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Showing 1 to 20 of 321 for “"angiotensin"”.
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Angiotensin II-mediated Regulation of the Human Angiotensin II Type 1 Receptor Gene
The physiological responses of angiotensin II (Ang II) are mediated across the cell membrane through the angiotensin II type 1 receptor (AT1R), a heptahelical membrane protein coupled to trimeric G-proteins on the cytosolic side. AT1R on binding its ligand, Ang II, leads to downregulation of …
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Cellular mechanisms of angiotensin release
In this study we examined angiotensin (ANG) release from primary cultured rat brain cells in response to ion stimulation and ligands that stimulate or inhibit second messenger systems in an attempt to understand how the release of ANG is regulated.
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The Role of Angiotensin-(1-7) in the Modulation of Angiotensin II-Dependent Cardiac Remodeling
… of both hemodynamic and humoral factors, such as angiotensin II (Ang II). Angiotensin-(1-7) [Ang-(1-7)] is an endogenous heptapeptide of the renin-angiotensin system with anti-proliferative properties which oppose the actions of Ang II. The purpose of this study was to determine whether Ang-(1-7) …
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Angiotensin II signalling in sensory neurons
Angiotensin II (Ang II) is a peptide associated with the regulation of blood pressure, though the elevated presence of Ang II in the inflamed bowel – and other inflamed tissues – and the presence of receptors for Ang II on sensory neurons may point to additional roles in nociception in inflammatory …
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STUDIES ON ANGIOTENSIN-(1-7) AND MITOCHONDRIA: THE ROLE OF AN INTRACELLULAR RENIN-ANGIOTENSIN SYSTEM WITHIN THE KIDNEY
… classic circulating hormonal system - the renin-angiotensin System (RAS), and specifically, the ACE-Ang II-AT1 receptor axis. We have focused strategically on investigating novel intracellular pathways by which Ang-(1-7) is generated and degraded since this alternative pathway within the kidney …
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EFFECT OF ANGIOTENSIN PEPTIDES ON VASCULAR REMODELING
… direct cost estimated at $286 billion each year. Angiotensin II (Ang II), one of the biologically active peptides of the renin-angiotensin system, elicits many maladaptive effects on the cardiovascular system. Over the past two decades, numerous studies demonstrated that the other biologically …
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Combination Treatment of Angiotensin-II Receptor Blocker and Angiotensin-Converting-Enzyme Inhibitor in Non-Diabetic Renal Disease on Effect of Reducing Proteinuria
BACKGROUND: The fact that angiotensin-converting enzyme inhibitors(ACEI) and angiotensin receptor blockers(ARB) antagonize the renin-angiotensin system at different levels suggests that these agents, already confirmed by clinical benefit in retarding the progression of chronic renal disease, may …
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RADIATION-INDUCED BRAIN INJURY AND THE RENIN-ANGIOTENSIN SYSTEM
… has been pharmacologic suppression of the reninangiotensin system (RAS). The brain has its own intrinsic RAS which has effects beyond cardiovascular and fluid homeostasis including learning, cognition and memory. Although the pathogenesis of radiation injury remains unclear, we hypothesize that …
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Inhibitoren des Angiotensin Converting Enzyme (ACE) in hypoallergenen Säuglingsnahrungen
Als Schlüsselenzym im Renin-Angiotensin System übernimmt das Angiotensin Converting Enzyme (ACE) eine wichtige Rolle bei der Blutdruckregulierung. ACE spaltet das biologisch inaktive Angiotensin I zum vasokonstriktorisch wirksamen Angiotensin II, was zu einem Anstieg des Blutdruckes führt. Tier- …
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Characterisation of the ectodomain shedding of angiotensin-converting enzyme
Bibliography: leaves 240-266.
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Protein-protein interactions of human somatic angiotensin-converting enzyme
… were engineered into the linker region of ACE [Angiotensin-converting enzyme] in an attempt to limit inter-domain movement, thereby producing a candidate for crystallisation and to determine the effect of these bridges on inter-domain movement.
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The Role of Angiotensin II in Skeletal Muscle Metabolism
… linked. As such, the major player in the renin, angiotensin system, angiotensin II, has recently been investigated for its effects on metabolism and diabetes. Since skeletal muscle is one of the most metabolically active tissues, this study investigates the effects of angiotensin II specifically …
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Cellular pathways of angiotensin II signalling in the hypertrophic myocardium
… of these studies is the cellular action of angiotensin II (ATII) on the hypertrophic myocardium. The significance of this work is both biological and clinical: biological, because ATII has direct effects on the normal heart muscle and the intracellular signalling pathways activated by ATII …
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Vascular Endothelin and Angiotensin Receptors Regulation in Inflammatory Arterial Disorders
… with the expression of vascular endothelin and angiotensin receptors. The receptor changes were studied in subcutaneous resistance arteries in patients with different degrees of ischemic heart disease (IHD). In addition, patients with giant cell arteritis (GCA) were also investigated because of …
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Studies of the renin angiotensin system in the human vasculature
The work presented in this thesis concentrates on the local generation of AII. Preliminary experiments using wire myography were performed in human resistance arteries from normal subjects, obtained by subcutaneous gluteal at biopsy. In these vessels, AI stimulated a contractile repose that was …
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Charakterisierung des Angiotensin II AT1-Rezeptors in humanen differenzierten Podozyten
… von allen wesentlichen Bestandteilen des Renin-Angiotensin-Systems in humanen differenzierten Podozyten gezeigt, sondern auch die Funktionalität dieses RAS nachgewiesen. Es wurden hierzu besonders die Eigenschaften des AT1-Rezeptors untersucht. Mittels Messung der [Ca2+]i wurde die …
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Neuronale Effekte von lokal gebildetem Angiotensin II im menschlichen Vorhof
… Herzvorhofpräparaten eine lokale Konversion von Angiotensin I in Angiotensin II sowohl durch ACE, als auch durch alternative Mechanismen stattfindet. Die präsynaptische, steigernde Wirkung von Angiotensin II auf die stimulationsinduzierte Freisetzung von Noradrenalin aus den sympathischen Fasern …
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The Renin-Angiotensin System in The Freshwater Turtle Pseudemys Scripta
… to verify the existence of an endogenous renin-angiotensin system in this species. It was shown that Pseudemys scripta possess renal renin, renin substrate in the plasma, angiotensin converting enzyme activity, and vascular receptors specific for angiotensin. Kinetic analyses were performed on …
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Engineering the angiotensin II type 1 receptor for structural studies
… objective of this project was to engineer the angiotensin II type 1 receptor (AT1R), a human GPCR, to make it suitable for structural studies. It was determined that detergentsolubilised AT1R was thermostable with antagonist bound with an apparent Tm of ~45°C, which was sufficiently stable for …
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Rat angiotensin-converting enzyme : tissue specific expression during pharmacological inhibition
The renin-angiotensin system plays a central role in the maintenance of blood pressure. Angiotensin II, the main effector of this system, results from the action of angiotensin-converting enzyme (ACE) on angiotensin I. Angiotensin II, maintains vasomotor tone via its vasoconstrictor action, and …
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