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Showing 1 to 20 of 54 for “"anilines"”.
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Self-Assembly of Tetra-Anilines into Metal-Organic Architectures
… it will be demonstrated that rectangular tetra-anilines, even those with relatively high aspect ratios (i.e. they show significant deviation from a square), can assemble into Zn₈L₆ pseudo-cubes. There are myriad possible diastereomeric configurations that could be adopted; however, remarkable …
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The palladium-catalyzed synthesis of organic amines
… active catalyst system for the coupling of anilines with aryl bromides. The bisphosphine is easily prepared in large quantity and at low cost by a known procedure. The catalyst system is effective in coupling reactions involving a variety of substrates, including electron-poor anilines or …
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Pd-Ag Catalyzed Aza-Piancatelli Reaction: From Synthesis to Mechanistic Investigations
… a broad substrate scope across ortho-substituted anilines but shows limited reactivity with para-substituted anilines at room temperature. Oxygen nucleophiles were found to be unsuccessful. At elevated temperature of 80°C, para-substituted anilines showed improved reactivity with silver catalyst …
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Carbon Nitride as a Heterogeneous Photocatalyst for Organic Transformations
… nitride has been explored for the preparation of anilines using a dual photocatalytic system. Various anilines are prepared by the cross-coupling of aryl halides with sodium azide in mild conditions. Mechanistic studies are performed to deduce the formation of anilines instead of aryl azides.
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Recent advances in copper- and palladium-catalyzed carbon-heteroatom and carbon-carbon bond-formation
… oxindoles, 2-, 3- and 4-hydroxypyridines, anilines, and aliphatic, benzylic, allylic and propargylic alcohols. In many cases, catalyst optimization and ligand structure are discussed and evaluated. Where applicable, the palladiumand copper-based catalyst systems are contrasted to …
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Myers-Inspired Selenium-Mediated Isomerization: An Efficient Generation of Contra-Thermodynamic Allenes and Alkenes with the Potential for Reductive Deamination of Primary Amines and Metal-Free Hydrogenation of Dienes
… such as the reduction of primary amines such as anilines, and diamines to monoenes.
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Regioselective, Nucleophilic Activation of C-F Bonds in o-Fluoroanilines
Reactions of fluorinated anilines with stoichiometric Ti(NMe2)4 in mesitylene (typically for 23 h at 120 °C) afforded moderate to high yields of the corresponding N,N-dimethyl-o-phenylenediamine derivatives resulting from defluoroamination of a fluorine atom ortho to the NH2 of the starting …
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Exploiting activated esters in novel chemoselective amide formation reactions
… those involving chemoselective reactions between anilines and N-substituted anilines. Additionally, the chemoselective agent was also used in preparation of pharmaceutically important compounds. To round off the thesis the application of one of the target compounds-benzanilide-was used to develop …
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The Exploration of a Strategy for Regioselective Arene Amination Utilising Non-Covalent Interactions
… of arene C-N bonds for the preparation of anilines is one of the most used reactions in industry and academia. Numerous methods which utilise reactive N-centred radicals for the synthesis of anilines from arenes have recently been developed. However, regiochemical control is a major …
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Trichloroacetimidates as Alkylating Reagents in C-N Bond Formation and Synthesis of Aminosteroid and Quinoline Inhibitors of Src Homology 2 Domain-Containing Inositol Phosphatase (SHIP)
… alkylating reagents for the monosubstitution of anilines using the Brønsted acid catalyst (±)-camphorsulfonic acid. The reaction is especially efficient for electron deficient anilines while electron rich anilines provided lower yields due to competing Friedel-Crafts reactions. A one-pot …
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Quantifying Cooperativity in Non-Covalent Networks
… H-bond to a pyridine was used to study anilines and sulfonamides. The value of κ for the anilines when H-bonding intermolecularly to a phosphine oxide was found to be -0.10 as the two H-bonds are negatively cooperative, either due to through-space repulsion or changing polarity of the NH …
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Studies on extensions of tert-amino effect: Ring-fusion to bridged biaryls and steroids
… isomerization of ortho-substituted tertiary anilines to benzo-fused heterocyclic systems. In type 2 reactions, an ortho-vinyl tert-aniline gives a tetrahydroquinoline via C-C bond formation between the beta-vinyl carbon and the alfa-methylene carbon of the amino group; the reaction could be …
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Computational modeling of organic structure, spectra, and reactivity
… and kinetic isotope effects of substituted anilines. The use of proton nucleomers to calculate linear free energy relationships to reduce both experimental and computational time is examined. A significant portion of this thesis is dedicated to the use of calculated nuclear magnetic …
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A hydrogen bonding ortho-directing effect for the iridium catalyzed borylation of NH(t-BOC) aromatics
… and a ligand screen. The obtained borylated anilines are useful precursors to 3,4-dihydroquinolin-2-one heterocycles.
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Chemical Methods for Cobalt-Catalysed C(sp3)–H Activation and Iodonium Salt-Mediated Peptide Functionalisation
… room temperature synthesis of substituted anilines. A diverse range of aromatic groups, including aryl halides and heteroaromatic functionality, were successfully transferred by this strategy. Excellent selectivity for the hydroxylamine group was observed in the presence of unprotected …
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Expanding the substrate scope in palladium-catalyzed C-N and C-C bond-forming reactions
… aryl nonaflates resulted in excellent yields of anilines; even 2-carboxymethyl aryl nonaflate is effectively coupled with a primary alkyl amine. Moderate yields were obtained when coupling halo-aryl nonaflates with a variety of amines, where in most cases the aryl nonaflate reacted in preference …
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Synthesis of novel 5,6-disubstituted derivatives of uracil as potential drugs
… that was condensed with phenols or anilines to give the respective 6-phenoxyuracils and 6- phenylaminouracils. These intermediates were then modified in position 5 to give the final products. For this very challenging last step, various alkylating and acylating agents were used, e.g. …
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Annulation strategies for the synthesis of azulenes and polycyclic nitrogen heterocycles
… benzannulation reactions, highly-substituted anilines, then participate in ring closing metathesis reactions to form various nitrogen heterocycles. In particular dihydroquinolines, hydrobenzoazepines, and hydrobenzoazocines were synthesized via this tandem ynamide benzannulation ring closing …
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Mechanisms of toxicity and carcinogenicity of three alkylanilines
Alkyl-substituted anilines have been implicated as important etiological agents in human carcinogenesis. Specifically, 2,6-dimethylaniline (2,6-DMA), 3,5-dimethylaniline (3,5-DMA), and 3-ethylaniline (3EA) have been associated with an increased risk of human bladder cancer, independent of cigarette …
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Fundamental studies on 2,4,6-trichlorophenyl sulfonate esters
… simple aliphatic amines and more challenging anilines have been found. The differing reactivity’s of the TCP and PFP sulfonate esters have been exploited in selective sulfonamide formation. The greater stability of TCP sulfonate in comparison to PFP sulfonate also means that a broader range of …
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