). VEGF binds to and activates two primary VEGF receptors, VEGFR1 and VEGFR2. VEGFR2 is the primary angiogenic receptor, while the function of VEGFR1 is less defined. It is …
-
The development of novel metabolic therapies for the treatment of glioblastoma
… there is a desperate need for effective new therapies capable of selectively targeting this tumour. One potential solution is to exploit abnormal metabolic process unique to glioblastoma cells, which play a key role in promoting their rapid unregulated growth and survival. This led to the …
-
Differential Angiogenic Capability and Hypoxia Responses in Glioma Stem Cells
… We measured the expression of a panel of angiogenic factors secreted by GSCs. In comparison with matched non-GSC populations, GSCs consistently secreted markedly elevated levels of vascular endothelial growth factor (VEGF), which were further induced by hypoxia. In an in vitro model of …
-
Development and application of an imaging and spatially-driven toolkit to elucidate vasculogenic mimicry in breast cancer mouse models
… been shown to underpin therapeutic resistance to anti-angiogenic therapies (AATs). Although molecular data largely supported by in vitro work has immensely contributed to our understanding of VM, the spatial features that define the VM phenotype remain largely unknown and understudied. How these …