Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"anti-angiogenic drugs"”.
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A dendrimer-based prodrug for use in an anti-cancer nanocell
… present a recent concept in cancer therapy: an anti-cancer nanocell that is capable of the spatial and temporal targeting of drugs to tumor cells. The combination of targeting mechanisms designed into the nanocell is a product of our current understanding of tumors. The design serves to improve …
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An investigation into the mechanisms of angiogenesis and breast cancer metastasis
… therapy resistance by secreting different pro-angiogenic growth factors that allow them to overcome the effect of anti-angiogenic drugs. Thus, characterising the mechanisms that promote tumour angiogenesis may help to stop the development of tumour metastasis. Here it was determined that ATF2 …
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Biomimetic and vascularized 3-d liver cancer model
Anti-angiogenic drugs have failed to show significant extended mortality, except when co-administered with chemotherapy drugs in clinical trials. This should be predicted by in vitro models, and yet 2D in vitro models of liver cancer co-administered with these two types of drugs show increased cell …
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Mutational Analysis of the Export Targeting Motif of Fibroblast Growth Factor 2, a Mediator of Tumor-Induced Angiogenesis
… the way for the development of a novel class of anti-angiogenic drugs. In this thesis, a robust model system designed to quantitatively assess FGF2 secretion under various experimental conditions was developed. A retroviral expression system was established in CHO cells that allows for a stable …
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Targeting Vasculogenic Mimicry in Cancer
… target for cancer therapy, but disappointingly, anti-angiogenic drugs often times show limited efficacy in the context of cancer, with benefits only being transient followed by relapse and resistance. In retrospect, this is not surprising because it is now well-appreciated that some aggressive …
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MOLECULAR ASPECTS OF ENDOTHELIAL CELL FUNCTION AND HYPOXIA-DEPENDENT TUMOR ANGIOGENESIS
… importance, and has led to the development of anti-angiogenic therapy in the treatment of cancer patients. Anti-angiogenic drugs targeting the vascular endothelial growth factor (VEGF) pathway may prolong progression-free survival and overall survival in some patients. However, the results are …
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Anti-Angiogenic Therapy in Non-Small Cell Lung Cancer: Characterizing a New Therapy and Investigating Potential Mechanisms of Resistance
… One of the first targets for this new class of drugs was vascular endothelial growth factor (VEGF) a predominant mediator of physiological and pathological angiogenesis. Bevacizumab (Avastin®, Genentech/Roche), a humanized monoclonal antibody that recognizes human VEGF and blocks VEGF from …
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Quantification Of Vascular Parametric Indices Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging
… activity in early clinical trials of novel drugs targeting the tumor vasculature using gadolinium-DTPA (Gd) as a contrast agent. However, it has some limitations, such as reproducibility, data acquisition times, the presence of noise, extracting contrast concentration, estimating T1 …