Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 106 for “"anti-angiogenic"”.
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Platelets and Anti-Angiogenic Resistance In Ovarian Carcinoma
<p>Background: Resistance to targeted anti-angiogenic therapy is a growing clinical concern given the disappointing clinical impact of anti-angiogenic. Platelets represent a component of the tumor microenvironment that are implicated in metastasis and represent a significant reservoir of angiogenic …
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Targeting Metabolic Adaptations to Anti-Angiogenic Therapy In Ovarian Cancer
… Despite modest clinical improvements with anti-VEGF antibody (AVA) therapy, adaptive resistance is nearly ubiquitous and additional therapeutic options are limited. A dependence on glutamine metabolism, <em>via </em>the enzyme glutaminase (GLS), is a known mechanism of adaptive …
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Dynamics of vascular normalization during anti-angiogenic therapy : implications for combination therapy
… blood vessels for growth, and the goal of anti-angiogenic therapy is to destroy the tumor vasculature. Recent findings suggest that anti-angiogenic therapy enhances radiation and chemotherapy responses. These findings seem paradoxical, since anti-angiogenic therapy prunes tumor vasculature …
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Characterizing the anti-angiogenic resistance potential of cross-family PDGF:VEGFR2 interactions in glioblastoma
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-05-01
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Isolation of Therapeutic Antibodies Against Microseminoprotien to Potentially Overcome Resistance to Anti-Angiogenic Therapy
… tumors. To combat the formation of tumors, an anti-VEGF drug, bevacizumab, is used to starve tumors of blood that provide essential nutrients. While platinum-taxane doublet therapy in addition to cytoreductive surgery has been the gold standard treatment for patients with ovarian cancer, …
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Exploring vasculogenic mimicry and anti-angiogenic therapy resistance within breast cancer patient-derived tissue xenograft models
… targeting tumour neovascularisation with anti-angiogenic therapy (AAT) holds much promise to halt tumour growth and inhibit metastasis, however AAT trials have not delivered the predicted clinical success in a large amount of the cancer types tested, including breast cancer. It has become …
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Anti-Angiogenic Therapy in Non-Small Cell Lung Cancer: Characterizing a New Therapy and Investigating Potential Mechanisms of Resistance
… Genentech/Roche), a humanized monoclonal antibody that recognizes human VEGF and blocks VEGF from binding to VEGF receptor (VEGFR) 1 and 2, was the first anti-angiogenic drug approved by the United States Food and Drug Administration for the treatment of cancer and remains the gold …
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Hypoxia Activated Prodrug and Anti-Angiogenic Therapy Cooperate to Treat Pancreatic Cancer But Elicit Immune Suppressive G-Mdsc Infiltration
… with both a hypoxia-activated prodrug and anti-angiogenic therapy, and that these immunosuppressive myeloid cells act in a setting of persistent hypoxia to maintain adaptive immune resistance.</p>
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Elucidating how αvβ3-integrin regulates neuropilin-1’s role in tumour angiogenesis in order to improve anti-angiogenic therapy
… However, its initial promise as a target in anti-angiogenic therapy has wavered since the αvβ3-integrin antagonist cilengitide did not meet its end point in Phase III clinical trials for the treatment of glioblastoma. This failure corresponds with the enhanced tumour growth and angiogenesis …
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Inhibition of progestin-induced VEGF in mammary cancer by curcumin and 2-methoxy estradiol and their potential role as anti-angiogenic & chemopreventive compounds
… endothelial growth factor (VEGF), a potent angiogenic growth factor. In the present study I show that curcumin, a turmeric root derivative, and 2-methoxyestradiol (2ME2), a natural metabolite of estradiol, effectively inhibit progestin-induced VEGF secretion from breast cancer cells in …
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A novel nanodelivery system for combination tumor therapy
Anti-angiogenic therapy offers many benefits over traditional cytotoxic chemotherapy including fewer toxic side effects and the reduced development of drug resistance. Anti-angiogenics alone have not proven effective in inducing tumor regression in the clinic due to both the cytostatic nature of …
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MOLECULAR ASPECTS OF ENDOTHELIAL CELL FUNCTION AND HYPOXIA-DEPENDENT TUMOR ANGIOGENESIS
… importance, and has led to the development of anti-angiogenic therapy in the treatment of cancer patients. Anti-angiogenic drugs targeting the vascular endothelial growth factor (VEGF) pathway may prolong progression-free survival and overall survival in some patients. However, the results are …
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Mechanistic Studies On the Role of Polyamines and Microvesicles in Tumor Growth and Hypoxia-mediated Angiogenesis
… into the hallmarks of cancer. Accordingly, anti-angiogenic therapy was developed for the treatment of cancer patients; however, clinical studies have shown benefit only for a small group of patients, thus challenging the preceding expectations on anti-angiogenic targeting of tumors and …
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A novel in vivo tumor oxygen profiling assay: Combining functional and molecular imaging with multivariate mathematical modeling
… a novel high spatio-temporal in vivo assay to quantify tumor oxygenation and hypoxia. The assay implements a biophysical model of oxygen transport to fuse parameters acquired from in vivo functional and molecular imaging modalities. ^ Introduction: Tumor hypoxia plays an important role in …
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Peptide inhibitors of angiogenesis in endometriosis and the female reproductive system
… The inhibition of blood vessel growth by anti-angiogenic agents is a potential strategy to manage endometriosis disease progression. This thesis investigated angiogenesis of endometriosis lesions, and evaluated a novel anti-angiogenic peptide as a potential therapeutic to manage …
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Novel anti-endothelial therapeutic strategies in malignant melanoma : the metronomic approach.
… schedule resulting in an overall ‘non specific’ anti-angiogenic effect. It is now being studied in clinical trials alone and in combination with specific antiangiogenic agents.This thesis had two main aims: firstly to investigate the additive or synergistic antiendothelial effects of a number of …
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RGD-targeted Solid Lipid Nanoparticles Containing Asiatic Acid for the Treatment of Cancer
Selective anti-cancer treatment and targeting is needed to help minimise unwanted side-effects from conventional chemotherapy. Advanced drug delivery systems (DDSs) that have the potential for passive and active targeting have been of significant interests in the past decades, particularly with the …
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Elucidating the role of endothelial αvβ3-integrin in tumour growth and angiogenesis
… αvβ3-integrin seemingly poses an ideal anti-angiogenic target. Its expression is vastly up-regulated in neo-angiogenic vessels, while its expression in quiescent vasculature is minimal. However, anti-angiogenic therapy targeting αvβ3-integrin has proven somewhat disappointing. In part, …
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Culture of dimethylhydrazine induced murine angiosarcoma and an evaluation of anti-angiogenic therapy of primary tumor and of tumor metastasisLa mise en culture d'angiosarcomes murins induits par le diméthylhydrazine et l'évaluation du traitement anti-angiogénique de tumeurs primaires et métastasiques
… La seconde partie se rapporte à la thérapie anti-angiogénique des tumeurs primaires et métastasiques. Partie 1: Cancérogénèse induite par le DMH et culture de cellules endothéliales d'origine tumorale. La recherche sur le traitement et l'étiologie du sarcome de Kaposi associé au SIDA (SK …
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