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Showing 1 to 7 of 7 for “"annulation strategy"”.
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Intramolecular [4 + 2] cycloadditions of conjugated enynes with highly strained cyclic alkenes
… directed towards the development of a [4 + 3] annulation strategy for the synthesis of seven-membered carbocycles involving the intramolecular [4 + 2] cycloadditions of conjugated enynes with cyclopropenes. A new [4 + 4] annulation method has been developed for the synthesis of eight-membered …
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Studies directed toward the total synthesis of salvilenone
… miltiorrhiza Bunge, are reported via a double annulation strategy. The key steps in the proposed synthesis involve a regiocontrolled benzannulation involving the photochemical Wolff rearrangement of an a-diazo ketone and an alkoxy acetylene moiety which assembles an aromatic ring in one step …
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[4 + 1] annulation reactions of (trialkylsilyl)ketenes : synthesis of substituted indanones and cyclopentenones
… and heterocyclic compounds. A new [4 + 1] annulation strategy for the synthesis of substituted 2-indanones, based on the reaction of TAS-arylketenes with trimethylsilyl diazomethane, has been developed. In addition, a new class of carbenoid reagents for our previously reported [4 + 1] …
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Annulation strategies for the synthesis of azulenes and polycyclic nitrogen heterocycles
Highly convergent annulation strategies have been developed for the synthesis of azulenes and polycyclic nitrogen heterocycles. Specifically, substituted azulenes have been synthesized via a ring expansion-annulation strategy based on n-halo diazo ketones. The method employs the use of readily …
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Total synthesis of Class II and Class III Galbulimima Alkaloids
… the C-ring while successful execution of our strategy for introduction of the CDE-ring system in complex galbulimima alkaloids provided the target pentacycle with complete diastereoselection. II. Total Synthesis of (-)-Himandrine We describe the first total synthesis of (-)-himandrine, a …
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Pericyclic reactions in organic synthesis
… a formal, metal-free, [2 + 2 + 2] cycloaddition strategy based on a cascade of two pericyclic processes. An intramolecular propargylic ene reaction of a 1,6-diyne is used to generate a vinylallene, which then reacts in an inter- or intramolecular Diels-Alder reaction with an alkenyl or alkynyl …
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Total synthesis of marine terpenoids
… fashion. To facilitate the development of strategy and completion of the total synthesis, a number of tools at our disposal were utilized, such as computational techniques and a high-throughput screening platform. Enormous strain associated with the core motif manifested itself in various …