Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 661 for “"angiogenesis"”.
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Glucocorticoids and angiogenesis
Angiogenesis is the creation of new blood vessels from the existing vasculature that occurs through a complex series of interactions and is tightly regulated. Glucocorticoids are acknowledged to inhibit angiogenesis at high concentrations but whether endogenous glucocorticoid concentrations are …
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Purinergic angiogenesis : an investigation of the role of extracellular nucleotide mediated signaling in angiogenesis
Angiogenesis refers to the growth and maturation of new vessels from pre-existing differentiated blood vessels. Co-ordination of angiogenic responses is crucial for a wide range of physiological and pathological processes. In particular, angiogenesis is hypothesized to facilitate tumour growth and …
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NMR imaging of tumor angiogenesis
… the proliferation of new blood vessels, i.e. angiogenesis. Considerable evidence now exists which demonstrates that these tumor vessels are associated with a distinct range of morphological and physiological properties which are not present in normal tissue vasculature. Several studies now …
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Role of KATP channels in angiogenesis
… targetable molecular mechanisms in the field of angiogenesis, since therapeutic modulation of angiogenesis can critically alter the progression of a number of diseases. Stimulation of angiogenesis is desirable in situations characterized by tissue-damaging ischemia where blood supply is severely …
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Paxillin-dependent control of tumor angiogenesis
Angiogenesis- the growth of new capillaries from existing vessels- is required for tumor growth; however, tumor vessels exhibit abnormal structure and function, which impairs the targeted delivery of anti-cancer agents. While directional migration of capillary endothelial cells is critical for …
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Does Epigenetic Silencing Affect Skeletal Muscle Angiogenesis?
… from different stressors such as exercise. Angiogenesis is the formation of new capillaries from existing vessels; allowing for better blood flow to the working skeletal muscles. Epigenetic modifications support changes in gene expression to allow for skeletal muscle adaptations. How histone …
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Role of ANLN in post ischaemic angiogenesis
Angiogenesis is a key physiological process by which new blood vessels are dynamically formed in Endothelial cell (EC) driven processes. The identification of new potential genes of interest in ECs can help to further understand the underlying mechanisms of angiogenesis and help develop new …
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Beta 3 integrins : negative regulators of angiogenesis
… inhibition by tumstatin also occurs in in vivo angiogenesis assayed using a Matrigel plug insert. Similarly to in vitro assays, tumstatin failed to inhibit angiogenesis in beta 3 integrin-deficient animals. These results suggest that avf33 integrin is necessary but not sufficient for the …
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Smooth muscle titin in embryo implantation and angiogenesis
Das Muskelprotein Titin ist mit einem Molekulargewicht von bis zu 3700 kDa das größte bekannte Polypeptid. Es ist nach Aktin und Myosin das dritthäufigste Protein im quergestreiften Muskel. Titin integriert in die Z-Scheibe und die M-Bande und überspannt damit das halbe Sarkomer. Es formt ein …
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Absolute Quantitation for MR Molecular Imaging of Angiogenesis
<p>Medical imaging is undergoing a transition from an art that is used to make static images of human physiology into a scientific tool that employs advanced techniques to measure clinically relevant data. Recently, the role of magnetic resonance imaging in cardiovascular and oncological research …
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A study of Notch signalling in developmental angiogenesis
Blood vessel patterning during angiogenesis is a guided process. Endothelial tip cells located at the end of vascular sprouts are important for vessel guidance. One of the aims of my studies is to determine how endothelial tip cell formation is regulated. Previous studies have shown that the Notch …
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Mechanical Regulation of Angiogenesis in a Biomimetic Model
… and pathological processes including angiogenesis, branching morphogenesis, and cancer progression. Dynamic regulation of cell-cell adhesions, transmission of long-range contractile forces across cells, and remodeling of the extracellular matrix (ECM) are all required for successful …
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Angiogenesis and Myogenesis in a Chronic Ischemic Heart.
<p>Miniswine underwent procedures to evaluate treating chronic ischemia with the implantation of autologous satellite cells and laser transmyocardial revascularization (TMR). The objective was to combine two therapies to restore cardiac function. This experiment involved three surgical procedures: …
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Defining the Role of PIM1 in Tumor Angiogenesis
… that heightened PIM1 expression promotes tumor angiogenesis via direct phosphorylation of HIF-1. Using orthotopic and xenograft models of prostate and colon cancer, we demonstrated that co-inhibition of PIM and VEGF produces synergistic anti-tumor effects. Finally, we have linked PIM1 expression …
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DIABETES MELLITUS AND THE DYSREGULATION OF ANGIOGENESIS IN TUBERCULOSIS
… severe disease and poorer treatment outcomes. Angiogenesis plays a key role in TB immunopathology by supporting mycobacterial survival within granulomas, whereas DM-associated oxidative stress impairs normal angiogenic processes. I hypothesized that disrupted angiogenic regulation underlies the …
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Role of ephrinB2 and EphB4 in mouse retinal angiogenesis
… and evaluated. <br>Concerning pathological angiogenesis, a single intravitreal injection of dimeric ephrinB2 or EphB4 increased the retinal angioproliferative changes significantly compared to the control eyes. No evident effects on physiological angiogenesis were observed. The PCR …
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Angiogenesis in human parathyroid disease and chronic allograft nephropathy
Angiogenesis in parathyroid disease and association with VEGF
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Cell Wall Lipids Promoting Host Angiogenesis During Mycobacterial Infection
… as an important bacterial determinant of host angiogenesis. We found that PcaA-modified trehalose dimycolate, an abundant glycolipid in the mycobacterial cell wall, drives activation of host VEGF signaling and subsequent granuloma vascularization. To facilitate our continuing investigation of …
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Bone growth following demineralized bone matrix implantation requires angiogenesis
Angiogenesis is required for endochondral ossification during development and fracture healing; however the exact mechanisms and temporal relationship between the two processes remains unclear. In this study, we utilize an in vivo model of endochondral ossification in mice by implanting …
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