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Showing 1 to 3 of 3 for “"anti-1,3 amino alcohol"”.
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Allylic C—H activation to access anti-1,3-amino alcohol motifs
1,3-Amino alcohols are common motifs in a variety of biologically active molecules including antivirals, antibiotics, antifungals, and various alkaloids. Due to their prevalence and utility as synthetic intermediates, a variety of methods have been developed to access these motifs in a …
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Studies in asymmetric synthesis: I. the asymmetric α-alkylation of N,N-dimethylhydrazones II. the asymmetric aldol-Tishchenko reaction of (S)-tert-butanesulfinyl imines for the introduction of 2, 3, 4 and 5 new chiral centres in one pot
… Recently a new methodology to furnish enantiomerically enriched α-alkylated ketones was developed within the McGlacken group using N,N-dimethylhydrazones as ketone synthetic equivalents and the chiral diamine sparteine. The first section of this thesis outlines efforts to further expand …
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New frontiers in allylic C––H amination via palladium/sulfoxideoxazoline catalysis
… amination that enables unprecedented access to anti-1,3 amino alcohols in good yields (33 substrates, avg. 66%) and high selectivities (avg. 10:1 dr). Switching ligand to (±)-CF3-SOX using a less bulky quinone oxidant (BQ), the kinetic syn- 1,3 amino alcohol motif can be accessed in comparable …