Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 114 for “"animal experimentation"”.
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The ethics of animal experimentation: the Littlewood report
… defence of a laissez-faire approach to animal experimentation is ethically indefensible on grounds that non-human animals are sentient, autonomous beings who express an acute interest in their continued existence and demonstrate an aversion to the frustration of their interests; as such, …
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Animals, Science and Gender: Animal Experimentation in Britain, 1947-1965
… of the culture of science and its use of animals in experiments by the British military and in medical scientific research, and its regulation by law, during the period 1947 to 1965. The overall aim of this thesis is to demonstrate the gendered nature of scientific experimentation on …
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EMOTIONAL MODELS: UNCERTAINTY AND THE ETHICS OF ANIMAL EXPERIMENTATION IN NEUROSCIENCE
… stress disorder (PTSD) discuss the value of animal research. Since the mid-2000s, the field of animal experimentation has undergone changes as researchers published several studies addressing neuroscience’s challenges with replicating and translating animal research. Around this time, major …
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How Software Transparency Can Mitigate Conflicts Among Different Stakeholders in the Animal Experimentation Domain
The arguments of whether animals should be used in the experiments have existed for decades. Stakeholders such as animal advocates, scientists, and mediators have been calling for more transparency to tackle the conflicts. They all claim that being transparent is a way to understand each other and …
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Cyborg Butterflies, Liminal Medicine: Thyroid Hormone Treatment, 1890-1970
… treatment (THT) that centers on the bodies of animals and women between 1890 and 1970. This history contextualizes the current debate between two forms of THT, desiccated and synthetic. Drawing on the discourses present in biomedical journals, I trace how medical practitioners used the animals …
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The bureaucracy of empathy : vivisection and the question of animal pain in Britain, 1876-1912
… construction of pain in British regulation of animal experimentation. It investigates the Home Office's implementation of the Cruelty to Animals Act (1876), the first effort anywhere in the world to impose legal restrictions on vivisection, during the three decades following its enactment. The …
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Investigating the cellular toxicology of silver nanoparticles using a single-cell, mitosis-focused approach
… current need of toxicology research to replace animal testing with predictive in vitro models. Cell division-based assays would be better at predicting risk than other commonly used in vitro measurements, such as persistent cell cycle arrest or cell death. Finally, single-cell microscopic …
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The use of animals for medical experimentation: an analysis of young people's perceptions in Britain
Understanding public attitudes towards using animals for medical experimentation and the issues that cause public concern is of importance scientifically, economically and ethically. Although national opinion poll data appear to provide enough evidence to propose the hypothesis that 'the majority …
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The prospects for human germline genetic modification: scientific and bioethical considerations
… of two otherwise disparate bioscience fields - animal transgenesis and human gene therapy. Gene transfer is the route to transgenic animals, and human gene therapy depends upon gene transfer. The thesis argues that HGGM is now scientifically possible: the tools of animal genetic modification - …
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Safety standards for police body armour
… Current knife-resistance standards are based on animal experimentation and have not been examined by any other model. To understand the protective requirements of armour, it is necessary to understand the weapon threat, the assailant’s method of delivery, and the vulnerability of the target. The …
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The influence of anesthesia and nicotine on dopamine signaling in the rat dorsal striatum
<p>The striatum is highly innervated by dopamine neurons and is involved in movement control (dorsal striatum) reward learning (ventral striatum). Fast-scan cyclic voltammetry (FSCV) is a technique that uses microelectrodes (diameter ~5 μm, length ~150 μm) to monitor dopamine signaling in the …
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The Pacemaker Function of the Small Intestine
<p>New evidence is presented to clarify to some extent the significance of the gradient of rhythmicity in the small intestine of the unanesthetized dog. The gradient of rhythmicity was studied on five dogs prepared with duodenal fistulas. Rhythmic contractions were recorded from the small intestine …
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Concurrent Infections of TRYPANOSOMA EQUIPERDUM and TRICHINELLA SPIRALIS in Mice
<p>In concurrent infections of <em>Trichinella spiralis</em> and <em>Trypanosoma equiperdum</em>, the survival times vary in the early stages of the <em>Trichinella</em> infection. On Days 1 and 4, the mean survival times are significantly increased, and on Days 3 and 7 they are markedly decreased. …
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Impact of Oxytocin and Tetrahydrocannabinol on signs of fear in the rat
<p>BACKGROUND: Oxytocin (OXT) has been used as a post-treatment for post-traumatic stress disorder (PTSD). Previous research suggests that pre-treatment of intranasal OXT attenuates signs of fear in rats; however, the impact of intraperitoneal (i.p) OXT pre-treatment on signs of fear in rats is …
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Seasonal infection of invasive Brook Stickleback (Culea inconstans) by the nematode Contracaecum multipapillatum at Turnbull National Wildlife Refuge, Washington
<p>The brook stickleback (Culaea inconstans) was first identified in Washington state in 1999 and has since established high population densities at Turnbull National Wildlife Refuge (TNWR). Fish parasitized by Contracaecum multipapillatum, a nematode known to infect zooplankton, piscivorous birds, …
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Identifying notch-regulated genes using a specific notch signaling inhibitor
<p>Bone remodeling is a dynamic process that requires a balance between bone resorption by osteoclasts and bone formation by osteoblasts to maintain skeletal integrity. Disruptions to this equilibrium can lead to pathological conditions such as osteoporosis. Osteoclasts originate from macrophages, …
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Concurrent Infection of TRYPANOSOMA MUSCULI Kendell, 1906, and SCHISTOSOMA MANSONI Sambon, 1907 in Mice
<p>The possible effects of ablastin on <em>Schistosoma mansoni</em> were investigated by (1) establishing a concurrent infection of <em>Trypanosoma musculi</em> and <em>Schistosoma mansoni</em> in mice, and (2) by obtaining <em>Trypanosoma lewisi</em> immune rat serum (ablastin) and injecting it …
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Walleye (Sander vitreus) do not exhibit an aggregative predatory response to larval White Sturgeon (Acipenser transmontanus) in the Upper Columbia River in Lake Roosevelt, Washington
<p>Seasonal prey abundance can drive predatory fishes to aggregate in areas of high prey density. This project aimed to determine whether Walleye (Sander vitreus) exhibit an aggregative predation response to larval White Sturgeon (Acipenser transmontanus) drifts in the Lake Roosevelt system which …
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Effect of Sensory Additives on Sow Lactation Performance, Subsequent Reproductive Performance, and Nursey Pig Performance
<p>Maximizing nutrient intake during lactation is vital to sow performance as well as litter performance. The aim of these studies was to evaluate the impact of a sensory additive on sow lactation performance and nursery pig performance. Five groups of sows were farrowed, three during winter …
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Evaluation of the Effect of a Lippia organoides Essential Oil Extract on Clostridium perfringens Proliferation In Vitro and Necrotic Enteritis in Broiler Chickens
<p>The purpose of the present research was to assess the effects of essential oils derived from the plant Lippia organoides on performance parameters, intestinal integrity, and necrotic enteritis (NE) in broiler chickens. To do this, a previously established challenge model for NE was utilized …
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