Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 718 for “"animal model"”.
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Electromyographic Characterization in an Animal model of Dystonia
… basal ganglia in humans. Although the Gunn rat model of kernicterus has been extensively used to characterize the auditory features, this model has not been utilized to systematically investigate the movement disorder. In the present study, spontaneously jaundiced (jj) 16 day old Gunn rat pups …
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Electrophysiological Analysis in an Animal Model of Dystonia
… physiological mechanisms of dystonia in a rodent model as a basis for developing innovative treatments for secondary dystonias. The first half of the project was focused at developing essential techniques for systematically investigating the movement disorder in these animals. For achieving this, …
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Biomechanical and physiological investigations in the IBMPFD animal model
… cells isolated from our VCPR155H/+ mouse model showed reduced ability of mitochondrial networks to fragment when exposed to oxidative stress, indicating that intact VCP is required for the successful maintenance of mitochondrial network dynamics and quality control.
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Towards a more ethical animal model in biomedical research
… mice have emerged as the standard mammalian model organism for biomedical research. When pain relief is provided during experimentation, it typically comes in the form of transient and sometimes ineffective analgesics or anesthesia. This thesis proposes an alternative to the current method of …
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EXPERIENCE-DEPENDENT STRUCTURAL PLASTICITY IN A NATURALLY BEHAVING ANIMAL MODEL
… to changing environments is critical for an animal's survival. Neurons can undergo structural changes, such as branch addition, branch retraction, or altering the number or shape of spines which change the neural connectivity in the brain. The regulation of a neuron's structure may lead to …
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Ultrastructural characterization of ultraviolet induced corneal disease : an animal model
… keratopathy and pterygium using the rabbit as an animal model. 2) Determine by means of SEM the initial effects and subsequent recovery of the epithelium after a 3-hour dose of ultraviolet B radiation. We refer to this study as "acute" response to ultraviolet B radiation. 3) To try and confirm the …
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Efficacy of boron neutron capture synovectomy in an animal model
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Nuclear Engineering, 1999.
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Proteomic Profiling of the mdx Animal Model for Duchenne Muscular Dystrophy
… affected dystrophic tissues using the mdx mouse model; from severely dystrophic diaphragm; moderately affected hind limb to naturally protected interosseus muscle were used to investigate the pathogenesis of the disease. Proteomic analysis of the muscle subtypes indicated that skeletal muscles …
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Social facilitation of polydipsia as an animal model of compulsive behavior
… which compulsive behaviors are acquired, via an animal model. Schedule-induced polydipsia (SIP) was employed as the behavior of interest because there is empirical support indicating it as an animal model of compulsive behavior. The fundamental issue was to determine if naïve rats exposed to rats …
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Selection indices for combining marker genetic data and animal model information
… including marker information directly into the Animal Model, Best Linear Unbiased Prediction system, but several problems need to be solved before their approach becomes feasible. Other selection indices were suggested but either do not use all the available information or are suitable only for …
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Drinking Behavior and Sodium Appetite in an Animal Model of Hepatic Cirrhosis
No abstract prepared.
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Spotting pain in the brain. Towards a useful animal model of pain
Current models of pain in conscious animals usually scores nocifensive responses. However, it is still unclear to what extent these responses are related to, for instance, the sensory discriminative or affective aspects of pain. This touches upon an intriguing question on how the nervous system …
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Neurobiologically-motivated treatments for post-traumatic stress disorder in an animal model
This thesis demonstrates that chronic immobilization stress administered to rats enhances fear learning and increases plasma acylated ghrelin. This effect is independent of the hypothalamus-pituitary-adrenal (HPA) axis since it was unaffected by prior bilateral adrenalectomy. Chronic exposure to a …
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Improvement in accuracy using records lacking sire information in the animal model
… computer simulated data to improve accuracy of animal model genetic evaluations by including records lacking sire identification. Methods 1 and 2 assumed genetic values of cows missing sire identity were population and management group average, respectively. Methods 3 and 4 accounted for genetic …
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Examining Hippocampal Reelin Expression and Neural Plasticity in an Animal Model of Depression
… the molecular details of this stress-induced remodeling and how it contributes to the development of depression. Currently, one candidate molecule of particular interest is reelin, an extracellular matrix protein responsible for regulating neuronal maturation and synaptic plasticity in the adult …
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Use of fluorescent micropsheres to measure coronary flow reserve in rat animal model
… is thus important to measure in experimental animal models of heart disease. A standard method to measure CBF uses tracer microspheres (O = 15 um) injected into the left ventricle that flow through coronary arteries but cannot pass through capillaries and so become trapped in heart muscle. …
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Myocardial force and intracellular Ca2+ in an animal model of hypertensive heart failure
… to decompensated end-stage heart failure in an animal model of human essential hypertension. In order to carry out this aim, left ventricular trabeculae were utilized from failing hearts of spontaneously hypertensive rats (SHR) and their normotensive Wistar-Kyoto (WKY) controls. At a …
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