Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 32 for “"anti-TNF"”.
-
Optimizing immunomodulator and anti-TNF treatment in Inflammatory Bowel Diseases.
Contains fulltext : 297656.pdf (Publisher’s version ) (Open Access)
-
Personalized medicine in rheumatoid arthritis: Pharmacogenetics of anti-TNF and beyond.
Contains fulltext : 129676.pdf (Publisher’s version ) (Open Access)
-
Progresión radiográfica en pacientes con Espondiloartritis Axial en tratamiento con anti-TNF
Contexto: La eficacia clínica de los anti-TNF en la espondiloartritis axial (EspAax) ha sido ampliamente demostrada en ensayos clínicos aleatorizados. Algunos estudios observacionales sugieren que el tratamiento a largo plazo con anti-TNF (más de 4 años) podrían ralentizar la progresión …
-
Anti-TNF treatment of chronic arthritis in clinical practice. New assessment method and predictors of efficacy and tolerability.
… biological therapies. Tumour necrosis factor (TNF) blocking therapy has been the most important biological treatment of chronic arthritis to date. The overall objective of this thesis was to develop a new assessment method of efficacy of biological therapy in clinical practice. Further …
-
Optimización del rango terapéutico de niveles de fármaco y anti-fármaco de terapia biológica anti-tnf-alfa en artritis reumatoide
… El tratamiento con fármacos biológicos anti-TNF-alfa (infliximab, adalimumab y etanercept) ha mejorado el pronóstico, pero su eficacia puede verse afectada por la formación de anticuerpos antifármaco y estar condicionada por la variabilidad en niveles de fármaco. Este estudio se centra …
-
Therapeutic drug monitoring of anti-TNF biologics in patients with Crohn's disease at Groote Schuur Hospital, Cape Town, South Africa
Monoclonal antibodies targeting Tumour Necrosis Factor-α (TNF α) have revolutionised the management of Inflammatory Bowel Disease (IBD) and have proved highly effective in both inducing and maintaining remission in both ulcerative colitis (UC) and Crohn's disease (CD). The advent of Therapeutic …
-
Therapie der Spondylitis ankylosans mit dem monoklonalen chimären anti-TNF-Antikörper Infliximab (Remicade®):Klinische Wirksamkeit und Einfluss auf die HLA-Oberflächenexpression auf Lymphozyten mit besonderer Berücksichtigung von HLA-B27
… und immunmodulatorische Effekte einer TNF-Blockade bei Patienten mit aktiver Spondylitis ankylosans untersucht. Hierzu wurde an 10 Patienten während einer 60wöchigen Infliximabtherapie eine Evaluation von Therapiewirksamkeit und -sicherheit, sowie eine durchflusszytometrische Analyse …
-
Using single-cell RNA sequencing to elucidate the biological basis of IBD and response to therapy
… no cure for IBD, biologic treatments including anti-TNF have improved the quality of life for many IBD patients. Unfortunately, many patients will fail to respond or lose response to anti-TNF treatment over time. In this thesis, single-cell RNA sequencing (scRNA-seq) was utilised to understand …
-
Análisis costo versus efectividad del Etanercept, Infliximab y Adalimumab, en pacientes con artritis reumatoide refractaria
… los antagonistas del factor de necrosis tumoral (anti-TNF), sin embargo, la eficiencia económica de este tipo de tecnologías sigue siendo un aspecto que las instituciones de salud están buscando optimizar. Objetivo: Comparar y evaluar el costo del tratamiento requerido y la efectividad de tres …
-
The Genetics of IBD: From Susceptibility to Drug Response and Patient Outcome
… I describe the results of the Personalised Anti-TNF Therapy in Crohn’s disease study. Immunogenicity to anti-TNF therapy is a major cause of loss of response, hypersensitivity reactions, and discontinuation of treatment in patients. Currently, immunogenicity cannot be predicted prior to …
-
Struttura e funzione arteriosa nelle malattie infiammatorie croniche intestinali
… che può essere normalizzata dall'uso di farmaci anti TNF-alfa.
-
Preeclampsia, Autoimmunity and The At1 Receptor
… shown that women with PE harbor specific autoantibodies: the angiotensin II type 1 receptor activating autoantibody (AT1-AA). These autoantibodies act as angiotensin II and stimulate the ubiquitous AT1 receptor. To elucidate the role of AT1-AA in the pathophysiology of PE, a model of adoptive …
-
Effects of IL-33 on the interaction between HMC-1 cells and human airway smooth muscle cells
… common form. Most cases are initiated by IgE antibodies, generally referred to as IgE-mediated allergic asthma. Treatments include β2-agonists and inhaled corticosteroids, although there is no definitive cure for the disease. Asthma results in a plethora of pathological processes, present in …
-
Measure for measure. Outcome assessment of arthritis treatment in clinical practice
… activity indices and response criteria in TNF-blockade of RA; (ii) the predictive ability of different response criteria and disease activity states regarding continuation of anti-TNF treatment of RA; (iii) Euro-QoL-5-dimensions utility development during TNF blockade of RA, PsA and SpA. …
-
The Role of Tumor Necrosis Factor (TNF) in Microglial Activation and Progressive Degeneration of Dopaminergic Neurons
… a loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). A number of studies have implicated chronic inflammation in the pathophysiology of PD; however, it is unclear which inflammatory mechanisms directly contribute to neuronal loss in PD. A number of cytokines, …
-
Genomic profiling of response to $\textit{in vivo}$ immune perturbations
… that predict clinical phenotypes such as antibody response to vaccines. It has also been recognised that both expression and phenotypic responses are traits with complex genetic architectures. This thesis examines the longitudinal transcriptomic response to immune perturbations, and its …
-
Mechanical injury and inflammatory cytokines affect cartilage integrity and tissue homeostasis : a mass spectrometric analysis of proteins with relevance to arthritis
… arthritis is evidenced by the successful use of anti-TNF-ca and anti-IL-1 therapies to abrogate disease symptoms and progression. In vitro, both IL-13 and TNF-ca promote chondrocyte-mediated matrix degradation and inhibit cartilage matrix synthesis, while mechanical damage causes cell death, …
-
Avaliação do perfil imunofenotípico e sua associação com o tratamento e a atividade de doença na artrite psoriásica
… A medicina de precisão utilizando medicamentos anti-reumáticos com base na fenotipagem de células imunes periféricas foi recentemente demonstrada para o tratamento da artrite psoriásica. O objetivo do trabalho foi avaliar o perfil imunofenotípico das células T, B, NK, NKT, monócitos e células …
-
A study of the NF-κB signalling pathway in human acute myeloid leukaemia.
… cells, appeared to be maintained by autocrine TNF production, as anti-TNF treatment impaired the observed response. These findings indicate that IκB levels underlie the high basal NF-κB activity that is observed in AML cancer cells, and possibly other types of NF-κB-dependent cancers. …
Page 1 of 2