Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"anionic phospholipid"”.
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Molecular Basis of Cell Membrane Adaption Against Daptomycin in Enterococcus faecalis
… to avoid daptomycin killing by redistributing CM anionic phospholipids away from the septum. The CM changes are orchestrated by a three-component regulatory system, designated LiaFSR, with a possible contribution of cardiolipin synthase (Cls) (Cesar A Arias et al., 2011a; Khan et al., 2019b; …
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The regulation of blood coagulation by high-density lipoprotein particles
… complexes that assemble on the surface of anionic phospholipids, e.g. activated platelets. Lipoproteins contain a phospholipid surface, which may provide another phospholipid surface, other than platelets, that could stimulate the reactions of blood coagulation. Lipoproteins have been …
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Membrane Surface Charge and Lipid Signaling in Phagocytosis
… events. Sphingolipids, cholesterol and glycerophospholipids, notably the phosphoinositides, are required for the segregation of signaling microdomains and for the generation of second messengers. They are also instrumental in the remodeling of the actin cytoskeleton and in directing membrane …
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Solid-State NMR Studies of Polymeric and Biomembranes
… thinned bilayers in oriented zwitterionic and anionic phospholipid bilayers, (biomembrane mimetic systems), by the antimicrobial peptides (AMPs) magainin-2 and aurein-3.3, will be mentioned. The toroidal pore geometries induced by magainin-2 were different than those produced by aurien-3.3. The …
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Targeting phosphatidylserine exposure in pro-coagulant platelets.
… both thrombosis and haemostasis. They expose the anionic phospholipid, phosphatidylserine (PS), in their outer leaflet enabling coagulation complex assembly on the negatively charged surface. Assembly of the tenase and prothrombinase complexes enhances their activity, increasing thrombin …
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Targeting Nanoparticles to Tumor Vasculature
… targeting, I used Fab' fragments derived from an anionic phospholipid binding antibody (bavituximab) and also a serum protein, beta-2-glycoprotein 1 (beta 2GP1). PE was targeted using a small antibiotic peptide, duramycin. All the liposome constructs bound to the purified target, as tested by …
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The Membrane as a barrier or target in cancer chemotherapy
… bacterial strains expressing different levels of anionic phospholipid were compared. Giowth of wild-type Echerichia coli (E. coli) strain MRE600 was severely affected up to 9 hours following doxorubicin treatment (15uM), but resistance occurred after 9 hours. E. coli strain FIDL1 1 was resistant …
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Identification of cellular functions of cardiolipin as physiological modifiers of barth syndrome
<p>Cardiolipin (CL) is an anionic phospholipid synthesized in the mitochondrial inner membrane. Perturbation of CL metabolism leads to Barth syndrome (BTHS), a life threatening genetic disorder. I utilized genetic, biochemical and cell biological approaches in yeast to elucidate the cellular …
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Characterization of the cardiolipin synthase from arabidopsis thaliana
Cardiolipin (CL) is an anionic membrane phospholipid of a unique tetraacyl structure, consisting of two phosphatidyl moieties linked by a glycerol bridge. It constitutes the cytoplasmic membrane of eubacteria and represents the marker lipid of mitochondria in eukaryotes, where CL is predominantly …