Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"anti-angiogenesis"”.
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Targeted Inhibition of Sp1 Transcription Factor and Anti-Angiogenesis of Human Pancreatic Cancer
… adenocarcinoma. The definitive role of Sp1 in angiogenesis, the impact of anti-angiogenic therapy on the Sp1/ VEGF signaling and the Sp1 signaling alteration on the anti-angiogenic therapy effect are unclear. The understanding of Sp1 regulation on VEGF and their interactions has significant …
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A novel nanoscale delivery system for spatio-temporal delivery of combination chemotherapy
… the combination of traditional chemotherapy with anti-angiogenesis agents that inhibit blood vessel growth. However, the implementation of this strategy has faced two major obstacles. First, the long-term shutdown of tumor blood vessels by the anti-angiogenesis agent can prevent the tumor from …
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Purinergic angiogenesis : an investigation of the role of extracellular nucleotide mediated signaling in angiogenesis
Angiogenesis refers to the growth and maturation of new vessels from pre-existing differentiated blood vessels. Co-ordination of angiogenic responses is crucial for a wide range of physiological and pathological processes. In particular, angiogenesis is hypothesized to facilitate tumour growth and …
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Regulation of Blood Vessel Development via Rho Family GTPase Signaling
… the Rho GTPase Cdc42 during vasculogenesis and angiogenesis. We find that Cdc42 is essential for organization of EC adhesion, as its loss results in disorganized cell-cell junctions and reduced focal adhesions. Endothelial polarity is also rapidly lost upon Cdc42 deletion, as seen by failed …
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Blood Vessel Development
… on the function of Rasip1 in vasculogenesis, angiogenesis and vessel maintenance in developing embryo and in adults. An observation of transient Rasip1 localization at apical membranes in endothelial cells during in vitro tube formation provided an insight where Rasip1 possibly functions. Mice …
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Role of The Ang-Tie2 Pathway In The Invasive Recurrence of Gbm Following Anti-Vegf Therapy
… of bevacizumab, a humanized monoclonal anti-VEGF antibody, for the treatment of gliomas led to its accelerated approval for the treatment of patients with recurrent glioma. However, despite strong anti-tumor effects, upon treatment with bevacizumab, patients will invariably recur with a …
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Chitosan/Ellagic Acid Composite Materials for Local Cancer Therapy
… and indirect cell culture using MTS assay. Anti-cancer mechanism of the composite films against cancer cells was investigated using apoptosis assay, caspase-3 activation, western blot for p53, and anti-angiogenesis assays. In the <em>in vivo </em>study, an animal subcutaneous model was used …
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First-order statistical speckle models improve robustness and reproducibility of contrast-enhanced ultrasound perfusion estimates
Contrast-enhanced ultrasound (CEUS) permits the quantification and monitoring of adaptive tumor responses in the face of anti-angiogenic treatment, with the goal of informing targeted therapy. However, conventional CEUS image analysis relies on mean signal intensity as an estimate of tracer …
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Einfluß von PTK787/ZK222 584, einem spezifischen Rezeptor-Tyrosinkinase-Inhibitor, auf Anatomie, Dichte, Permeabilität und Blutfluß in Tumorgefäßen im murinen Nierenzellkarzinom
… dynamische MRT im bekannten Renca-Modell unter anti-angiogener Therapie zu evaluieren um ein mögliches Diagnostikum für die Kontrolle einer anti-angiogenen Therapie in der Klinik zu erhalten.Zur Evaluation der MRT-Diagnostik wurden die Dopplersonographie, Immunhistologie und Fluoreszenzfärbung …