Global ETD Search
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Showing 1 to 5 of 5 for “"anoctamin"”.
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Characterization of the sarcolemma in limb-girdle muscular dystrophy
… membrane. Recently, recessive mutations in the anoctamin gene could also be related to LGMDs. As seen for dysferlinopathies, ANO5 mutations can lead to a LGMD or MM clinical phenotype. Anoctamin-5 is a member of the anoctamin protein family and is thought to function as calcium- activated …
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Gastrointestinal (GI) Motility is Unaltered by Feeding in Zebrafish
… Acid and DIDS were also examined, because anoctamin 1 (ANOl), a chloride-selective channel, has recently been identified as a potential regulator for ICC pacemaker function. Both drugs dramatically reduced the total number of contractions as well as the GI motility index indicating a …
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Functional Asymmetry of The Immune Cell Plasma Membrane
… chloride channel protein known as TMEM16F (or Anoctamin 6; Ano6). The scrambling activity of this channel is gated by intracellular calcium, with increased Ca<sup>2+</sup> levels leading to channel opening and rapid movement of PS from the inner leaflet to the outer. During cell death and …
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Keeping Pace with Interstitial Cells of Cajal: Modelling Gastrointestinal Electrophysiology
… a Ca2+-activated chloride (Cl ) channel called anoctamin 1 (Ano1), which is activated by a localised increase in intracellular Ca2+ concentration ([Ca2+]i). Cyclical release of Ca2+ from intracellular stores is believed to initiate pacemaker activity, so Ano1 was proposed to be activated by Ca2+ …
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A functional study on novel genes involved in regulating aldosterone secretion in normal human zona glomerulosa and in aldosterone-producing adenomas
Primary aldosteronism is the most common secondary cause of hypertension with a prevalence of about 10%. About half of PA cases are caused by aldosterone-producing adenomas (APA). Two APA subtypes, ZG-like and ZF-like APAs, have been described, according to the histological resemblance to normal …