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Showing 1 to 16 of 16 for “"angiopoietin-2"”.
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Einfluss von Angiopoietin-1 und Angiopoietin-2 auf die Angiogenese im Ratten-Gliommodell
Angiopoietine spielen eine wichtige Rolle in der Angiogenese. Sie beeinflussen die Neubildung und das Wachstum von Blutgefäßen und sind an der Reifung von Gefäßen beteiligt. Außerdem sind Angiopoietine für die Erhaltung der Gefäßstabilität unverzichtbar. <br>Die Bedeutung der Angiopoietine in der …
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The Role of Angiopoietin-2 in Signaling Through the Endothelial Receptor Tyrosine Kinase Tie1
… and the effects of their associations with the Angiopoietins have not been elucidated. Studies in this thesis investigated the effects of Ang2 on Tie1 activation, signaling, and cellular responses within the context of both native and immortalized endothelial cells. Additionally, we investigated …
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Angiopoietin-2 and platelet-derived growth-BB factor cooperatively affect peripheral blood monocyte fibrinolysis
Includes bibliographical references.
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Arteriovenöse Differenzierung humaner Endothelzellen: Einfluss von Wachstumsfaktoren, Hypoxie und Biomechanik
… der vorliegenden Arbeit analysiert wurden, sind Angiopoietin-2 und CD44s. Trotz der genetisch definierten Unterschiede ließ der Vergleich physiologisch relevanter Funktionen, wie Proliferation oder die Interaktion mit monozytären Zellen keinen vom endothelialen Zelltyp abhängigen Unterschied …
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The Effect of Ischemia and High-Fat Diet on Pericyte Fate
… transcript levels of destabilizing factor Angiopoietin 2 mRNA. Overall, this study can be the first step in understanding the participation of pericytes in ischemic muscle recovery.
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Dynamics of vascular normalization during anti-angiogenic therapy : implications for combination therapy
… time PCR and Western blot analyses, changes in angiopoietin-2 level during DC101 treatment are identified. To test if similar effects happen in clinical setting, we obtained tumor biopsy samples from rectal adenocarcinoma patients treated with bevacizumab, an anti-VEGF monoclonal antibody.
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Role of transcription factor Runx1 in uterine stromal cell differentiation and maternal-fetal interaction during mouse pregnancy
… several angiogenic factors, such as VEGF-A and angiopoietin-2. Furthermore, immunohistochemical analysis of smooth muscle actin and cytokeratin in the uterine sections of the mutant mice revealed a lack of maternal spiral artery modification and restricted trophoblast invasion. Collectively, …
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The Role of Arginine Vasopressin Receptor 2 in Microvascular Hyperpermeability During Severe Sepsis and Septic Shock
… 4 (PLCβ-4) and the potent permeability factor angiopoietin-2. In conclusion, the results of the present work show that endothelial V2R activation increases vascular permeability during sepsis and perhaps its closer modulation could improve the outcome of these critically ill patients. The …
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Role of The Ang-Tie2 Pathway In The Invasive Recurrence of Gbm Following Anti-Vegf Therapy
… Furthermore, we have shown that expression of angiopoietin 2 (Ang2), a Tie2 ligand, is dramatically increased in the periphery of the tumor after aflibercept treatment. Interestingly, our data provides evidence that Ang2 is chemoattractant to TEMs, both <em>in vitro</em> and <em>in vivo …
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AMBIENT OXYGEN AVAILABILITY MODULATES EXPRESSION OF VASCULAR ANGIOGENIC FACTORS AND CAPILLARY REMODELING (ANGIOPLASTICITY) IN THE MOUSE BRAIN
… expressions of cyclooxygenase-2 (COX-2) and angiopoietin-2 (Ang-2) were elevated during hypoxia as well as re-oxygenation. Significantly increased capillary density at the end of the 3rd week of hypoxia regressed back toward normoxic baseline during re-oxygenation.In the second part of this …
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Organ Specific Vascular Response to Fibrosis Affects Breast Cancer Metastatic Organotropism
… circulating levels of the pro-angiogenic factor Angiopoietin 2 that increased vascular permeability of the lungs, but not the kidneys. In fact, while fibrotic lungs showed decreased expression of endothelial tight gap junction protein Claudin-5, the fibrotic kidneys had an elevated expression of …
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Improving outcomes for obese children with Acute Lymphoblastic Leukaemia (ALL): a clinical collaboration to understand the influence of obesity on treatment success.
… We have shown that leptin, IL-8, serpin A12 and angiopoietin-2 have a protective effect when incubated with the Molt4 ALL cell line and that resistin does not offer this protection.Further experiments with leptin confirmed the activation of the PI3K/Akt pathway which is a shared pathway with the …
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Eph-mediated restriction of cerebrovascular arteriogenesis
… remodeling via attenuation of the Tie2/Angiopoietin-2 signaling pathway. The work presented in this dissertation demonstrate that EphA4 can be targeted therapeutically to increase pial collateral remodeling to alleviate neurological deficits after ischemic stroke.
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Tumor Angiogenesis is all Tied up in Tie2-Expressing Macrophages
… increased migration of monocytes towards Angiopoietin-2 (Ang-2) and resulted in greater branch formation in an in vitro endothelial tube formation assay. A neutralizing antibody against the M-CSF receptor abrogated this activity as did knockdown of the Tie2 receptor through the use of a …
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Development and validation of a biomarker-based model to predict persistent hypoxemic respiratory failure among mechanically ventilated adults
… (interleukin-6 [IL-6], interleukin-8 [IL-8], angiopoietin-2 [Ang-2], soluble tumor necrosis factor receptor 1 [sTNFR-1], measured in a subset) could improve model performance. I calculated area under the curve (AUC) for model performance. Results. Approximately half of patients in the …