Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"antagonistic effect"”.
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The Selection of Aptamers to CD20 and Their Application as Inhibitors of Complement Dependent Cytotoxicity
… cell line. Sequenced aptamer clones exhibited an antagonistic effect with anti-CD20 antibody; and in a biological assay possessed a protective capacity, limiting the extent of antibody induced complement dependent cytotoxicity. Overall, genetic transfection is a novel targeted approach of ligand …
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Evaluation of southern African maize germplasm for phytoalexin accumulation following inoculation by Fusarium verticillioides
… which have been linked to adverse health effects in both humans and animals. Maize produces terpenoid phytoalexins, which are antimicrobial compounds that directly reduce the growth of many fungal pathogens including F. verticillioides. Two families of maize phytoalexins, termed …
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Novel Agonists and Antagonists of Platelet Receptors
… mild hypothermia has been accepted, but its effect on platelet activation is unclear. We performed a comparative ex vivo study on platelets, treated with mild hypothermia and normothermia in the presence of P2Y12 inhibitors. We found that mild hypothermia increased platelet P2Y12 activation …
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Toxicity of zinc, copper, and sediments to early life stages of freshwater mussels in the Powell River, Virginia
… with glochidia and juvenile freshwater mussels. Effects of varying conditions such as water source, temperature, length of exposure, species, and lifestage were determined. Additionally, the effects of Powell River sediment on survival and growth of juvenile mussels were evaluated. The Cumberland …
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Amelioration of acute and chronic toxicity of imidacloprid by dietary phytochemicals in honey bees (apis mellifera)
… the diet of honey bees may ameliorate the toxic effects of imidacloprid. In order to determine the effect of quercetin and/or p-coumaric acid on honey bees in the presence of imidacloprid, both acute and chronic toxicity bioassays were conducted. Honey bee imidacloprid LC50 values, the median …
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Investigating the role of the Renin Angiotensin System in cancer
… an AT1R blocker significantly reduced these effects. ACE-2 expression and activity were decreased in cancer compared to normal cells. Our data shows that ACE2 activators, the natural peptide angiotensin 1-7 and small molecule Diminazene aceturate (DIZE) have anticancer effects with DIZE …
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Studies on the stability and activity of polymyxin B solutions.
… was used as an inactivating recovery medium. The effect of preservatives and of second antibacterials contained in the eye drops were tested individually and combined with polymyxin B. Thiomersal 0.001 %w/v, trimethoprim 0.02 %w/v and thiomersal 0.001 %w/v plus trimethoprim 0.02 %w/v did not have …
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An investigation of the cellular effects of novel agents and multi-drug combinations in cystic fibrosis
… Compounds which had the highest inhibitory effect against TLP activity across various models were then investigated for their ability to inhibit ENaC. Electrophysiological assessment of the four compounds however, found that none were able to effectively prevent the proteolytic activation of …
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Role of cavitation, surfactants, and their synergism in transdermal sonophoresis
… surfactants in LFS skin treatments, and iv) the effects of LFS and LFS/CPEs on skin structural perturbation. In the first study of this thesis, the intrinsic properties and formation mechanisms of localized-transport regions (LTRs), and the surrounding less-perturbed non-LTRs, of lowfrequency …
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GRAPEVINE-ASSOCIATED MICROORGANISMS AS BIOCONTROL AGENTS AGAINST THE PROLIFERATION OF PATHOGENIC FUNGI
… exploit these metabolic traits to optimize the antagonistic effect under different plant growth conditions and grape management. Chapter 1 focuses on developing techniques for isolating grapevine endophytes, both cultivable and non-cultivable. A total of 148 endophytes were isolated and …
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Developing novel therapeutic agents for Acanthamoeba infection and investigating the process of encystment
… chloride). The anti-amoebic effect of benzalkonium chloride, povidone iodine and tetracaine are superior to the current diamidines and slightly lower to the biguanides applied in the treatment for AK. The formulation of novel amidoamine compounds including …
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Cell wall metabolite levels as a function of the growth phase in Staphylococcus aureus and library screening for synergistic combinations of FDA approved drugs against methicillin resistant S. aureus
… and floxuridine showed weak synergy. A similar antagonistic effect of mupirocin on ceftobiprole was also observed in other studies showing that it led to β-lactam resistance. We also performed a high-throughput library screening of FDA-approved drugs in the presence and absence of floxuridine …
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Secondary Metabolites from Otanthus maritimus, Stachys glutinosa and Withania somnifera: Isolation, Structure Elucidation and Interactions with Cannabinoid and Opioid Systems
… in the tail flick test, suggesting an antagonistic effect at μ opioid receptor. As regards WSE and WSAE, the results of the binding assays (Table 10) for the μ, CB and GABAA receptors suggested a possible anti-‐nociceptive effect of W. somnifera. Starting from these preliminar data and …
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Možnosti produkce pigmentů kvasinkami
… V poslednej dobe sa intenzívne študuje jeho antagonistický efekt, ktorý vykazuje voči viacerým mikroorganizmom, čo sa javí ako veľmi významné z hľadiska biologickej kontroly. Druhá časť práce je venovaná práve štúdiu regulácie produkcie pulcherimínu a jeho antimikrobiálnej aktivite. Ako …
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Endocranial volume and shape variation in early anthropoid evolution
… the endocranium and facial skeleton will have an antagonistic effect on basicranial angle and facial hafting. Results show that various measures of globularity have inconsistent and weak relationships to phylogeny, encephalization, and basicranial flexion, owing to a diversity of clade-specific …
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Anti-inflammatory and anti-colon cancer potential of yerba mate (Ilex paraguariensis St. Hilaire) bioactive constituents
… of yerba mate are involved in the protective effects against colon carcinogenesis is not clearly understood. The objective of this study was to evaluate the dietary prevention of colon carcinogenesis by identifying novel constituents in yerba mate. The first aim was to investigate the …
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Molecular mechanisms of bioactive compounds in fruits and vegetables that inhibit pancreatic cancer and their relationship with inflammation
… objective of this research was to examine the effect of bioactive compounds present in fruits and vegetables on pancreatic cancer proliferation, apoptosis, and the role of the GSK-3β/NF-κB signaling pathway using in vitro and in vivo models. In aim 1, we evaluated the ability of fruit and …
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Viral HSV1-TK gene, radiolabeled FIAU, and ganciclovir: combined gene targeted radiotherapy and suicide gene therapy for prostate cancer
… and a period equal to their doubling times. The effect of this treatment on cell cycle progression was assessed by FACS analysis after staining the cellular DNA with propodium iodide. Combination therapy using GCV and [123I]FIAU for the treatment of TK-positive clones of the prostate cancer cell …