Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 69 for “"anthracis"”.
-
WIP1 Phage Specificity for B. Anthracis
… a recently isolated phage that infects Bacillus anthracis, the notorious biothreat pathogen and gram-positive bacterium that causes anthrax disease. The current standard for identifying suspected B. anthracis involves testing for Wγ phage sensitivity. However, studies have shown that the narrow …
-
Morphogenesis of the Bacillus Anthracis Spore
… the spore during dormancy. The <italic>Bacillus anthracis</italic> spore (the causative agent of anthrax) has three of these protective structures: a specialized peptidoglycan called the cortex, a proteinaceous coat and (flexible) exosporium, the latter of which is studded with collagen-like …
-
Exosporium Morphogenesis in Bacillus Cereus and Bacillus Anthracis
… food poisoning and its close relative, Bacillus anthracis is the etiological agent of anthrax. In both cases, the spore, a differentiated cell type in a dormant state, starts the infection process. Thus, the exosporium, which constitutes the surface of the spore, plays an important role during …
-
Creating Genetic Engineering Tools for Investigating Bacillus anthracis.
<p><em>Bacillus anthracis</em> is a Gram positive, spore forming, non-motile, rod shaped, soil bacterium, and is endemic worldwide. Currently, the biology of <em>B. anthracis</em> is poorly understood. <em>B. anthracis</em> is one of many biological weapons used today. A -/- mutant strain of <em>B. …
-
Host response of lung cells to virulent Bacillus anthracis
Bacillus anthracis, the etiological agent of anthrax, is a Gram-positive, spore-forming bacterium that is classified as a Category A select agent. The current paradigm in anthrax literature labels the alveolar macrophage (MØ) as the primary cell utilized by spores as a safe site for germination and …
-
Functional Characterization of Atxa, The Bacillus Anthracis Virulence Regulator
… expression of virulence genes in <em>Bacillus anthracis</em> occurs via a multi-faceted signal transduction pathway that is dependent upon the AtxA protein. Intricate control of <em>atxA</em> gene transcription and AtxA protein function have become apparent from studies of AtxA-induced …
-
The Immune Inhibitor A1 Protease of <em>Bacillus Anthracis</em>
<p><em>Bacillus anthracis</em>, an organism ubiquitous in the soil and the causative agent of anthrax, utilizes multiple mechanisms to regulate secreted factors; one example is the activity of secreted proteases. One of the most abundant proteins in the culture supernates of <em>B. anthracis</em> …
-
Functional Similarity of Prd-Containing Virulence Regulators In Bacillus Anthracis
<p><em>Bacillus anthracis </em>produces three regulators, AtxA, AcpA, and AcpB, that control virulence gene expression and are members of an emerging class of regulators termed “PCVRs” (Phosphoenolpyruvate-dependent phosphotransferase regulation Domain-Containing Virulence Regulators). AtxA …
-
Control of The Master Virulence Regulatory Gene Atxa In Bacillus Anthracis
<p>Transcription of the <em>Bacillus anthracis</em> structural genes for the anthrax toxin proteins and biosynthetic operon for capsule are positively regulated by AtxA, a transcription regulator with unique properties. Consistent with the role of <em>atxA</em> in virulence factor expression, a …
-
Regulation of the Spore Cortex Lytic Enzyme SleB in Bacillus anthracis
Bacillus anthracis is the causative agent of the disease anthrax and poses a threat due to its potential to be used as a biological weapon. The spore form of this bacterium is an extremely resistant structure, making spore decontamination exceptionally challenging. During spore germination, …
-
REDOX RESPONSE PROFILES OF B. ANTHRACIS LOW-MOLECULAR-WEIGHT THIOL DEFECIENT STRAINS
… eukaryotic and prokaryotic species, Bacillus anthracis does not
-
INVESTIGATION OF UNIQUE COENZYME A BIOSYNTHETIC AND REDOX FUNCTIONS IN Bacillus anthracis
… thiol in the human pathogen Bacillus anthracis. A novel type III pantothenate kinase (PanK) catalyzes the first committed step in the CoASH biosynthetic pathway in B. anthracis. The 2.0 Å crystal structure of the B. anthracis PanK (BaPanK) demonstrates that it is a new member of the …
-
Expression of Bacillus Anthracis Protective Antigen in Vaccine Strain Brucella Abortus Rb51
Bacillus anthracis is a facultative intracellular bacterial pathogen that can cause cutaneous, gastrointestinal or respiratory disease in many vertebrates, including humans. Commercially available anthrax vaccines for immunization of humans are of limited duration and do not protect against the …
-
Roles of Small Rnas and Paralogous Proteins In Bacillus Anthracis Virulence Gene Regulation
… the virulence plasmid pXO1 of <em>Bacillus anthracis</em>, the causative agent of anthrax. The sRNAs, named “XrrA and XrrB” (for pXO1-encoded regulatory RNA) are abundant and highly stable primary transcripts, whose expression is dependent upon AtxA, the master virulence regulator of <em>B. …
-
Characterization of the Bacillus anthracis SleL Protein and its Role in Spore Germination
Bacillus anthracis is a spore-forming bacterium that is included on the list of select agents compiled by the Centers for Disease Control. When a B. anthracis spore germinates, a protective layer of peptidoglycan known as the cortex must be depolymerized by germination-specific lytic enzymes …
-
Kinetic and structural studies on the first three enzymes in Bacillus anthracis isoprenoid biosynthesis.
… studies on the first three enzymes in Bacillus anthracis isoprenoid biosynthesis.
-
Structure and function analysis of the natural product plantazolicin, a bacillus anthracis-specific antibiotic
… selective antibiotic activity against Bacillus anthracis. This remarkably discriminatory activity rivals a previously-described B. anthracis-specific gamma (γ) phage lysis assay in distinguishing B. anthracis from other members of the Bacillus cereus group. I evaluate this unusually selective …
-
Structural and Functional Characterization of B. Anthracis Udp-Glcnac 2-Epimerase and Salmonella Secreted Effector I
… has been taken towards the study of the Bacillus anthracis cell-wall enzyme UDP-GlcNAc 2-Epimerase and the Salmonella secreted virulence effector SseI. UDP-GlcNAc 2-Epimerase is an essential B. anthracis enzyme required for formation of the peptidoglycan cell wall precursor UDP-ManAc. We have …
-
The Roles of the Germination-Specific Lytic Enzymes CwlJ1, CwlJ2, and SleB in Bacillus anthracis Spores
The Bacillus anthracis spore is highly resistant to environmental stresses, but cannot cause anthrax until it successfully germinates. An essential step of germination, degradation of the cortex peptidoglycan layer, is carried out by germination-specific lytic enzymes (GSLEs). While the GSLEs of …
-
Influence of site and soil type on the distribution of anthrax infectious sites and the contribution of anthrax to elephant mortality in Ethosha National park, Namibia
Bacillus anthracis, a soil-borne pathogen, causes the deadly zoonotic disease anthrax. Anthrax outbreaks occur frequently in Etosha National Park (ENP). ENP has nine major soil types and a distinct rainfall gradient decreasing from east to west. The sporulation success of B. anthracis is believed …
Page 1 of 4