Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"anthelmintic"”.
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Novel Approaches for Anthelmintic and Nematicide Discovery
… food security. We rely heavily on the use of anthelmintic medicines and agrochemical nematicides to control these devastating parasitic nematode infections. The development of genetic resistance to anthelmintics and the phase-out of effective nematicides due to environmental toxicity and human …
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Stability evaluation of selected anthelmintic macrocyclic lactone compounds and formulations
… and subtropical human populations. Various anthelmintic drugs and their preparations are used for control of these parasites. Macrocyclic lactone (ML) compounds such as avermectins (e.g. abamectin, ivermectin, eprinomectin) and milbemycins (e.g. milbemycin oxime and moxidectin) are among …
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Advanced systems for the rapid detection of anthelmintic drugs in food
… developed and validated for the detection of anthelmintic veterinary drugs in liver tissue and milk using a QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) extraction procedure. The first screening assay was developed to detect 11 benzimidazole carbamates in milk and liver. In bovine …
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Phosphoethanolamine methyltransferases inhibitors with broad-spectrum anthelmintic effect against livestock nematodes
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-08-01
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The anthelmintic effect of Bacillus thuringiensis Cry5B on Haemonchus contortus in sheep
Widespread anthelmintic resistance in trichostrongyle nematodes of ruminants has created an urgent need for alternatives to commercial anthelmintics. The bacterium Bacillus thuringiensis (Bt) can produce crystal proteins during sporulation, which can be lethal to insects in multiple orders when …
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The Search for Novel Anthelmintic Targets: Characterizing Alternative Metabolic Pathways in Caenorhabditis elegans
… on the agricultural industry. Unfortunately anthelmintic resistance is a growing problem. Helminths survive long periods of low to no oxygen in their hosts, but their anaerobic metabolism has yet to be fully characterized. The goal of this project has been to characterize the anaerobic …
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Investigation into potential Dirofilaria immitis drug targets through rational anthelmintic synthesis and design
… due to several factors including climate change. Anthelmintic resistance is becoming increasingly problematic and as such, the aim of this thesis was to synthesize several novel compounds and examine their activity on the anthelmintic receptor targets of interest, ACC-2 which is an …
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An investigation into the anthelmintic properties of seed extracts from endophyte containing pasture grasses
The study investigated the in vitro anthelmintic properties of extracts from seeds containing the endophytes AR1, AR37, wild type in perennial rye grass (RG), and the loline producing endophytes namely Meadow Fescue (MF and U2) and Tall Fescue (TF and AR542) with Nil endophytes rye grass (Nil RG) …
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Evaluation of Anthelmintic Properties and Toxicity of Pure Compounds Isolated from Dalea Spp (Plantae, Fabaceae)
… is emerging. Due to this resistance, finding new anthelmintic compounds active against hookworm is a priority. Previously, a pure compound isolated from <em>Dalea ornata </em>was identified as having strong anthelmintic activity when used against the hookworm <em>Ancylostoma ceylanicum</em>. This …
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In vitro evaluation of nutritional content and anthelmintic values of Kigelia africana fruit to domesticated ruminants
… fruit) as a potential feed supplement and its anthelmintic value in domesticated ruminants. Five feed portions were made from the sausage fruits; 1. Exocarp (Ex), 2. Endocarp (En), 3. Endocarp plus seeds (En+SS), 4. Seeds (SS) and 5. Whole fruit (Wf). The nutritional value of feed portions was …
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Experimental design and mathematical modelling methods for the study of anthelmintic resistance in UK livestock populations
… widely used field based method for estimating anthelmintic efficacy and as an indicator of anthelmintic resistant nematodes in cattle. In this thesis, statistical aspects such as the analysis of cattle faecal egg count (FEC) data and the identification of statistically robust experimental study …
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Chemogenomic approaches to drug design : docking-based virtual screening of nematode GPCRs for potential anthelmintic agents
… the animal populations. However, the current anthelmintics are no longer as effective and some strains have developed resistance thus increasing the need for new anthelmintics. Unfortunately, not too much information is available detailing the physiology of helminths. The published genomic …
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An investigation into the mode of action of the anthelmintic emodepside: a molecular, pharmacological and electrophysiological characterisation
Resistance to anthelmintics is increasingly becoming a problem for the agricultural industry. Emodepside is a novel anthelmintic that is effective against a variety of parasitic nematodes in which resistance to other anthelmintics has developed (Harder and Samson-Himmelstjerna, 2002). This suggests …
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Anthelmintic Screening, Phytochemical Analysis and Cytotoxicity Determination of the Indigenous Plants of the U.S.A. Northern Great Plains
… conventional anthelminthics. The appearance of anthelmintic resistance with the overuse of anthelmintics has created a greater need to look for the alternative source for anthelmintics. Therefore, this thesis focuses on evaluating medicinal plants from the USA Northern Great Plains for …
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A Quantitative Description of Anthelmintic and Prednisolone-Induced Alterations in the Ultrastructure of Hepatic Parenchymal Cells of the Beagle
Made available in DSpace on 2014-12-09T22:30:25Z (GMT). No. of bitstreams: 1 7013281.pdf: 3608332 bytes, checksum: d56206f5f06c71422a2384fa4edebf65 (MD5) Previous issue date: 1969
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Molecular Diagnosis and Anthelmintic Control of Trichostrongyle and Toxicara nematodes in Bison bison Herds from the U.S.A. Central Great Plains
<p>Bison producers face many challenges, including the transmission of parasitic diseases such as trichostrongylosis and toxocariasis into and within their herds. These diseases can reduce animal production and cause occasional death. There have been no surveys to identify gastrointestinal …
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Investigations into the use of continuous low-level medication for the control of helminths in the ruminant
… parasite infestations in the ruminant with the anthelmintic thiophanate [diethyl 4,4'-o-phenylene bis (3-thioallophanate)]. A new concept of administration was investigated, namely continuous low-level anthelmintic medication. Two aspects were studied which divide conveniently into two sections. …
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Interactions and epidemiology of nematode worm control in livestock
The livestock industry relies heavily upon anthelmintics for the treatment of parasitic nematode diseases. This has resulted in widespread resistance to multiple anthelmintic classes across several parasitic genera. In response to this spread in resistance and subsequent decrease in efficacy there …
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Endoparasites of working donkeys in Ethiopia: epidemiological study and mathematical modelling
… faecal egg output, and in simulating anthelmintic control strategy. The model is based on parameters of biological development of cyathostomins and climatic data. A good fit of the model prediction to the field data was obtained after some parameter adjustments. The development rate of …
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