Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 107 for “"anti-HIV"”.
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Development of a Modular Anti-HIV Transducer Protein
The combination antiretroviral therapy (cART) suppresses Human Immunodeficiency Virus (HIV) infection and allows restored long-term health in people living with the HIV. Current treatment provided infection management but not a complete cure. In the absence of treatment, virus level rebound due to …
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Design and Construction of an Anti-HIV Protease Transducer
Current therapies against HIV, mainly the highly active anti-retroviral therapy (HAART), concentrate on reducing the viral load and recovering CD4 levels, however they are faced with a rebound of HIV levels on cessation of therapy. Also of concern is the number of reports on resistance to such …
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Expression of anti-HIV peptides in tobacco cell culture systems
Submitted in fulfilment of the requirements for the Degree of Master of Technology: Biotechnology, Durban University of Technology, Durban, South Africa, 2009.
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Development of Catalytic RNAs as Potential Anti-HIV-1 Agents
… activity (ribozymes) targeted to the genome of HIV-1 were developed and demonstrated to mediate site-specific cleavage of the HIV-1 RNA in vitro and to inhibit viral proliferation intracellularly. Two classes of ribozymes that incorporate a "hammerhead" catalytic center were utilized, eotide …
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In vitro selection and characterisation of human anti-HIV-1 antibody fragments
Generation of neutralising antibodies with broad specificity would be one of the effective approaches to control HIV-1 spread. It is clear that a method that allows rapid generation of neutralising antibodies is needed. This project aims at developing a novel approach to rapidly access human …
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Therapeutic Uses of Broadly Neutralizing Anti-HIV-1 Antibodies in Humanized Mice
<p>Combination anti-retroviral drug therapy (ART) significantly suppresses HIV-1 viremia in most infected individuals, but is incapable of curing disease. The major barrier to HIV-1 cure is a population of long-lived cells that harbor replication-competent provirus and are refractory to current …
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Enhancement of anti-HIV-1 Ribozyme Activities by Rev Binding and Multimerization
… target. Human immunodeficiency virus type1 (HIV- 1) infectivity is dependent on <em>env</em> gene expression. HIV-1 Rev protein binds to a higher ordered RNA structure within the <em>env</em> transcript termed the Rev Binding Element (RBE). In anti-HIV gene therapy employing ribozymes to …
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Herstellung und Charakterisierung eines anti-HIV-Inhibitors basierend auf modifiziertem Serum Albumin
… (molares Verhältnis HSA zu HOCl 1:1000) an das HIV-1 gp120 bindet, wurde es VEBP (Virus Envelope Bindendes Protein) genannt. In einem Synzytien-Test wurde die Wirksamkeit des VEBP gegen HIV-1 überprüft. Zellen, die CD4, CXCR4 und CCR5 exprimieren, wurden mit einem gp160-Expressionsvektor …
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Targeted expression of the anti-HIV microbicide lectin griffithsin in maize and tobacco
… Protein based microbicides,-namely, neutralising antibodies and peptide lectins- lend themselves to production in plants (De Muynck et al., 2010; Matoba et al., 2010; Sexton et al. 2006; O’Keefe et al., 2009). One of these lectins, namely Griffithsin (GRFT) was isolated from the blue green algae …
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Cytotoxic, anti-inflammatory, antibacterial and anti-HIV effects of tabernaemontana elegans leaves and fractions
… properties. There have been no reports about the antimicrobial activity of the plant on selected opportunistic bacteria nor any reported anti-HIV and anti-inflammatory effects of T. elegans leaf fractions as far as literature is concerned. Objective: The aim of the study was to determine the …
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Investigate the effect of Bacterial Vaginosis-associated bacteria on the efficacy of Anti-HIV therapy
… with human immunodeficiency virus type 1 (HIV-1) remains one of the leading causes of death worldwide with young women in sub-Saharan Africa the most affected. Although pre-exposure prophylaxis (PrEP) with antiretroviral (ARV) drugs such as tenofovir (TFV) and emtricitabine have been shown …
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Investigate the effect of Bacterial Vaginosis-associated bacteria on the efficacy of Anti-HIV therapy
… with human immunodeficiency virus type 1 (HIV-1) remains one of the leading causes of death worldwide with young women in sub-Saharan Africa the most affected. Although pre-exposure prophylaxis (PrEP) with antiretroviral (ARV) drugs such as tenofovir (TFV) and emtricitabine have been shown …
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Synthesis and anti-HIV activity of [d4U]-spacer-[HI-236] bifinctional HIV-1 reverse transcriptase inhibitors
This thesis describes the design and synthesis of bifunctional drugs combining anucleoside (d4U) and non-nucleoside (HI-236) reverse transcriptase inhibitor linkedvia different spacers between C-5 of the NRTI and 0-1 of the NNRTI. Three targets were successfully synthesized in a divergent manner …
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Keteneylidenetriphenylphosphorane as a Versatile C-2 Building Block Leading to Tetronic Acids with Potential Herbicidal and anti-HIV Activity
… derivatives have been found to be important HIV-1 protease inhibitors. This work is concerned with using keteneylidenetriphenylphosphorane as a new route to highly functionalised HIV-protease inhibitors. New synthetic techniques such as microwave irradiation is investigated as a means to …
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Assessing anti-HIV/AIDS campaigns in Zambia: a case study of strategies and tactics used by the Commonwealth Youth Programme in Lusaka
… had been and was doing to solve some of the HIV/AIDS problems of the youth in Zambia; to find out what HIV/AIDS strategies and tactics had been/or were being employed by the Commonwealth Youth Programme (CYP) to try to combat HIV/AIDS and try to analyse the anti-HIV/AIDS strategies and …
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Solution-phase and automated solid-phase synthesis of high-mannose oligosaccharides : application to carbohydrate microarrays and biological studies
… 2G12, cyanovirin-N, and a recently identified anti-HIV protein, scytovirin.
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HIV neutralization through use of antibodies and pharmacokinetics of topical applications
The Human Immunodeficiency Virus Type 1 (HIV-1), a sexually transmitted retrovirus that causes the Acquired Immunodeficiency Syndrome (AIDS), infects over two million people a year. Several methods introduced to prevent HIV-1 transmission, such as condoms, circumcision and antiretroviral drugs, …
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Macrocyclic Polyamines and Their Metal Complexes Targeting HIV-1
M40401 is a well known antioxidant and as of late, it has been studied for anti- HIV properties. It was reported to reduce apoptosis of astrocytes caused by HIV- 1 infected macrophages (M/M) supernatants, and in 2005, a poster presented at the International Conference for Antiviral Research claimed …
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Synthesis and Antiviral Evaluation of Some 3'-Carboxymethyl-3'-deoxyadenosine Derivatives
… developed. Target compounds were evaluated for anti-HIV and anti-HIV integrase activities, but were not active at the concentrations tested.
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