Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"anoikis"”.
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Dual Assembly Nanoparticles Achieve Sustained Silencing of Znf304: A Novel Transcription Factor For Β1 Integrin
… adhesion kinase and paxillin and prevents anoikis. Targeting ZNF304 using small interfering RNA (siRNA) reduces cell survival, anoikis and migration in vitro. A novel dual assembly nanoparticle system (DANP) was designed for in vivo delivery and sustained gene silencing. DANP-ZNF304 siRNA …
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MUC13 Enhances Colorectal Cancer Metastasis
… intravasation, anchorage independent survival (Anoikis resistance) of primary tumor cell is one of the key steps in metastasis.</p> <p>The mucin MUC13 when aberrantly overexpressed in cancer has been found to lead to poor outcomes in Pancreatic, Ovarian, Liver, and Colorectal cancer. When …
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Sustained Adrenergic Signaling Promotes Cervical Cancer Progression
… to examine intracellular responses. Invasion and anoikis assays were performed to elucidate the biological effect of NE. Furthermore, the significance of secreted HPV was examined.</p> <p>Results: Among tumor samples evaluated from cervical cancer patients, 61% had increased ADRβ2 expression which …
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The importance of the tissue transglutaminase-fibronectin heterocomplex in the RGD-independent cell adhesion and fibronectin matrix deposition
… to the loss of cell adhesion and ultimately Anoikis. This study provides a mechanism for TG2, as a stress-induced matrix protein, in protecting the cells from the RGD-dependent loss of cell adhesion and rescuing the cells from Anoikis. Mouse fibroblasts were used as a major model for this …
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Asthma: Cytokine-Induced Over-Expression of Matrix Metalloproteases Compromises Airway Epithelium Tight Junctions and a Clinical Case Study
… MMP9 encourages detachment-induced cell death - anoikis - which results in a structural change compromising the airway epithelium's ability to act as a primary immune defense mechanism. The chronic characterization of asthma results because of an ineffective epithelial repair mechanism which …
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Upregulation of Cystathionine-β-synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis
… invasion through Matrigel, resistance to anoikis, and CBS-dependent tumorigenesis in immunocompromised mice. CBS expression enhances cell bioenergetics and regulates cell metabolism, by inducing a metabolic reprogramming (anabolic metabolism) that is characterized by increased anaerobic …
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Identification of a novel metastasis enhancer, CDCP1, and analysis of its functions during melanoma metastasis
… the balance between cell proliferation and anoikis. Making use of 3D Matrigel culture system, we found that CDCP1 also regulates scattered growth of melanoma cells. We speculate these two factors may contribute to enhanced-metastatic ability observed in mice.
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RET receptor activation targets expression of the pleiotropic cytokine interleukin-11
… the proliferation, adhesion, or survival against anoikis in the cells. Immunohistochemical analyses of human thyroid tissues revealed that RET, IL-11, and IL-11Rα are expressed in thyroid cells of the normal thyroid, MTC and PTC. Expression of the three molecules was also detected in immune cell …
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The role of anchorage in cell cycle control
… either cell-cycle arrest or cell death, known as anoikis, due to activation of anchorage-dependent checkpoint mechanisms. Transformed cells alleviate these checkpoints, via activation of oncogenes and/or inactivation of tumour suppressors. In contrast, detachment of normal cells halts cell-cycle …
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Role of e-cadherin in tumor metastasis and discovery of compounds targeting metastasis cancer cells
… transition (EMT), invasiveness and anoikis-resistance. E-cadherin binding partner f3-catenin is necessary but not sufficient for these phenotypes. In addition, gene expression analysis shows that E-cadherin loss results in the induction of multiple transcription factors, at least one …
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Inhibition of biofilm growth on highly polycationic polyelectrolyte multilayers
… transition (EMT), invasiveness and anoikis-resistance. E-cadherin binding partner f3-catenin is necessary but not sufficient for these phenotypes. In addition, gene expression analysis shows that E-cadherin loss results in the induction of multiple transcription factors, at least one …
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The transcription factor grainyhead-like 2 is a novel suppressor of the epithelial to mesenchymal transition
… GRHL2 acted as a tumor suppressor as it enhanced anoikis, suppressed anchorage independent growth and invasion, and prevented tumor formation in xenograft assays. Wnt and TGF-beta were shown to down regulate GRHL2 by up-regulating ZEB1 which directly repressed its promoter. This body of work has …
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Molecular Characterization of Trefoil factor 1 in Gastric Carcinoma
… promotes cell migration and invasion, prevents anoikis and has also been associated with angiogenesis. Studies have demonstrated that an increase in the expression of TFF1 in mammary carcinoma enhances oncogenic properties, but the effector molecule(s) mediating these functions have not been …
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Molecular Mechanisms of Programmed Necrotic Death Initiated by Intrinsic Death Signals
… stress induced by oxidants, DNA damage, and anoikis, while deficiency of DeltaNp63alpha increased oxidative stress and sensitized to oxidant-induced death. I further found that long-term survival of anchorage-dependent cells following loss of matrix attachment was enhanced by combined …
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The Role of Extracellular Matrix Rigidity and Altered microRNA Expression In TGF-beta-Mediated Breast Cancer Progression
… Bim, which sensitized metastatic cells to anoikis. Along these lines, miR-181a activity was essential in driving pulmonary micrometastatic outgrowth and enhancing the lethality of late-stage mammary tumors in mice. Finally, miR-181a expression is dramatically and selectively upregulated in …
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Functional characterization of mobilized tumor cells
… potential. These CTCs were resistant to anoikis, were invasive or secreted proteolytic enzymes. The second part of this thesis determines the presence of intraoperatively shed tumor cells using blood samples withdrawn from the pulmonary vein after pulmonary lobectomy procedures. Previous …
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Role of Talin1 Phosphorylation In Beta1 Integrin Activation and Prostate Cancer Metastasis
… and increased the sensitivity of cells to anoikis. In contrast, re-expression of the phosphorylation-mimicking mutant, talin1<sup>S425D</sup> led to increased β1 integrin activation and generated biologic effects opposite to talin1<sup>S425A</sup> expression. Mechanistically, I demonstrated …
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The Antitumor Agent, Arglabin-DMA, Preferentially Induces Apoptosis in Human Colon Tumor Cells
… apoptosis. This mechanism may be analogous to "anoikis," which is the induction of apoptosis in response to loss of cell contact. The utility of this drug in combating cancer remains an attractive, though complex possibility.</p>
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Roles of Cytoplasmic Deacetylase Hdac6 in Oncogenic Tumorigenesis
… deficient cells is associated with increased anoikis and mechanistically a defect in activation of the AKT and ERK kinase cascades. Additionally, <em>HDAC6 </em>null mice are more resistant to two-stage chemical carcinogen-induced skin tumors. Finally, I have demonstrated that the …
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Taspase1 is a Non-oncogene Mediator of Tumorigenesis and Maintenance
… to a variety of apoptotic stimuli, including anoikis, DNA damaging agents etoposide and doxorubicin, and to a targeted inhibitor of BCL-2 family proteins, ABT-737. We found that Taspase1 is over-expressed in multiple primary human tumors, including glioblastoma and melanoma, suggesting that …
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