Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 379 for “"antagonism"”.
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Dermatophyte Respiration Antagonism in Vitro by Juglone
Centuries before juglone was isolated and structurally analyzed it was employed as a medicinal ingredient in combating venereal diseases, eczema, mycotic infections, gastro-intestinal disorders and a number of varied pathologically unrelated diseases. Juglone, 5-hydroxy-1, 4-naphthoquinone, is a …
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Mechanism of anaesthetic activation, combination and antagonism
The type A γ-aminobutyric acid receptors (GABAAR) – pentameric ligand gated ion channels (pLGICs) – are the main mediators of fast inhibitory neurotransmission in the human brain. Malfunctions in these receptors are a common cause for neurological disorders such as anxiety, epilepsy, schizophrenia …
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Antagonism of Streptomyces Hygroscopicus Var. Geldanus to Rhizoctonia Solani
Antagonism between soil microorganisms is a common phenomenon. However, little is known of the mechanisms by which antagonism occurs. This investigation was designed to understand the nature of antagonism between Streptomyces hygroscopicus var. geldanus and Rhizoctonia solani and the mechanism by …
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Agonism and Antagonism: Past and Future Possibilites of Radical Democracy
Though radical democratic theory has become a mainstay in progressive political thought, it is clear that more work needs to be done in terms of establishing the empirical bases for its appearance and continuation. As such, through a comparative investigation and analysis of historical episodes of …
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Whitby, Wilfrid, and church-state antagonism in Early Medieval Britain.
In 664, adherents of the Dionysian and Celtic-84 Easter tables gathered at the Northumbrian abbey of Whitby to debate the proper calculation of Easter. The decision to adopt the former, with its connections to the papacy, has led many to frame this encounter in terms of Roman religious imperialism …
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Transcription factor antagonism regulates heterogeneity in embryonic stem cell states
… of switching between states. These results show antagonism between factors at enhancers results in gene expression heterogeneity and formation of cell states, with implications for the generation of diverse cell types during development.
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Co-encapsulation of anti-breast cancer drugs in nanoparticles reduce antagonism
… drugs from metabolizing enzymes to reduce this antagonism, remained unknown. We demonstrated that after the co-delivery of DCL and TAM in poly (lactide)-D-a-tocopheryl polyethylene glycol succinate nanoparticles (PLA-TPGS NPs), drug antagonism was significantly reduced versus its free …
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Innate immune evasion and interferon antagonism by porcine epidemic diarrhea virus
… responses. In the present study, the PEDV IFN antagonism was investigated. We found that IFN-β production was significantly suppressed during PEDV infection, and of 16 PEDV nonstructural proteins (nsps), nsp1, nsp3, nsp7, nsp14, nsp15, and nsp16 were found to inhibit the IFN-β and IRF3 promoter …
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Settler and Administration Antagonism in Colonial German East Africa, 1885-1925
This dissertation argues that a study of the distinct experiences of the colonialism of settlers, administration in German East Africa, and the metropolitan government in Germany provides a more nuanced understanding of German colonialism as a whole. The relations between these groups were …
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Exploiters and exploited: antagonism, mutualism and mimicry in an ecological community
… broader context for the ecology and evolution of antagonism. First, I attempt to synthesise our understanding of analogous antagonistic systems, since exploiters and exploited parties exist from sub-cellular to super organismal levels. Second, I focus empirically on a pairwise interaction between …
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Functional antagonism of the RNA polymerase II holoenzyme by negative regulators
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1997.
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Glutamine Antagonism and Its Utlity [sic] as a Therapeutic Modality in Cancer
Glutamine metabolism is important in cancer as it fuels the TCA cycle, plays a role in redox homeostasis, and contributes to the production of nucleotides, amino acids, and lipids for survival, making glutamine metabolism a promising target in cancer therapy. The work outlined in this dissertation …
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New protein engineering approaches for potentiating and studying antibody-based EGFR antagonism
… rates low. Opportunities for improving EGFR antagonism include higher potency inhibition of ligand binding, inducing receptor downregulation, or creating synergistic therapeutic combinations. The Wittrup lab has previously made significant advances in EGFR antagonism by demonstrating the …
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Effects of opioid antagonism on thermoregulation during prolonged exercise in the heat
Five adult male volunteers were studied to investigate the effect of opiate receptor blockade on the physiological response to a maximum of 60 minutes of stationary cycling at 70% V02peak in a hot (33 0 C/65% RH) environment. Exercise bouts were conducted following the administration of naloxone …
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Deletions in SARS-CoV-2 nsp6 enhance antagonism of type-I interferon signaling
… through the formation of replication organelles, antagonism of interferon type I (IFN-I) responses, and NLRP3 inflammasome activation, a major factor of severe COVID-19. Here, I review the most recent published findings regarding the multiple roles of nsp6 in promoting SARS-CoV-2 replication and …
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The Royal Navy and Soviet seapower, 1930-1950 : intelligence, naval cooperation and antagonism
… World War and, finally, a shift towards Cold War antagonism.It is argued that the Admiralty's Naval Intelligence Division was able to collect sufficient data to maintain a credible intelligence picture of the Soviet Navy's order of battle and war-fighting capabilities, thereby allowing informed …
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Characteristics of biological control agents and their antagonism against rice pathogens and pests
… amyloliquefaciens and P. macerans did not show antagonism against Xanthomonas oryzae pv. oryzae. Putative antimicrobial peptide-encoding genes were amplified from Bacillus sp., but not B. amyloliquefaciens. However, more studies needs to be conducted to confirm the identity and functional …
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Hormonal and metabolic responses to opioid antagonism during dynamic exercise : influence of exercise intensity
… modestly (7%) elevated in 90%-NAL. Thus, opiate antagonism prevents the decline in serum glucose seen in prolonged exercise without altering substrate oxidation, and with minimal influence on the pancreatic hormone response. In contrast, opiate antagonism potentiates the hyperglycemic response to …
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Behavioral alterations in rat offspring following maternal immune activation and CXC chemokine receptor antagonism
… study the effects of MIA and chemokine receptor antagonism on the behavior of rat offspring, with behavioral tests chosen to examine cognitive functions that are typically impaired in human schizophrenia patients. The viral mimetic polyinosinic-polycytidylic acid (polyI:C) (4.0 mg/kg, i.v.) was …
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