Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"anti-androgen"”.
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Targeting anti-androgen resistance in prostate cancer using preclinical models with physiological nutrient levels
Prostate cancer is driven by upregulated androgen receptor signalling that regulates cellular growth and metabolism. While anti-androgen therapies such as Enzalutamide can be effective against prostate cancer, 60% of patients will develop Enzalutamide resistance which is currently incurable. Since …
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p,p' DDE Regulated Gene Expression and Possible Mechanisms of Action in Breast Tumor
… developmental exposure to the reported anti-androgen p,p' DDE accelerated mammary tumor development. This study tested the potential cancer-promoting actions of p,p' DDE, the most prevalent and persistent DDT metabolite. </p><p> Objectives: To identify and characterize the expression of …
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Development of a novel, clinically-relevant model for investigating factors that stimulate human hair growth
… increased only intermediate follicle growth; the anti-androgen, cyproterone acetate (1¿M), prevented this stimulation, unlike the 5¿-reductase type 2 inhibitor finasteride (40ng/ml). Immunohistochemistry demonstrated androgen receptor and 5¿-reductase type 2 proteins in both follicle types, while …
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Sex Determination And Differentiation In The Common Snapping Turtle - A Reptile With Temperature-Dependent Sex Determination
… is well established that sex steroid hormones, androgens and estrogens, are important for sex determination and differentiation in TSD species. Yet, the role of androgens in these processes is not well understood. This dissertation addresses these questions in two parts. First, to identify …
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Assessing Brook Stickleback (Culaea inconstans) as a bioindicator for endocrine disrupting compounds in aquatic environments
… fish, particularly for assessing EDCs with (anti-)androgenic activity. Male sticklebacks build nests using spiggin, an androgen-responsive glycoprotein, which can be used to assess (anti-)androgenic exposure. EDC assessment in the field using threespine stickleback and the spiggin biomarker …
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Risk stratification in the management of localised prostate cancer treated with radical radiotherapy
… multiple strategies), systemic approaches using androgen deprivation and up-front chemotherapy in addition to adjuvant androgen deprivation therapies and radiotherapy in the post-prostatectomy setting. In contrast to other tumour sites, however, commonly employed methods of risk stratification …
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The role of beta-catenin in the development of fetal ovary and female germ cells
… testis-specific coelomic vessel, appearance of androgen-producing adrenal-like cells, and the loss of female germ cells. The observed phenotypes were similar to those found in the R-spondin1 (Rspo1) and Wnt4 knockout (KO) ovaries, indicating that these three factors were in the same pathway to …
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Investigating persistent organic pollutants as endocrine disruptors of androgen receptor signalling
… perfluoroalkyl acids (PFAAs) for disrupting androgen receptor (AR) signalling. <br/><br/>The Total POP mixture using in this project consisted of a combination of 29 chemicals modelled on the exposure profile of a Scandinavian population and 6 sub-mixtures: brominated (Br) chlorinated (Cl), …