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Showing 1 to 20 of 31 for “"angiopoietin"”.
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Einfluss von Angiopoietin-1 und Angiopoietin-2 auf die Angiogenese im Ratten-Gliommodell
Angiopoietine spielen eine wichtige Rolle in der Angiogenese. Sie beeinflussen die Neubildung und das Wachstum von Blutgefäßen und sind an der Reifung von Gefäßen beteiligt. Außerdem sind Angiopoietine für die Erhaltung der Gefäßstabilität unverzichtbar. <br>Die Bedeutung der Angiopoietine in der …
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The Role of Angiopoietin-2 in Signaling Through the Endothelial Receptor Tyrosine Kinase Tie1
… and the effects of their associations with the Angiopoietins have not been elucidated. Studies in this thesis investigated the effects of Ang2 on Tie1 activation, signaling, and cellular responses within the context of both native and immortalized endothelial cells. Additionally, we investigated …
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Angiopoietin-2 and platelet-derived growth-BB factor cooperatively affect peripheral blood monocyte fibrinolysis
Includes bibliographical references.
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Das Adipokin fasting-induced adipose factor/angiopoietin-like protein 4 in Abhängigkeit von der Nierenfunktion
… Jahr 2000 wurde fasting-induced adipose factor/angiopoietin-like protein 4 (FIAF/Angptl4) als ein neuartiges Adipokin eingeführt, welches eine wichtige Rolle im Lipid- und Glukosestoffwechsel ausübt. In der vorliegenden Studie wurde erstmals der Zusammenhang zwischen FIAF/Angptl4-Serumspiegeln …
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Effect of Acute Administration of Angiopoietin-1 In Experimental Traumatic Spinal Cord Injury: Magnetic Resonance Imaging and Neurobehavioral Studies
… recovery in SCI. In these studies, angiopoietin-1 (Ang1), an agent known to reduce vascular permeability, was hypothesized to attenuate the severity of secondary injuries of SCI. Using longitudinal magnetic resonance imaging (MRI) studies (dynamic contrast-enhanced [DCE]-MRI for …
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Integrin-independent activation of Tie2 using the de novo designed protein H8mb
The Angiopoietin–Tie2 signaling axis is a central regulator of vascular stability, yetefforts to harness it therapeutically have been limited by the poor developability and receptor promiscuity of Angiopoietin-1 (Ang1), which binds both Tie2 and α5β1 integrin. Here we report the de novo design of a …
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Hemmung retinaler Gefäßneubildung durch lösliche Rezeptoren angiogener Mediatoren bei der Maus
… Faktoren, wie in diesem Falle VEGF und Angiopoietin, reduziert werden. Ziel ist, alternative Therapiekonzepte für hypoxieinduzierte proliferative Retinopathie bei Diabetikern, Frügeborenen und Patienten mit Gefäßverschlüssen zu entwickeln. <br>Methode der Untersucher: Sieben Tage alte …
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Arteriovenöse Differenzierung humaner Endothelzellen: Einfluss von Wachstumsfaktoren, Hypoxie und Biomechanik
… der vorliegenden Arbeit analysiert wurden, sind Angiopoietin-2 und CD44s. Trotz der genetisch definierten Unterschiede ließ der Vergleich physiologisch relevanter Funktionen, wie Proliferation oder die Interaktion mit monozytären Zellen keinen vom endothelialen Zelltyp abhängigen Unterschied …
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The Effect of Ischemia and High-Fat Diet on Pericyte Fate
… transcript levels of destabilizing factor Angiopoietin 2 mRNA. Overall, this study can be the first step in understanding the participation of pericytes in ischemic muscle recovery.
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Molekulární mechanismy vývoje koronárních cév
… main factors overviewed are VEGF, Notch, PDGF, Angiopoietin and others. Factors function and signalization is reviewed in details....
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Investigating the link between post-tuberculosis lung disease (PTLD) and circulatory biomarkers in a South African cohort
… stress biomarkers, including ADMA, VCAM-1, VEGF, angiopoietin-1, TBARS, NT-pro-BNP, and cardiac troponin-I, in patients stratified by the number of previous TB episodes and the time since the last treatment. VEGF and angiopoietin-1 were significantly elevated (up to 6500-fold above normal), with …
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Dynamics of vascular normalization during anti-angiogenic therapy : implications for combination therapy
… time PCR and Western blot analyses, changes in angiopoietin-2 level during DC101 treatment are identified. To test if similar effects happen in clinical setting, we obtained tumor biopsy samples from rectal adenocarcinoma patients treated with bevacizumab, an anti-VEGF monoclonal antibody.
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Novel Immune-Regulatory Mechanisms in a Mouse Model of Traumatic Brain Injury
… also showed that EphA4 interacts with the Tie2/Angiopoietin signaling axis to regulate macrophage phenotype on the M1/2 continuum. Overall, our work demonstrated a novel role for EphA4, mediated by Tie2, as a pro-inflammatory regulator of the peripheral-derived immune cell response to TBI.
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Role of transcription factor Runx1 in uterine stromal cell differentiation and maternal-fetal interaction during mouse pregnancy
… several angiogenic factors, such as VEGF-A and angiopoietin-2. Furthermore, immunohistochemical analysis of smooth muscle actin and cytokeratin in the uterine sections of the mutant mice revealed a lack of maternal spiral artery modification and restricted trophoblast invasion. Collectively, …
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Insulin-Like Growth Factor-Binding Protein 2 Supports Hematopoietic Stem Cell Expansion: From In Vitro to In Vivo
… ex vivo are needed. We previously showed that angiopoietin-like proteins (Angptls), a group of growth factors isolated from a fetal liver HSC supportive cell population, improved ex vivo expansion of HSCs. Here we demonstrate that insulin-like growth factor binding protein 2 (IGFBP2), secreted …
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The Role of Arginine Vasopressin Receptor 2 in Microvascular Hyperpermeability During Severe Sepsis and Septic Shock
… 4 (PLCβ-4) and the potent permeability factor angiopoietin-2. In conclusion, the results of the present work show that endothelial V2R activation increases vascular permeability during sepsis and perhaps its closer modulation could improve the outcome of these critically ill patients. The …
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Therapeutic Targeting of Arteriogenesis Following Ischemic Stroke
… of the Tie2 axis using Vasculotide, an angiopoietin-1 memetic peptide, replicates these findings. Administration of 3ug/kg Vasculotide to wildtype mice immediately after permanent middle cerebral artery occlusion leads to significantly larger pial collateral diameters, correlating with …
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Identification and Characterization of Potential Modulators of TEK/TIE-2 Signaling
… in mouse endothelial cells using its ligand, Angiopoietin-1, increased 4933402E13Rik mRNA levels. Additionally, 4933402E13Rik expression was found to be modulated through epigenetics especially by histone deacetylation. Mouse endothelial cells treated with Trichostatin A, a potent inhibitor of …
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Role of The Ang-Tie2 Pathway In The Invasive Recurrence of Gbm Following Anti-Vegf Therapy
… Furthermore, we have shown that expression of angiopoietin 2 (Ang2), a Tie2 ligand, is dramatically increased in the periphery of the tumor after aflibercept treatment. Interestingly, our data provides evidence that Ang2 is chemoattractant to TEMs, both <em>in vitro</em> and <em>in vivo …
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