Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"anti-TB drugs"”.
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Stereoselective synthesis 2-C-alkylglucosides, potential inhibitors of mycobacterial MshB and related enzymes
Tuberculosis (TB) is one of the world's most deadly diseases and kills approximately 1.7 million people each year. The developing resistance of TB to the two most common anti-TB drugs (isoniazid and rifampicin) proves the urgency of the current situation. The MshB reducing agent exclusively in the …
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Synthesis of Novel -1, 3, 5 - Triazine - Based - Anti-Tuberculosis Drugs.
… search of new biological entities to fight back TB and drug resistant TB is a drive behind this project. Several specific synthetic protocols have been developed using 1,3,5-triazines due to the important biological properties which they display. The chemistry and an extensive spectrum of …
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Design, synthesis and biological evaluation of verapamil analogues, reversed isoniazids and hybrid efflux pump inhibitors against Mycobacterium tuberculosis
Tuberculosis (TB) is one of the major infectious diseases and epidemics in the world. It is responsible for severe morbidity and mortality rates, especially in poor and resource-deficient countries. According to the World Health Organization 2014 report, about one third of the world's population is …
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Repurposing chlorpromazine and its metabolites for antituberculosis drug discovery
… needed to combat Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). The development of compounds that could potentiate the activity of known antimycobacterial drugs is a relatively unexplored approach to new TB drug discovery. This study aimed to generate metabolites of …
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Developing methods to prioritize in vitro drug combinations against Mycobacterium tuberculosis: fusidic acid as potential combination partner with known antitubercular agents
The tuberculosis (TB) epidemic remains a major threat to public health globally, and is exacerbated by the escalating number of multi-drug resistant cases. These factors have highlighted the urgent need for new effective therapies or different approaches to augment the efficacy of current anti-TB …
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The Consumer of Humans
… globally. Scientists have developed important drugs, such as isoniazid, rifampin, and pyrazinamide, against the disease. But these drugs must be taken for several months, are sometimes ineffective, and can cause debilitating side effects. What’s more, if people don’t finish their treatments, it …
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Construction and Use of a Transposon for Identification of Essential Genes in Mycobacteria
… threatening the ability to treat tuberculosis (TB) worldwide. The development of new anti-TB drugs requires new approaches and new drug targets. In this study, a mariner-based transposon, TnQuoVadis, was constructed to identify essential genes as potential drug targets. This transposon has an …
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Investigating permeation of anti-mycobacterial agents in Mycobacterium tuberculosis and M. tuberculosis-infected macrophages in vitro as a model for early stage tuberculosis drug discovery
Tuberculosis (TB) is the leading cause of death due to a single infectious disease and remains a major threat to global public health. The increasing emergence of multi-drug resistance to current anti-TB drugs, exacerbated by the long treatment duration, highlights the need for new effective …
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Identifying biosynthetic pathways for mycobacterial cell wall components using transposon mutagenesis
… has a distinct lipid-rich cell wall. Several anti-TB drugs target cell wall biosynthetic pathways. A good understanding of its biosynthesis will provide helpful clues for the development of novel drug targets. A strategy based on random transposon (Tn) mutagenesis with two different screening …
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Addressing challenges in the treatment of tuberculosis and tuberculosis meningitis: a pharmacometric approach
Tuberculosis (TB) is the primary cause of death from a single infectious agent worldwide. During the coronavirus disease (COVID-19) pandemic, TB briefly fell to second place, but it has now regained its position as the top infectious killer. It is caused by Mycobacterium tuberculosis and mainly …
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Semi-synthesis and evaluation of fusidic acid derivatives as potential antituberculosis agents
The causative agent of tuberculosis (TB), Mycobacterium tuberculosis (Mtb), still remains one of the most serious infectious diseases with 10 million new reported cases in 2015. Although TB is curable, the ability to acquire resistance to various antibiotics by the Mtb organism is well known. The …
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Long-term HIV and tuberculosis outcomes in co-infected patients with treatment limiting severe cutaneous adverse reactions
… amongst persons co-infected with tuberculosis (TB) and advanced HIV. The impact of SCAR on long-term HIV and TB outcomes is unknown. Methods Patients with active TB and/or HIV admitted to Groote Schuur Hospital, Cape Town, South Africa with SCAR between 1/10/2018 and 30/09/2021 were eligible. …
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Examining personal memory in film: A reflection of documenting memory-stories in Reimagining Memories
… amongst persons co-infected with tuberculosis (TB) and advanced HIV. The impact of SCAR on long-term HIV and TB outcomes is unknown. Methods Patients with active TB and/or HIV admitted to Groote Schuur Hospital, Cape Town, South Africa with SCAR between 1/10/2018 and 30/09/2021 were eligible. …
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Outcomes of patients undergoing lung resection for drug-resistant TB and the prognostic significance of pre-operative positron emission tomography/computed tomography (PET/CT) in predicting treatment failure
Background: Even with newer and repurposed anti-TB drugs almost a third of patients with XDR-TB have unfavourable outcomes. In patients with localised disease and adequate pulmonary reserve, surgery is an important adjunctive treatment. However, there are no outcome data from TB endemic countries, …
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Evaluation of anti-tuberculosis potentials of selected medicinal plants in Endau Rompin, Johor, Malaysia
Tuberculosis (TB) remains an escalating health crisis globally which prompts new approaches to find more effective therapeutic strategies. Medicinal plants of Malaysia have a significant role to play in being able to provide new therapeutic remedies. The local people of Kampung Peta (Jakun tribe), …
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Prevalence of drug-resistant tuberculosis and associated risk factors among patients in the Northern Region of South Africa
Background: Drug-resistant TB is a major global health threat, driving the ongoing TB epidemic and increasing morbidity and mortality worldwide. Currently, national tuberculosis (TB) control programmes are challenged by the emergence of drug resistance to more anti-TB drugs resulting in multi-drug …
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Population pharmacokinetic and pharmacodynamic modelling to improve tuberculosis treatment
… little is known about the effect of pregnancy on anti-TB drugs concentrations. A critical challenge to the global efforts to control the tuberculosis epidemic is the spreading of drug resistance to first-line tuberculosis drugs. The treatment of drug-resistant tuberculosis relies on both new …
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Prevalence of Multidrug-Resistant Tuberculosis in Adults at University Teaching Hospital
Tuberculosis (TB) is an infectious disease caused by There were 14.4 million individuals worldwide living with TB including half a million cases of Multidrug-resistant (MDR) TB in 2006. A most serious aspect of the problem has been the emergence of MDR-TB and extensively drug-resistant (XDR) …
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Prevalence of Multidrug-Resistant Tuberculosis in Adults at University Teaching Hospital
Tuberculosis (TB) is an infectious disease caused by There were 14.4 million individuals worldwide living with TB including half a million cases of Multidrug-resistant (MDR) TB in 2006. A most serious aspect of the problem has been the emergence of MDR-TB and extensively drug-resistant (XDR) …
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Acceptability of Oral Immunization Against Cholera and Typhod Fever among School Children in Lusaka
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. There were 14.4 million individuals worldwide living with TB including half a million cases of Multidrug-resistant (MDR) TB in 2006. A most serious aspect of the problem has been the emergence of MDR-TB and extensively …
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