Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"anti-CD40"”.
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Engineered Anti-CD40 Agonist Antibody for Cancer Vaccine Delivery
Cancer vaccines targeting patient-derived neoantigens offer great promise for personalized cancer therapy but face challenges in achieving targeted delivery to antigen-presenting cells (APCs) to elicit robust and durable cancer-specific immune responses. We synthesized an anti-mouse CD40 …
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Liposome-anchored local delivery of immunomodulatory agents for tumor therapy
… present in advanced tumors. Agonistic antibodies against the co-stimulatory receptors CD40 and CD137, Toll-Like Receptor (TLR) ligands such as CpG oligonucleotides, and immunostimulatory cytokines such as IL-2 have all previously demonstrated potent, synergistic anti-tumor effects. …
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The role of human CD23 in lgE homeostasis & allergic disease
… of human B cells, in a similar way to C3d-antigen complexes and mIgM, to upregulate IgE synthesis and provoke allergic responses.<br/>To test this hypothesis, purified tonsil B cells were stimulated with IL-4 and anti-CD40 to induce class switching to IgE in vitro. mCD23 was up-regulated …
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Characterization of a Novel Receptor CS1 in Human Lymphocytes; Studies in Natural Killer Cells and B-Lymphocytes
… calcium influx in the presence of monoclonal antibody against CS1 suggesting that CS1-L is an activating receptor. CS1-S showed no effect on the cytolytic function and calcium influx suggesting that CS1-L and CS1-S may differentially regulate human NK cell functions. Although CS1 was also …
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IGE PRODUCTION REGULATION VIA CD23 STALK ENGAGEMENT AND CELL CYCLE STIMULATION
… than at physiological temperature. In addition, antibodies to the stalk region of CD23 were developed and assessed for their capacity to modulate IgE. Rabbit anti-CD23stalk (RAS) antibodies were found to inhibit IgE production in IL-4/antiCD40 stimulated B cells. The inhibition observed was …
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Identification of Metabolic Markers as Potential Early Predictors of PFAS- Induced Immunotoxicity
… T-cell-dependent (TDAR) and T-cell-independent antibody responses (TIAR). Previous studies have demonstrated that exposure to PFAS is associated not only with suppression of the TDAR but also with changes in overall B cell numbers, suggesting disruptions in B cell differentiation. In this study, …
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Effects of estrogen on the B cell functions of normal mice
… expression of a wide variety of IgG and IgM autoantibodies and heteroantibodies that are associated with autoimmune and infectious diseases. These include antibodies to cardiolipin and other membrane phospholipids, dsDNA and acetone-killed Brucella abortus strain RB51. Importantly, the expression …
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Regulation der terminalen B-Zell-Differenzierung durch Blimp-1
… der Maus, die in vitro mit Interleukin-4 (IL-4), anti-mF(ab´)2 oder anti-CD40 in verschiedenen Kombinationen sowohl in An- als auch in Abwesenheit von LPS stimuliert wurden, konnte in der vorliegenden Arbeit gezeigt werden, dass die IgM-Sekretion und die Expression von Blimp-1 durch Signalgebung …