Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 936 for “"animal models"”.
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OVARIAN TISSUE BANKING IN ANIMAL MODELS
… end point evaluation tools for feline and bovine models. In the quest for reliable fixation techniques suitable for both morphological and immunohistochemical assessment of ovarian tissue, this thesis has provided an in-depth perspective on the effect of fixatives on both morphological and …
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Development of animal models in pediatric cancer
… efficacies of novel compounds in preclinical models of neuroblastoma and Section 2 details the development of an experimental animal model for childhood leukemia. The study on neuroblastoma was designed to test a panel of reversible and irreversible inhibitors of cathepsin B and L to induce …
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Neuromodulation in Experimetal Animal Models of Epilepsy
… LEV can act rapidly on seizures in both animals and humans. In addition, preclinical studies suggest that LEV may have anti-epileptogenic and neuroprotective effects, with the potential to slow or arrest disease progression. VNS as well can have an immediate effect on seizures in animals …
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Animal models for investigating coronavirus heterotypic immunity
… SARS-CoV-2 infection. Prior to 2020 no animal models existed for any of the four endemic CoVs, so the degree to which endemic CoVs produce lung-resident memory and the potential contributions of this to heterotypic immunity is unknown. In these studies, we utilized both rodents and …
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Reductionist animal models to probe protein O-GlcNAcylation
… of nucleocytoplasmic proteins occurring in all animals examined to date. Its installation on protein substrates is carried out by O-GlcNAc transferase (OGT), and its removal by O-GlcNAc hydrolase (O-GlcNAcase or OGA). A range of proteomics studies have suggested that over a thousand …
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Lutein and α-tocopherol biodistribution in animal models
… bioaccumulation of lutein and αT in appropriate animal models. In Chapter 2, we explored the bioaccumulation of lutein in infant rhesus macaques fed formulas with high or low levels of carotenoids (lutein, zeaxanthin, β-carotene and lycopene) for 4 months (n=2/group). All samples were analyzed by …
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Phytoecdysteroid accumulation in plants and bioactivities in animal models
… were examined in in vitro and in vivo mouse models. Results showed that A. turkestanica hairy root cultures were a sustainable alternative source of valued phytochemicals compared to wild-harvesting (Chapter 2). Extracts from both wild-harvested A. turkestanica shoots and hairy root cultures …
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Biochemical changes in animal models of fetal alcohol spectrum disorder
… latent variables suggested by the combined models. Lastly, we review biomarkers suggested from the mouse and zebrafish model metabolomes, the PPCCA, and Ingenuity Pathway Analysis. We consider these biomarkers with a morphometric analysis of the zebrafish, where few significant differences …
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The role of CysLT1R in animal models of colorectal cancer
… the role of CysLT1R in different mouse models of colorectal cancer. In the mouse xenograft model of colon cancer, we were able to observe a reduced tumor growth in response to CysLT1R antagonist treatment. The inhibition of the tumor growth was accompanied with changes in proliferation …
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Natural versus synthetic alpha-tocopherol using cell and animal models
… disease and immune response. Unlike wild animals that obtain their α-T exclusively from nature, humans consume naturally-occurring α-T from plant components, as well as a synthetic form from α-T-fortified food products and supplements. These two α-T sources differ in their stereochemistry: …
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Medulloblastoma: New animal models, preclinical drug testing, and characterising immune infiltrates
… expanding the repertoire of accurate disease models, the development of novel therapies and the initiation of clinical trials, and an improvement in the understanding of the disease pathogenesis. The purpose of this thesis was to contribute to the repertoire of animal models, assist in …
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Proteomic Profiling of Animal Models of Myotonia and Motor Neuron Disease
… muscle tissue from the Wobbler mouse; an animal model of motor neuron degeneration. In contrast to myotonia the WR protein profile displayed a slow-to-fast muscle transformation. The detailed MS-based analysis of diseased skeletal muscle has shown that proteomics is highly suitable to …
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Stem Cells as a therapy for myocardial infarction in animal models
… interest within cardiology when it was shown in animal models that intramyocardial injection of bone marrow stem cells (MSCs), or the mobilization of bone marrow stem cells with spontaneous homing to myocardium, could improve cardiac function and survival after induced myocardial infarction (MI) …
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DEVELOPMENT OF IMPROVED ARTERIAL SPIN LABELING METHODS IN HUMANS AND ANIMAL MODELS
Arterial spin labeling (ASL) is an important tool in evaluating cerebral blood flow (CBF), with applications in clinical imaging for brain tumors and stroke, and as a research tool for brain injury and Alzheimers disease. Multi-TI ASL makes it possible to measure CBF and arterial transit time …
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ETHANOL INHIBITION OF DOPAMINE TRANSMISSION IN ANIMAL MODELS OF ALCOHOL ABUSE LIABILITY
Mesolimbic dopamine neurons, originating in the ventral tegmental area (VTA) and projecting to the nucleus accumbens (NAc), have been heavily implicated in the reinforcing and rewarding properties of natural and drug rewards and cues that predict these rewards. Ethanol's effects on dopaminergic …
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ANIMAL MODELS FOR BEHAVIORAL CHANGES OR HEARING LOSS UPON ACUTE VIRUS INFECTIONS
… RNA viruses are of high importance to study as models of neurological sequelae; arenaviruses and alphaviruses. Both of these viruses are important human pathogens and the cause of the long-term neurological damage, the related pathology and the mechanisms associated with sequelae have not been …
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Biodistribution of Modified Extracellular Vesicles In Normal and Tumor-Bearing Animal Models
… initiation of tumor in colorectal cancer (CRC) animal model through inducing the antitumor immune response. One of the critical aspects of using EVs as a therapy and/or a drug delivery system is to understand their biodistribution in vivo. In this thesis, we systemically injected modified EVs …
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Proteomic Profiling of Animal Models of Motor Neuron Disease and Muscular Dystrophy
… analysis of various diseased muscle groups from animal models of motor neuron disease and XQlinked muscular dystrophy is presented, in addition to motor neuron disease associated globozoospermia. This research has shown that both gel electrophoresis based and/or liquid chromatography for …
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