Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"angiotensin type 1 receptor"”.
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Investigating the role of the Renin Angiotensin System in cancer
… as possible anti-cancer agents. The renin-angiotensin system (RAS) regulates blood pressure and cardiovascular homeostasis through Angiotensin Converting Enzyme-1 (ACE-1) and its homolog ACE-2. RAS has also been implicated in the progression of various cancers due to the increased action of …
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A ROLE FOR ANGIOTENSIN-(1-7) TO ATTENUATE ADVANCED GLYCATION END PRODUCT -INDUCED MYOFIBROBLAST TRANSITION IN THE NRK-52E RENAL PROXIMAL TUBULE CELL LINE
… evidence for a role of intracellular renin-angiotensin system (RAS) in cell signaling, function and cardiovascular pathologies. Diabetic nephropathy is a very common complication in which tubulointerstitial fibrosis may arise from epithelial to mesenchymal transition (EMT) of the proximal …
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Angiotensin II-mediated Regulation of the Human Angiotensin II Type 1 Receptor Gene
The physiological responses of angiotensin II (Ang II) are mediated across the cell membrane through the angiotensin II type 1 receptor (AT1R), a heptahelical membrane protein coupled to trimeric G-proteins on the cytosolic side. AT1R on binding its ligand, Ang II, leads to downregulation of …
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Mas Receptor Agonism for the Treatment of Amyotrophic Lateral Sclerosis (ALS)
… target of interest is by modulating the renin-angiotensin system (RAS), mediated by the activation of the mas receptor. The RAS consists of a family of G-Protein Coupled Receptors (GPCR) that serve a dual role. The pathological arm includes angiotensin converting enzyme (ACE), angiotensin-II, …