Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"anti-CD19"”.
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Chimeric ANTI-CD19 Monoclonal Antibodies for the Treatment of Precursor B Cell Acute Lymphoblastic Leukemia
… immunotherapies for them are based on anti-CD20 monoclonal antibodies (MAbs). However, CD20 is not expressed on precursor B cell acute lymphoblastic leukemia (pre-B ALL), and CD20 expression is often lost following anti-CD20 immunotherapy. CD19 is a pan B cell membrane antigen that is …
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Evaluierung des Antibody Directed Enzyme Prodrug Therapy-Konzepts im Mammakarzinom- und Lymphom-Mausmodell
… dieser Arbeit war es ein neues Therapiekonzept Antibody Directed Enzyme Prodrug Therapy (ADEPT) in Tieren zu evaluieren. Damit sollte eine höhere Spezifität und Selektivität in der Behandlung von Tumoren erreicht werden. Dabei wurden ein orthotopes Mammakarzinom- mit MDA-MB-231-Tumorzellen in …
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Leveraging Systems Immunology To Understand The Molecular Underpinnings Of Chimeric Antigen Receptor T-Cell Therapy
Chimeric Antigen Receptor (CAR) T-cell therapy is a promising strategy for the treatment of human cancers, and in the last decade has progressed from breakthrough early trials to first in class FDA approvals for B-cell leukemias and lymphomas. Concurrent with the promise and challenges in cancer …
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Engineering Lipid Nanoparticle-Mediated Delivery of Nucleic Acids to Lymphoid Organs and Immune Cells
… vivo. This formulation produced in situ Chimeric Antigen Receptor (CAR) T cells by delivery of mRNA encoding an anti-CD19 CAR. An in vivo Design of Experiment (DOE) to optimize LNPs for spleen pDNA delivery indicated ionizable lipids have the highest delivery efficacy of pDNA to the spleen, …
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Exploiting the Molecular Mechanisms of TAPBPR for use in Cancer Immunotherapy
TAPBPR is a chaperone within the MHC-I antigen processing and presentation pathway, responsible for shaping the immunopeptidome via MHC-I peptide editing and the recycling of sub-optimally loaded MHC-I to the peptide loading complex. As such, TAPBPR plays an essential role in the activation of the …
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Engineering of next-generation chimeric antigen receptors based on alternative binding domains
Exogenous expression of chimeric antigen receptors (CARs) on T lymphocytes (CAR-T) and NK cells (CAR-NK) has allowed the design of effective therapies against lymphoproliferative diseases and has recently achieved success against solid tumors. Given their success, several researchers set out to …